G1 to S cell cycle control (Canis familiaris)

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1G1 PhaseE2fuCheckpointorigin recognition complexCyclin Dsphosphorylation of proteinsinvolved in G1/S transitionDNA polymerasesinactivebpCell cycle DNA replication genesG2 Phase-M phasepuTTTCC/GCGCpG1/S transition PhasepuRbpG1 CyclinDependant CyclasesCyclin Esdp1bepcakG1/S transition CyclinDependent KinasesDNA replicationeDegradationG1/S Cell CycleORC5TFDP1E2fRB1CCNA1LOC100855690CCNG2ATMRPA3CCND1CDK7POLE2CDKN1CLOC100855664ORC3CREB3L1CdkCDC2AATF6BORC2ORC4LOC100855704CCNE1CDKN2BMCM3E2F4CDKN1ACDKN2ARBL1CREB3L3CdkTP53TP53MCM2CCNE1TFDP1CDC45RB1CyclinDCREB1PRIM1CDK4CDKMNAT1CDKN2CCyclinDCDKCCNHPOLA2E2fMCM7TFDP2E2F1E2F3LOC100855917WEE1CDK7MCM6CCNE2CDK6CDC25AMCM4LOC100856421RB1CCND3PRIM2CCND2CREB3L4E2F5CDKN2DE2F6PCNALOC100856079MCM5CDK4CCNB1CDKN1BPOLECDK6MYT1MDM2LOC100855728CREB3ORC6CCNE1MYC


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP45(r45301) with a 86% conversion rate.

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Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95748view13:54, 19 January 2018MkutmonHomology conversion update
68574view23:00, 5 July 2013MaintBotUpdated to 2013 gpml schema
67266view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
48155view18:50, 9 May 2012MaintBotUpdating from human to fix xrefs
40732view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35826view22:00, 17 February 2010KhanspersModified description
34010view18:41, 9 December 2009MaintBotAutomatic update of empty xrefs
32271view13:05, 15 August 2009MaintBotFixed text labels
31805view12:19, 14 August 2009MaintBotFixed group labels
31299view20:10, 13 August 2009MaintBotFixed text labels
30764view23:13, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF6BGeneProduct474855 (Entrez Gene)
ATMGeneProduct479450 (Entrez Gene)
CCNA1GeneProduct477302 (Entrez Gene)
CCNB1GeneProduct608420 (Entrez Gene)
CCND1GeneProduct449028 (Entrez Gene)
CCND2GeneProduct611782 (Entrez Gene)
CCND3GeneProduct608847 (Entrez Gene)
CCNE1GeneProduct484610 (Entrez Gene)
CCNE2GeneProduct487057 (Entrez Gene)
CCNG2GeneProduct478442 (Entrez Gene)
CCNHGeneProduct479156 (Entrez Gene)
CDC25AGeneProduct484780 (Entrez Gene)
CDC2AGeneProduct
CDC45GeneProduct486421 (Entrez Gene)
CDKGeneProduct
CDK4GeneProduct481131 (Entrez Gene)
CDK6GeneProduct609920 (Entrez Gene)
CDK7GeneProduct608441 (Entrez Gene)
CDKN1AGeneProduct474890 (Entrez Gene)
CDKN1BGeneProduct403429 (Entrez Gene)
CDKN1CGeneProduct
CDKN2AGeneProduct
CDKN2BGeneProduct481563 (Entrez Gene)
CDKN2CGeneProduct475359 (Entrez Gene)
CDKN2DGeneProduct611216 (Entrez Gene)
CREB1GeneProduct607922 (Entrez Gene)
CREB3GeneProduct611934 (Entrez Gene)
CREB3L1GeneProduct483636 (Entrez Gene)
CREB3L3GeneProduct485046 (Entrez Gene)
CREB3L4GeneProduct612303 (Entrez Gene)
CdkGeneProduct
CyclinDGeneProduct
E2F1GeneProduct485839 (Entrez Gene)
E2F3GeneProduct
E2F4GeneProduct611243 (Entrez Gene)
E2F5GeneProduct611103 (Entrez Gene)
E2F6GeneProduct609996 (Entrez Gene)
E2fGeneProduct
LOC100855664GeneProduct100855664 (Entrez Gene)
LOC100855690GeneProduct100855690 (Entrez Gene)
LOC100855704GeneProduct100855704 (Entrez Gene)
LOC100855728GeneProduct100855728 (Entrez Gene)
LOC100855917GeneProduct100855917 (Entrez Gene)
LOC100856079GeneProduct100856079 (Entrez Gene)
LOC100856421GeneProduct100856421 (Entrez Gene)
MCM2GeneProduct484622 (Entrez Gene)
MCM3GeneProduct481839 (Entrez Gene)
MCM4GeneProduct477871 (Entrez Gene)
MCM5GeneProduct610519 (Entrez Gene)
MCM6GeneProduct476131 (Entrez Gene)
MCM7GeneProduct479737 (Entrez Gene)
MDM2GeneProduct403693 (Entrez Gene)
MNAT1GeneProduct480346 (Entrez Gene)
MYCGeneProduct403924 (Entrez Gene)
MYT1GeneProduct485987 (Entrez Gene)
ORC2GeneProduct478868 (Entrez Gene)
ORC3GeneProduct474991 (Entrez Gene)
ORC4GeneProduct476141 (Entrez Gene)
ORC5GeneProduct609937 (Entrez Gene)
ORC6GeneProduct482492 (Entrez Gene)
PCNAGeneProduct477166 (Entrez Gene)
POLA2GeneProduct476025 (Entrez Gene)
POLE2GeneProduct608973 (Entrez Gene)
POLEGeneProduct486223 (Entrez Gene)
PRIM1GeneProduct607309 (Entrez Gene)
PRIM2GeneProduct474950 (Entrez Gene)
RB1GeneProduct476915 (Entrez Gene)
RBL1GeneProduct477221 (Entrez Gene)
RPA3GeneProduct481449 (Entrez Gene)
TFDP1GeneProduct607720 (Entrez Gene)
TFDP2GeneProduct477099 (Entrez Gene)
TP53GeneProduct403869 (Entrez Gene)
WEE1GeneProduct476847 (Entrez Gene)

Annotated Interactions

No annotated interactions
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