Classical Pathway for Pancreatic Cancer (Homo sapiens)

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Revision as of 17:33, 24 July 2012 by Pragat11 (Talk | contribs)
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FTLTretinoin DNASRC/NCOA1RAF1KRASMAPK1/MAPKsAKT1IKBA_HUMANIKKA_HUMANNFKB1STAT5A/STATsNuclear SubstratesCDK4/CDK6MDM2CDKN2AARF1CDK2CCND1TP53CCNE1CDN1A_HUMAN/CIP1Apoptosisp85PTENSERPINB10PIK3CARBL1BAX/BAXABID/BH3SMICASP3CASP8BCL2CYTC_HUMANAPAF1CASP9SMAD6/SMAD7SMAD4SMAD2/SMAD3APCE2F4IAPPPCAFSP1CDKN2BMYCG1 arrestBRCA1ATM/ATRBRCA2MAT1_HUMAN/ CDK7DNA RepairNDKA_HUMANRAD50PTTG1BUB1BGSK3A/ GSK3CTNNB1CREB1CBP_HUMANHNF4ACDK1CCNA2MAP3K5/ ASK1DAXXTGFB1FASLG/FASLFASTGFBR1CR2TBPSIRT1ERCC6RNA polXAB2ERCC2/XPDMAPK9MAPK3MAP2K1/ MEKsPRKCA/ PKCsPRKCACDKN1BEGFRCDC25C/ MPIP3CHK1_HUMANMAPK8GA45A_HUMAN/ GADD45IGFMRE11_HUMANABL1RAD52RAD51MYT1PLK1CHK2_HUMANCASP10FADDDFFADFFBCASP7DNA FragmentationNTRK1IL-3RIL3NGFCASP12CAPN1NT5C1AHBxLHBBDNFNTF3EGFFGFR1PDGFRA/ PDGFRPDGFA/PDGFSAPL1_HUMAN/ SAPLaIL1R1TRAF2SOS1GRB2PLA2G4A/ cPLA2STMN1TAU_HUMANIL11TNFRSF1ATNFMAPK4MAPK14/ p38MST1CUX1/ CASP/CDPMEF2CMAXDDIT3/ GADD153JUNDJUNMAPK7ANDR_HUMANBADGFRGFE2F1_HUMANRB1CC1RAC1STAT1PCNADNA-PKDNA Damage CheckpointTHBS1LTBP1FSTINHBALEFTY1NODALPITX2BIDQ6LD43_HUMAN/ GaMPIP3_HUMANDAG1AGPAT2/IP3PLCB_HUMANCAMK2A/ CAMPK2NOXA1BBC3/ PUMAPTK2/FAKPAK1NCK1CRKGR/NR3C1ACT2AG_HUMAN/TFFIIATFF1DNA MutationMDAPGH2_HUMAN/Cox1,2PRKAA1/ PKARAPGEF3RAP1A_HUMAN/Rap1BRF1TranslationFANCG/ FANCsPDK1STK11/LKB1CAMP/ AMPCAB39STRADA/ STRADPRKAA2/ AmpksCDK5R1p35EGR1ERCC3/XPBFANCN/ PALB2DCCMLH1MSH2MSH3MSH6TGFBR2SMOSHHG-ProteinsRAP1APARPTUBA1ATUBB1ConnexinRTKMTORFGFFGF2/ Growth FactorsESR1ADCY1ADORA2A/GPCRGNAS/GSPLNFKBP1AMMP9VEGF/ VEGF-APDE4B/PDE4BSSTR2SSTR5SSTR3RRM1RRM1TYMS/TSFKBP1BMAP3K4HSP90AB1/ HSPSEZH2CD82JUNBRHEBFKBP3GPCRsGPRC5AADORA1RARARXRsRARBTumor ProgressionTOP1ESR2Tamoxifen Dexamethasone ANXA1LIG1LIG3Teniposide Bleomycin Estradiol Triamcinolone AcetonideHydrocortisone Hydroxyurea TOP2A/TOP2Topotecan APPACHEDonepezil Amsacrine Gemcitabine Mitomycin EstroneSirolimus Theobromine Paclitaxel CamptothecinNiacinamideLanreotide Donepezil HDAC8Trichostatin A AfliberceptHPGDSPTGDSNocodazole


Description

No description

Comments

 
Pancreati

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Quality Tags

Ontology Terms

 

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History

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CompareRevisionActionTimeUserComment
49781view21:27, 25 July 2012Pragat11Deleted pathway:
49694view17:35, 24 July 2012Pragat11Specify description
49693view17:34, 24 July 2012Pragat11Specify description
49692view17:33, 24 July 2012Pragat11Periodical save, work in progress
49691view17:31, 24 July 2012Pragat11Specify description
49690view17:29, 24 July 2012Pragat11Specify description
49689view17:25, 24 July 2012Pragat11Specify description
49653view18:12, 23 July 2012Pragat11Specify description
49644view15:51, 23 July 2012Pragat11Specify description
49610view21:49, 22 July 2012Pragat11New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProductENSG00000097007 (Ensembl Human)
ACProtein
ACHEGeneProductENSG00000087085 (Ensembl Human)
ADCY1GeneProduct107 (Entrez Gene)
ADORA1GeneProductENSG00000163485 (Ensembl Human)
ADORA2A/GPCRGeneProductENSG00000128271 (Ensembl Human)
AGPAT2/IP3GeneProductENSG00000169692 (Ensembl Human)
AKT1GeneProduct207 (Entrez Gene)
ANDR_HUMANProteinP10275 (Uniprot/TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl Human)
APAF1GeneProductENSG00000120868 (Ensembl Human)
APCGeneProductENSG00000134982 (Ensembl Human)
APPGeneProductENSG00000142192 (Ensembl Human)
ARF1GeneProductENSG00000143761 (Ensembl Human)
ATM/ATRGeneProductENSG00000149311 (Ensembl Human)
Aflibercept
Amsacrine
Apoptosis
BADProtein
BAX/BAXAGeneProductENSG00000087088 (Ensembl Human)
BBC3/ PUMAGeneProductENSG00000105327 (Ensembl Human)
BCL2GeneProductENSG00000171791 (Ensembl Human)
BDNFGeneProductENSG00000176697 (Ensembl Human)
BID/BH3GeneProductENSG00000015475 (Ensembl Human)
BIDGeneProductENSG00000015475 (Ensembl Human)
BRCA1GeneProductENSG00000012048 (Ensembl Human)
BRCA2GeneProductENSG00000139618 (Ensembl Human)
BRF1GeneProductENSG00000185024 (Ensembl Human)
BUB1BGeneProductENSG00000156970 (Ensembl Human)
Bleomycin
CAB39GeneProductENSG00000135932 (Ensembl Human)
CAMK2A/ CAMPK2GeneProductENSG00000070808 (Ensembl Human)
CAMP/ AMPGeneProductENSG00000164047 (Ensembl Human)
CAPN1GeneProductENSG00000014216 (Ensembl Human)
CASP10GeneProductENSG00000003400 (Ensembl Human)
CASP12GeneProductENSG00000204403 (Ensembl Human)
CASP3GeneProductENSG00000164305 (Ensembl Human)
CASP7GeneProductENSG00000165806 (Ensembl Human)
CASP8GeneProductENSG00000064012 (Ensembl Human)
CASP9GeneProductENSG00000132906 (Ensembl Human)
CBP_HUMANProteinQ92793 (Uniprot/TrEMBL)
CCNA2GeneProductENSG00000145386 (Ensembl Human)
CCND1GeneProduct595 (Entrez Gene)
CCNE1GeneProductENSG00000105173 (Ensembl Human)
CD82GeneProductENSG00000085117 (Ensembl Human)
CDC25C/ MPIP3GeneProductENSG00000158402 (Ensembl Human)
CDK1Protein
CDK2GeneProductENSG00000123374 (Ensembl Human)
CDK4/CDK6GeneProductENSG00000135446 (Ensembl Human)
CDK5R1 p35Protein
CDKN1BGeneProductENSG00000111276 (Ensembl Human)
CDKN2AProtein
CDKN2BGeneProductENSG00000147883 (Ensembl Human)
CDN1A_HUMAN/CIP1ProteinP38936 (Uniprot/TrEMBL)
CHK1_HUMANProteinO14757 (Uniprot/TrEMBL)
CHK2_HUMANProteinO96017 (Uniprot/TrEMBL)
CR2Protein
CREB1GeneProductENSG00000118260 (Ensembl Human)
CRKGeneProductENSG00000167193 (Ensembl Human)
CTNNB1GeneProductENSG00000168036 (Ensembl Human)
CUX1/ CASP/CDPGeneProductENSG00000160967 (Ensembl Human)
CYTC_HUMANProteinP01034 (Uniprot/TrEMBL)
Camptothecin
ConnexinProtein
DAG1GeneProductENSG00000173402 (Ensembl Human)
DAXXGeneProductENSG00000204209 (Ensembl Human)
DCCGeneProductENSG00000187323 (Ensembl Human)
DDIT3/ GADD153GeneProductENSG00000175197 (Ensembl Human)
DFFAGeneProductENSG00000160049 (Ensembl Human)
DFFBGeneProductENSG00000169598 (Ensembl Human)
DNA
DNA Damage Checkpoint
DNA Fragmentation
DNA Mutation
DNA Repair
DNA-PK
Dexamethasone
Donepezil
E2F1_HUMANProteinQ01094 (Uniprot/TrEMBL)
E2F4GeneProductENSG00000205250 (Ensembl Human)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProductENSG00000146648 (Ensembl Human)
EGR1GeneProductENSG00000120738 (Ensembl Human)
ERCC2/XPDGeneProductENSG00000104884 (Ensembl Human)
ERCC3/XPBGeneProductENSG00000163161 (Ensembl Human)
ERCC6Protein
ESR1GeneProductENSG00000091831 (Ensembl Human)
ESR2GeneProductENSG00000140009 (Ensembl Human)
EZH2GeneProductENSG00000106462 (Ensembl Human)
Estradiol
Estrone
FADDGeneProductENSG00000168040 (Ensembl Human)
FANCG/ FANCsGeneProductENSG00000221829 (Ensembl Human)
FANCN/ PALB2Protein
FASGeneProductENSG00000026103 (Ensembl Human)
FASLG/FASLGeneProduct356 (Entrez Gene)
FGF2/ Growth FactorsGeneProductENSG00000138685 (Ensembl Human)
FGFGeneProductENSG00000113578 (Ensembl Human)
FGFR1GeneProductENSG00000077782 (Ensembl Human)
FKBP1AGeneProductENSG00000088832 (Ensembl Human)
FKBP1BGeneProductENSG00000119782 (Ensembl Human)
FKBP3GeneProductENSG00000100442 (Ensembl Human)
FSTGeneProductENSG00000134363 (Ensembl Human)
FTLGeneProductENSG00000087086 (Ensembl Human)
G-ProteinsGeneProductENSG00000152256 (Ensembl Human)
G1 arrestProtein
GA45A_HUMAN/ GADD45 ProteinP24522 (Uniprot/TrEMBL)
GFProtein
GFRProtein
GNAS/GSGeneProductENSG00000087460 (Ensembl Human)
GPCRsProtein
GPRC5AGeneProductENSG00000013588 (Ensembl Human)
GR/NR3C1Protein
GRB2GeneProductENSG00000177885 (Ensembl Human)
GSK3A/ GSK3GeneProductENSG00000105723 (Ensembl Human)
Gemcitabine
HBxProtein
HDAC8GeneProductENSG00000147099 (Ensembl Human)
HNF4AGeneProductENSG00000101076 (Ensembl Human)
HPGDSGeneProductENSG00000163106 (Ensembl Human)
HSP90AB1/ HSPSGeneProductENSG00000096384 (Ensembl Human)
Hydrocortisone
Hydroxyurea
IAPPGeneProductENSG00000121351 (Ensembl Human)
IGFProtein
IKBA_HUMANProteinP25963 (Uniprot/TrEMBL)
IKKA_HUMANProteinO15111 (Uniprot/TrEMBL)
IL-3RProtein
IL11GeneProductENSG00000095752 (Ensembl Human)
IL1R1GeneProductENSG00000115594 (Ensembl Human)
IL3GeneProductENSG00000164399 (Ensembl Human)
INHBAGeneProductENSG00000122641 (Ensembl Human)
JUNBGeneProductENSG00000171223 (Ensembl Human)
JUNDGeneProductENSG00000130522 (Ensembl Human)
JUNGeneProductENSG00000177606 (Ensembl Human)
KRASGeneProductENSG00000133703 (Ensembl Human)
LEFTY1GeneProductENSG00000243709 (Ensembl Human)
LHBProtein
LIG1GeneProductENSG00000105486 (Ensembl Human)
LIG3GeneProductENSG00000005156 (Ensembl Human)
LTBP1GeneProductENSG00000049323 (Ensembl Human)
Lanreotide
MAP2K1/ MEKsGeneProductENSG00000169032 (Ensembl Human)
MAP3K4GeneProductENSG00000085511 (Ensembl Human)
MAP3K5/ ASK1GeneProductENSG00000197442 (Ensembl Human)
MAPK1/MAPKsGeneProductENSG00000100030 (Ensembl Human)
MAPK14/ p38GeneProductENSG00000112062 (Ensembl Human)
MAPK3GeneProductENSG00000102882 (Ensembl Human)
MAPK4GeneProductENSG00000141639 (Ensembl Human)
MAPK7GeneProductENSG00000166484 (Ensembl Human)
MAPK8GeneProductENSG00000107643 (Ensembl Human)
MAPK9GeneProductENSG00000050748 (Ensembl Human)
MAT1_HUMAN/ CDK7ProteinP51948 (Uniprot/TrEMBL)
MAXGeneProductENSG00000125952 (Ensembl Human)
MDAProtein
MDM2GeneProductENSG00000135679 (Ensembl Human)
MEF2CGeneProductENSG00000081189 (Ensembl Human)
MLH1GeneProductENSG00000076242 (Ensembl Human)
MMP9GeneProductENSG00000137801 (Ensembl Human)
MPIP3_HUMANProteinP30307 (Uniprot/TrEMBL)
MRE11_HUMANProteinP49959 (Uniprot/TrEMBL)
MSH2GeneProductENSG00000095002 (Ensembl Human)
MSH3GeneProductENSG00000113318 (Ensembl Human)
MSH6GeneProductENSG00000116062 (Ensembl Human)
MST1GeneProductENSG00000173531 (Ensembl Human)
MTORProtein
MYCGeneProductENSG00000136997 (Ensembl Human)
MYT1GeneProduct4661 (Entrez Gene)
Mitomycin
NCK1GeneProduct4690 (Entrez Gene)
NDKA_HUMANProteinP15531 (Uniprot/TrEMBL)
NFKB1GeneProductENSG00000109320 (Ensembl Human)
NGFGeneProductENSG00000134259 (Ensembl Human)
NODALGeneProductENSG00000156574 (Ensembl Human)
NOXA1GeneProductENSG00000188747 (Ensembl Human)
NT5C1AGeneProductENSG00000116981 (Ensembl Human)
NTF3GeneProductENSG00000185652 (Ensembl Human)
NTRK1GeneProductENSG00000198400 (Ensembl Human)
Niacinamide
Nocodazole
Nuclear SubstratesProtein
PAK1GeneProductENSG00000149269 (Ensembl Human)
PARPGeneProductENSG00000015475 (Ensembl Human)
PCAFProtein
PCNAGeneProductENSG00000132646 (Ensembl Human)
PDE4B/PDE4B GeneProductENSG00000184588 (Ensembl Human)
PDGFA/PDGFGeneProduct5154 (Entrez Gene)
PDGFRA/ PDGFRGeneProduct5156 (Entrez Gene)
PDK1GeneProductENSG00000152256 (Ensembl Human)
PGH2_HUMAN/Cox1,2ProteinP35354 (Uniprot/TrEMBL)
PIK3CAGeneProductENSG00000121879 (Ensembl Human)
PITX2GeneProductENSG00000164093 (Ensembl Human)
PLA2G4A/ cPLA2GeneProduct5321 (Entrez Gene)
PLCB_HUMANProteinO15120 (Uniprot/TrEMBL)
PLK1GeneProductENSG00000166851 (Ensembl Human)
PLNGeneProductENSG00000198523 (Ensembl Human)
PRKAA1/ PKA GeneProductENSG00000249325 (Ensembl Human)
PRKAA2/ AmpksGeneProductENSG00000162409 (Ensembl Human)
PRKCA/ PKCsGeneProductENSG00000154229 (Ensembl Human)
PRKCAGeneProductENSG00000154229 (Ensembl Human)
PTENGeneProductENSG00000171862 (Ensembl Human)
PTGDSGeneProductENSG00000107317 (Ensembl Human)
PTK2/FAKGeneProductENSG00000169398 (Ensembl Human)
PTTG1GeneProductENSG00000164611 (Ensembl Human)
Paclitaxel
Q6LD43_HUMAN/ GaProteinQ6LD43 (Uniprot/TrEMBL)
RAC1GeneProduct5879 (Entrez Gene)
RAD50GeneProductENSG00000113522 (Ensembl Human)
RAD51GeneProductENSG00000051180 (Ensembl Human)
RAD52GeneProduct5893 (Entrez Gene)
RAF1GeneProductENSG00000132155 (Ensembl Human)
RAP1AGeneProductENSG00000116473 (Ensembl Human)
RAP1A_HUMAN/Rap1 ProteinP62834 (Uniprot/TrEMBL)
RAPGEF3GeneProductENSG00000079337 (Ensembl Human)
RARAGeneProductENSG00000131759 (Ensembl Human)
RARBGeneProductENSG00000077092 (Ensembl Human)
RB1CC1GeneProductENSG00000023287 (Ensembl Human)
RBL1GeneProductENSG00000080839 (Ensembl Human)
RHEBGeneProductENSG00000106615 (Ensembl Human)
RNA pol
RRM1GeneProductENSG00000167325 (Ensembl Human)
RTKProtein
RXRsGeneProductENSG00000186350 (Ensembl Human)
SAPL1_HUMAN/ SAPLaProteinQ6NUJ1 (Uniprot/TrEMBL)
SERPINB10GeneProductENSG00000242550 (Ensembl Human)
SHHGeneProductENSG00000164690 (Ensembl Human)
SIRT1GeneProductENSG00000096717 (Ensembl Human)
SMAD2/SMAD3GeneProductENSG00000175387 (Ensembl Human)
SMAD4GeneProductENSG00000141646 (Ensembl Human)
SMAD6/SMAD7GeneProductENSG00000137834 (Ensembl Human)
SMIProtein
SMOGeneProductENSG00000128602 (Ensembl Human)
SOS1GeneProductENSG00000115904 (Ensembl Human)
SP1GeneProductENSG00000185591 (Ensembl Human)
SRC/NCOA1GeneProductENSG00000197122 (Ensembl Human)
SSTR2GeneProductENSG00000180616 (Ensembl Human)
SSTR3GeneProductENSG00000183473 (Ensembl Human)
SSTR5GeneProductENSG00000162009 (Ensembl Human)
STAT1GeneProductENSG00000115415 (Ensembl Human)
STAT5A/STATsGeneProductENSG00000126561 (Ensembl Human)
STK11/LKB1GeneProductENSG00000118046 (Ensembl Human)
STMN1GeneProductENSG00000117632 (Ensembl Human)
STRADA/ STRADGeneProductENSG00000125695 (Ensembl Human)
Sirolimus
T2AG_HUMAN/TFFIIAProteinP52657 (Uniprot/TrEMBL)
TAU_HUMANProteinP10636 (Uniprot/TrEMBL)
TBPGeneProductENSG00000112592 (Ensembl Human)
TFF1GeneProductENSG00000160182 (Ensembl Human)
TGFB1GeneProductENSG00000105329 (Ensembl Human)
TGFBR1GeneProductENSG00000106799 (Ensembl Human)
TGFBR2GeneProductENSG00000163513 (Ensembl Human)
THBS1GeneProductENSG00000137801 (Ensembl Human)
TNFGeneProductENSG00000232810 (Ensembl Human)
TNFRSF1AGeneProductENSG00000067182 (Ensembl Human)
TOP1GeneProductENSG00000198900 (Ensembl Human)
TOP2A/TOP2GeneProductENSG00000131747 (Ensembl Human)
TP53GeneProductENSG00000141510 (Ensembl Human)
TRAF2GeneProductENSG00000127191 (Ensembl Human)
TUBA1AGeneProductENSG00000167552 (Ensembl Human)
TUBB1GeneProductENSG00000101162 (Ensembl Human)
TYMS/TSGeneProductENSG00000176890 (Ensembl Human)
Tamoxifen
Teniposide
Theobromine
Topotecan
Translation
Tretinoin
Triamcinolone Acetonide
Trichostatin A
Tumor Progression
VEGF/ VEGF-AGeneProductENSG00000112715 (Ensembl Human)
XAB2Protein
p85Protein

Annotated Interactions

No annotated interactions
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