Hybrid Pathway for Pancreatic Cancer (Homo sapiens)

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DataNodes

Name	Type	Database reference	Comment
ABL1	GeneProduct	ENSG00000097007 (Ensembl Human)
AC	Protein
ACHE	GeneProduct	ENSG00000087085 (Ensembl Human)
ADCY1	GeneProduct	107 (Entrez Gene)
ADORA1	GeneProduct	ENSG00000163485 (Ensembl Human)
ADORA2A/GPCR	GeneProduct	ENSG00000128271 (Ensembl Human)
AGPAT2/IP3	GeneProduct	ENSG00000169692 (Ensembl Human)
AKT1	GeneProduct	207 (Entrez Gene)
ANDR_HUMAN	Protein	P10275 (Uniprot/TrEMBL)
ANXA1	GeneProduct	ENSG00000135046 (Ensembl Human)
APAF1	GeneProduct	ENSG00000120868 (Ensembl Human)
APC	GeneProduct	ENSG00000134982 (Ensembl Human)
APP	GeneProduct	ENSG00000142192 (Ensembl Human)
ARF1	GeneProduct	ENSG00000143761 (Ensembl Human)
ASPP2_HUMAN	Protein	Q13625 (Uniprot/TrEMBL)
ATM/ATR	GeneProduct	ENSG00000149311 (Ensembl Human)
Aflibercept
Amsacrine
Amsacrine
Apoptosis
BAD	Protein
BAX/BAXA	GeneProduct	ENSG00000087088 (Ensembl Human)
BBC3/ PUMA	GeneProduct	ENSG00000105327 (Ensembl Human)
BCL2	GeneProduct	ENSG00000171791 (Ensembl Human)
BDNF	GeneProduct	ENSG00000176697 (Ensembl Human)
BID/BH3	GeneProduct	ENSG00000015475 (Ensembl Human)
BID	GeneProduct	ENSG00000015475 (Ensembl Human)
BLM	GeneProduct	ENSG00000197299 (Ensembl Human)
BRCA1	GeneProduct	ENSG00000012048 (Ensembl Human)
BRCA2	GeneProduct	ENSG00000139618 (Ensembl Human)
BRF1	GeneProduct	ENSG00000185024 (Ensembl Human)
BUB1B	GeneProduct	ENSG00000156970 (Ensembl Human)
Bleomycin
CAB39	GeneProduct	ENSG00000135932 (Ensembl Human)
CAMK2A/ CAMPK2	GeneProduct	ENSG00000070808 (Ensembl Human)
CAMP/ AMP	GeneProduct	ENSG00000164047 (Ensembl Human)
CAPN1	GeneProduct	ENSG00000014216 (Ensembl Human)
CASP10	GeneProduct	ENSG00000003400 (Ensembl Human)
CASP12	GeneProduct	ENSG00000204403 (Ensembl Human)
CASP3	GeneProduct	ENSG00000164305 (Ensembl Human)
CASP7	GeneProduct	ENSG00000165806 (Ensembl Human)
CASP8	GeneProduct	ENSG00000064012 (Ensembl Human)
CASP9	GeneProduct	ENSG00000132906 (Ensembl Human)
CBP_HUMAN	Protein	Q92793 (Uniprot/TrEMBL)
CCNA2	GeneProduct	ENSG00000145386 (Ensembl Human)
CCND1	GeneProduct	595 (Entrez Gene)
CCNE1	GeneProduct	ENSG00000105173 (Ensembl Human)
CD82	GeneProduct	ENSG00000085117 (Ensembl Human)
CDC25C/ MPIP3	GeneProduct	ENSG00000158402 (Ensembl Human)
CDK1	Protein
CDK2	GeneProduct	ENSG00000123374 (Ensembl Human)
CDK4/CDK6	GeneProduct	ENSG00000135446 (Ensembl Human)
CDK5R1 p35	Protein
CDKN1B	GeneProduct	ENSG00000111276 (Ensembl Human)
CDKN2A	Protein
CDKN2B	GeneProduct	ENSG00000147883 (Ensembl Human)
CDN1A_HUMAN/CIP1	Protein	P38936 (Uniprot/TrEMBL)
CHK1_HUMAN	Protein	O14757 (Uniprot/TrEMBL)
CHK2_HUMAN	Protein	O96017 (Uniprot/TrEMBL)
CR2	Protein
CREB1	GeneProduct	ENSG00000118260 (Ensembl Human)
CRHR1	GeneProduct	ENSG00000120088 (Ensembl Human)
CRK	GeneProduct	ENSG00000167193 (Ensembl Human)
CTNNB1	GeneProduct	ENSG00000168036 (Ensembl Human)
CUX1/ CASP/CDP	GeneProduct	ENSG00000160967 (Ensembl Human)
CYTC_HUMAN	Protein	P01034 (Uniprot/TrEMBL)
Camptothecin
Cobalt
Connexin	Protein
Corticosterone
DAG1	GeneProduct	ENSG00000173402 (Ensembl Human)
DAXX	GeneProduct	ENSG00000204209 (Ensembl Human)
DCC	GeneProduct	ENSG00000187323 (Ensembl Human)
DDIT3/ GADD153	GeneProduct	ENSG00000175197 (Ensembl Human)
DFFA	GeneProduct	ENSG00000160049 (Ensembl Human)
DFFB	GeneProduct	ENSG00000169598 (Ensembl Human)
DNA
DNA Damage Checkpoint
DNA Fragmentation
DNA Mutation
DNA Repair
DNA-PK
DPOLA_HUMAN	Protein	P09884 (Uniprot/TrEMBL)
Deferoxamine
Dexamethasone
Donepezil
E2AK2_HUMAN	Protein	P19525 (Uniprot/TrEMBL)
E2F1_HUMAN	Protein	Q01094 (Uniprot/TrEMBL)
E2F4	GeneProduct	ENSG00000205250 (Ensembl Human)
EGF	GeneProduct	1950 (Entrez Gene)
EGFR	GeneProduct	ENSG00000146648 (Ensembl Human)
EGR1	GeneProduct	ENSG00000120738 (Ensembl Human)
EP300	GeneProduct	2033 (Entrez Gene)
ERBB2	GeneProduct	ENSG00000141736 (Ensembl Human)
ERCC2/XPD	GeneProduct	ENSG00000104884 (Ensembl Human)
ERCC3/XPB	GeneProduct	ENSG00000163161 (Ensembl Human)
ERCC6	Protein
ESR1	GeneProduct	ENSG00000091831 (Ensembl Human)
ESR2	GeneProduct	ENSG00000140009 (Ensembl Human)
EZH2	GeneProduct	ENSG00000106462 (Ensembl Human)
Estradiol
Estrone
FADD	GeneProduct	ENSG00000168040 (Ensembl Human)
FANCG/ FANCs	GeneProduct	ENSG00000221829 (Ensembl Human)
FANCN/ PALB2	Protein
FAS	GeneProduct	ENSG00000026103 (Ensembl Human)
FASLG/FASL	GeneProduct	356 (Entrez Gene)
FGF2/ Growth Factors	GeneProduct	ENSG00000138685 (Ensembl Human)
FGF	GeneProduct	ENSG00000113578 (Ensembl Human)
FGFR1	GeneProduct	ENSG00000077782 (Ensembl Human)
FKBP1A	GeneProduct	ENSG00000088832 (Ensembl Human)
FKBP1B	GeneProduct	ENSG00000119782 (Ensembl Human)
FKBP3	GeneProduct	ENSG00000100442 (Ensembl Human)
FST	GeneProduct	ENSG00000134363 (Ensembl Human)
FTL	GeneProduct	ENSG00000087086 (Ensembl Human)
G-Proteins	GeneProduct	ENSG00000152256 (Ensembl Human)
G1 arrest	Protein
GA45A_HUMAN/ GADD45	Protein	P24522 (Uniprot/TrEMBL)
GF	Protein
GFR	Protein
GNAS/GS	GeneProduct	ENSG00000087460 (Ensembl Human)
GPCRs	Protein
GPRC5A	GeneProduct	ENSG00000013588 (Ensembl Human)
GR/NR3C1	Protein
GRB2	GeneProduct	ENSG00000177885 (Ensembl Human)
GSK3A/ GSK3	GeneProduct	ENSG00000105723 (Ensembl Human)
Gemcitabine
Gramicidin
HBx	Protein
HDAC8	GeneProduct	ENSG00000147099 (Ensembl Human)
HNF4A	GeneProduct	ENSG00000101076 (Ensembl Human)
HPGDS	GeneProduct	ENSG00000163106 (Ensembl Human)
HSP90AB1/ HSPS	GeneProduct	ENSG00000096384 (Ensembl Human)
Hydrocortisone
Hydroxyurea
IAPP	GeneProduct	ENSG00000121351 (Ensembl Human)
IASPP_HUMAN	Protein	Q8WUF5 (Uniprot/TrEMBL)
IBP3_HUMAN	Protein	P17936 (Uniprot/TrEMBL)
IGF	Protein
IKBA_HUMAN	Protein	P25963 (Uniprot/TrEMBL)
IKKA_HUMAN	Protein	O15111 (Uniprot/TrEMBL)
IL-3R	Protein
IL11	GeneProduct	ENSG00000095752 (Ensembl Human)
IL1R1	GeneProduct	ENSG00000115594 (Ensembl Human)
IL3	GeneProduct	ENSG00000164399 (Ensembl Human)
INHBA	GeneProduct	ENSG00000122641 (Ensembl Human)
Interferons
JUNB	GeneProduct	ENSG00000171223 (Ensembl Human)
JUND	GeneProduct	ENSG00000130522 (Ensembl Human)
JUN	GeneProduct	ENSG00000177606 (Ensembl Human)
KRAS	GeneProduct	ENSG00000133703 (Ensembl Human)
LEFTY1	GeneProduct	ENSG00000243709 (Ensembl Human)
LHB	Protein
LIG1	GeneProduct	ENSG00000105486 (Ensembl Human)
LIG3	GeneProduct	ENSG00000005156 (Ensembl Human)
LTBP1	GeneProduct	ENSG00000049323 (Ensembl Human)
Lanreotide
MAP2K1/ MEKs	GeneProduct	ENSG00000169032 (Ensembl Human)
MAP3K4	GeneProduct	ENSG00000085511 (Ensembl Human)
MAP3K5/ ASK1	GeneProduct	ENSG00000197442 (Ensembl Human)
MAPK1/MAPKs	GeneProduct	ENSG00000100030 (Ensembl Human)
MAPK14/ p38	GeneProduct	ENSG00000112062 (Ensembl Human)
MAPK3	GeneProduct	ENSG00000102882 (Ensembl Human)
MAPK4	GeneProduct	ENSG00000141639 (Ensembl Human)
MAPK7	GeneProduct	ENSG00000166484 (Ensembl Human)
MAPK8	GeneProduct	ENSG00000107643 (Ensembl Human)
MAPK9	GeneProduct	ENSG00000050748 (Ensembl Human)
MAT1_HUMAN/ CDK7	Protein	P51948 (Uniprot/TrEMBL)
MAX	GeneProduct	ENSG00000125952 (Ensembl Human)
MDA	Protein
MDM2	GeneProduct	ENSG00000135679 (Ensembl Human)
MDR1_HUMAN	Protein	P08183 (Uniprot/TrEMBL)
MEF2C	GeneProduct	ENSG00000081189 (Ensembl Human)
MLH1	GeneProduct	ENSG00000076242 (Ensembl Human)
MMP9	GeneProduct	ENSG00000137801 (Ensembl Human)
MPIP3_HUMAN	Protein	P30307 (Uniprot/TrEMBL)
MRE11_HUMAN	Protein	P49959 (Uniprot/TrEMBL)
MSH2	GeneProduct	ENSG00000095002 (Ensembl Human)
MSH3	GeneProduct	ENSG00000113318 (Ensembl Human)
MSH6	GeneProduct	ENSG00000116062 (Ensembl Human)
MST1	GeneProduct	ENSG00000173531 (Ensembl Human)
MTOR	Protein
MYC	GeneProduct	ENSG00000136997 (Ensembl Human)
MYT1	GeneProduct	4661 (Entrez Gene)
Methyl Methanesulfonate
Mitomycin
NCK1	GeneProduct	4690 (Entrez Gene)
NDKA_HUMAN	Protein	P15531 (Uniprot/TrEMBL)
NFKB1	GeneProduct	ENSG00000109320 (Ensembl Human)
NGF	GeneProduct	ENSG00000134259 (Ensembl Human)
NODAL	GeneProduct	ENSG00000156574 (Ensembl Human)
NOXA1	GeneProduct	ENSG00000188747 (Ensembl Human)
NT5C1A	GeneProduct	ENSG00000116981 (Ensembl Human)
NTF3	GeneProduct	ENSG00000185652 (Ensembl Human)
NTRK1	GeneProduct	ENSG00000198400 (Ensembl Human)
Niacinamide
Nocodazole
Nuclear Substrates	Protein
PAK1	GeneProduct	ENSG00000149269 (Ensembl Human)
PARP	GeneProduct	ENSG00000015475 (Ensembl Human)
PCAF	Protein
PCNA	GeneProduct	ENSG00000132646 (Ensembl Human)
PDE4B/PDE4B	GeneProduct	ENSG00000184588 (Ensembl Human)
PDGFA/PDGF	GeneProduct	5154 (Entrez Gene)
PDGFRA/ PDGFR	GeneProduct	5156 (Entrez Gene)
PDK1	GeneProduct	ENSG00000152256 (Ensembl Human)
PGH2_HUMAN/Cox1	Protein	P35354 (Uniprot/TrEMBL)
PIAS1	GeneProduct	ENSG00000033800 (Ensembl Human)
PIK3CA	GeneProduct	ENSG00000121879 (Ensembl Human)
PITX2	GeneProduct	ENSG00000164093 (Ensembl Human)
PLA2G4A/ cPLA2	GeneProduct	5321 (Entrez Gene)
PLCB_HUMAN	Protein	O15120 (Uniprot/TrEMBL)
PLK1	GeneProduct	ENSG00000166851 (Ensembl Human)
PLN	GeneProduct	ENSG00000198523 (Ensembl Human)
PML	GeneProduct	ENSG00000140464 (Ensembl Human)
PRKAA1/ PKA	GeneProduct	ENSG00000249325 (Ensembl Human)
PRKAA2/ Ampks	GeneProduct	ENSG00000162409 (Ensembl Human)
PRKCA/ PKCs	GeneProduct	ENSG00000154229 (Ensembl Human)
PRKCA	GeneProduct	ENSG00000154229 (Ensembl Human)
PTEN	GeneProduct	ENSG00000171862 (Ensembl Human)
PTGDS	GeneProduct	ENSG00000107317 (Ensembl Human)
PTGS2	GeneProduct	ENSG00000073756 (Ensembl Human)
PTK2/FAK	GeneProduct	ENSG00000169398 (Ensembl Human)
PTTG1	GeneProduct	ENSG00000164611 (Ensembl Human)
Paclitaxel
Q6LD43_HUMAN/ Ga	Protein	Q6LD43 (Uniprot/TrEMBL)
RAC1	GeneProduct	5879 (Entrez Gene)
RAD50	GeneProduct	ENSG00000113522 (Ensembl Human)
RAD51	GeneProduct	ENSG00000051180 (Ensembl Human)
RAD52	GeneProduct	5893 (Entrez Gene)
RAF1	GeneProduct	ENSG00000132155 (Ensembl Human)
RAP1A	GeneProduct	ENSG00000116473 (Ensembl Human)
RAP1A_HUMAN/Rap1	Protein	P62834 (Uniprot/TrEMBL)
RAPGEF3	GeneProduct	ENSG00000079337 (Ensembl Human)
RARA	GeneProduct	ENSG00000131759 (Ensembl Human)
RARB	GeneProduct	ENSG00000077092 (Ensembl Human)
RB1CC1	GeneProduct	ENSG00000023287 (Ensembl Human)
RBL1	GeneProduct	ENSG00000080839 (Ensembl Human)
RHEB	GeneProduct	ENSG00000106615 (Ensembl Human)
RNA pol
RPA1_HUMAN	Protein	O95602 (Uniprot/TrEMBL)
RRM1	GeneProduct	ENSG00000167325 (Ensembl Human)
RTK	Protein
RXRs	GeneProduct	ENSG00000186350 (Ensembl Human)
SAPL1_HUMAN/ SAPLa	Protein	Q6NUJ1 (Uniprot/TrEMBL)
SERPINB10	GeneProduct	ENSG00000242550 (Ensembl Human)
SHH	GeneProduct	ENSG00000164690 (Ensembl Human)
SIRT1	GeneProduct	ENSG00000096717 (Ensembl Human)
SMAD2/SMAD3	GeneProduct	ENSG00000175387 (Ensembl Human)
SMAD4	GeneProduct	ENSG00000141646 (Ensembl Human)
SMAD6/SMAD7	GeneProduct	ENSG00000137834 (Ensembl Human)
SMI	Protein
SMO	GeneProduct	ENSG00000128602 (Ensembl Human)
SOS1	GeneProduct	ENSG00000115904 (Ensembl Human)
SP1	GeneProduct	ENSG00000185591 (Ensembl Human)
SRC/NCOA1	GeneProduct	ENSG00000197122 (Ensembl Human)
SSTR2	GeneProduct	ENSG00000180616 (Ensembl Human)
SSTR3	GeneProduct	ENSG00000183473 (Ensembl Human)
SSTR5	GeneProduct	ENSG00000162009 (Ensembl Human)
STAT1	GeneProduct	ENSG00000115415 (Ensembl Human)
STAT5A/STATs	GeneProduct	ENSG00000126561 (Ensembl Human)
STK11/LKB1	GeneProduct	ENSG00000118046 (Ensembl Human)
STMN1	GeneProduct	ENSG00000117632 (Ensembl Human)
STRADA/ STRAD	GeneProduct	ENSG00000125695 (Ensembl Human)
Sirolimus
T2AG_HUMAN/TFFIIA	Protein	P52657 (Uniprot/TrEMBL)
TAU_HUMAN	Protein	P10636 (Uniprot/TrEMBL)
TBP	GeneProduct	ENSG00000112592 (Ensembl Human)
TFF1	GeneProduct	ENSG00000160182 (Ensembl Human)
TGFB1	GeneProduct	ENSG00000105329 (Ensembl Human)
TGFBR1	GeneProduct	ENSG00000106799 (Ensembl Human)
TGFBR2	GeneProduct	ENSG00000163513 (Ensembl Human)
THBS1	GeneProduct	ENSG00000137801 (Ensembl Human)
TNF	GeneProduct	ENSG00000232810 (Ensembl Human)
TNFRSF1A	GeneProduct	ENSG00000067182 (Ensembl Human)
TOP1	GeneProduct	ENSG00000198900 (Ensembl Human)
TOP2A/TOP2	GeneProduct	ENSG00000131747 (Ensembl Human)
TP53	GeneProduct	ENSG00000141510 (Ensembl Human)
TRAF2	GeneProduct	ENSG00000127191 (Ensembl Human)
TUBA1A	GeneProduct	ENSG00000167552 (Ensembl Human)
TUBB1	GeneProduct	ENSG00000101162 (Ensembl Human)
TYMS/TS	GeneProduct	ENSG00000176890 (Ensembl Human)
Tamoxifen
Teniposide
Theobromine
Topotecan
Translation
Tretinoin
Triamcinolone Acetonide
Trichostatin A
Tumor Progression
UCN	GeneProduct	ENSG00000163794 (Ensembl Human)
VEGF/ VEGF-A	GeneProduct	ENSG00000112715 (Ensembl Human)
WRN	GeneProduct	ENSG00000165392 (Ensembl Human)
WT1	GeneProduct	ENSG00000184937 (Ensembl Human)
XAB2	Protein
p85	Protein

Annotated Interactions