Androgen receptor network in prostate cancer (Homo sapiens)

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ARFKBP5MYCAR* 3-beta-OH-delta-steroid DH & Steroid isomerase =*** Estradiol-17-beta DH = DHB****HSD3B2CYP17A1HSD3B1HSD3B1HSD17B717-alpha-OH-ProgesteroneDihydrotestosteroneHSD3B1HSD3B1AndrostenedioneHSD3B1Hydroxyprogesterone aldolaseHSD3B1ProgesteroneEstradiolHSD3B2TestosteroneHSD3B1EstroneHSD3B1HSD3B1AndrostenediolHSD3B1F13BGlucocortocoid SynthesisHSD3B1HSD3B1HSD17B4HSD3B1Hydroxyprogesterone aldolaseHSD3B1HSD3B1Hydroxyprogesterone aldolaseSteroid-19-HydroxylaseHSD3B2PregnenoloneCYP17A1HSD3B1HSD3B2HSD3B1HSD17B2HSD3B1HSD3B1HSD17B317-alpha-OH-PregnenoloneHSD17B1HSD3B1CholesterolHSD3B1Mineralocortocoid SynthesisSteroid-19-Hydroxylase


Description

P53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high level of sequence homology in its DNA binding domain. The complexity of the family has been enriched by the alternatively spliced forms of the genes. At present pathway, the alternatively spliced forms of p63 and p73 and how they interact with p53 are shown . However, little is known about the transcriptional regulation of p53 family members. Further studies will tell us whether the three genes of the family also share others regulatory activities.

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Ontology Terms

 

Bibliography

  1. Liu LZ, Li C, Chen Q, Jing Y, Carpenter R, Jiang Y, Kung HF, Lai L, Jiang BH; ''MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression.''; PLoS One, 2011 PubMed Europe PMC Scholia
  2. Schramedei K, Mörbt N, Pfeifer G, Läuter J, Rosolowski M, Tomm JM, von Bergen M, Horn F, Brocke-Heidrich K; ''MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4.''; Oncogene, 2011 PubMed Europe PMC Scholia
  3. Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, Perner S, Demichelis F, Helgeson BE, Laxman B, Morris DS, Cao Q, Cao X, Andrén O, Fall K, Johnson L, Wei JT, Shah RB, Al-Ahmadie H, Eastham JA, Eggener SE, Fine SW, Hotakainen K, Stenman UH, Tsodikov A, Gerald WL, Lilja H, Reuter VE, Kantoff PW, Scardino PT, Rubin MA, Bjartell AS, Chinnaiyan AM; ''The role of SPINK1 in ETS rearrangement-negative prostate cancers.''; Cancer Cell, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134233view11:42, 17 July 2024EweitzDisentangle interaction, avoid label-interaction occlusion
134232view11:39, 17 July 2024EweitzIncrease font size on all nodes, for readability
134231view11:29, 17 July 2024EweitzEconomize layout
134230view11:21, 17 July 2024EweitzEconomize layout
134229view10:59, 17 July 2024EweitzImprove contrast for readability, standardize case
134228view10:57, 17 July 2024EweitzEconomize layout
134227view10:43, 17 July 2024EweitzEconomize layout
134226view10:30, 17 July 2024EweitzEconomize layout
134225view10:25, 17 July 2024EweitzEconomize layout
134224view10:20, 17 July 2024EweitzEconomize layout
134223view10:13, 17 July 2024EweitzFix modeling, refine interaction connection point
134222view10:08, 17 July 2024EweitzEconomize organelle shape
134216view08:00, 17 July 2024EgonwRemoved template comments
127838view04:43, 23 December 2023EweitzMove two genes back into circle, refine case
127837view04:38, 23 December 2023EweitzFurther economize layout
127836view03:39, 23 December 2023EweitzFurther economize layout
127834view03:13, 23 December 2023EweitzEconomize layout, fix typo
125525view17:04, 25 February 2023EgonwUpdated a data source
123536view14:39, 2 August 2022EgonwMade two pathways clickable
121719view15:54, 26 February 2022EweitzRefine case, use gene symbols
116551view12:49, 7 May 2021EweitzModified title
115243view17:15, 7 February 2021EgonwReplaced links to a deleted pathway with an equivalent existing pathway
108261view14:47, 3 December 2019L DupuisConnected unconnected line
108107view10:17, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106708view13:14, 17 September 2019MaintBotHMDB identifier normalization
98360view06:13, 24 August 2018EgonwUpdated the MIR21 identifier.
98155view13:48, 26 July 2018Fehrhartlayout
96290view15:39, 7 March 2018Fehrhartconnected lines-replace by graphic item
96015view15:04, 15 February 2018MkutmonModified description
96014view15:03, 15 February 2018MkutmonModified description
96013view15:00, 15 February 2018MkutmonModified title
85556view08:33, 29 May 2016EgonwReplaced a mim-conversion with Arrow.
84985view18:49, 4 April 2016AlexanderPicoreplaced mim-conversion with mim-transcription-translation for gene to protein
80439view20:55, 22 June 2015KhanspersAdded mir21 targeting of SMARCA4
80426view18:58, 22 June 2015KhanspersAdded mir21 targeting of PTEN and connected interactions
79838view07:57, 18 April 2015EgonwFixed the metabolite label.
79823view07:44, 17 April 2015EgonwReplaced "EC Number" with "Enzyme Nomenclature" as data source (fixing the links out).
73838view00:09, 26 February 2014MaintBotupdated schema
71495view19:19, 17 October 2013MaintBotUpdated data sources
69730view08:23, 11 July 2013EgonwHydroxyprogesterone aldolase is not a metabolite.
67609view11:32, 26 June 2013DdiglesOntology Term : 'prostate cancer pathway' added !
59165view18:25, 22 February 2013MaintBotUpdated Ensembl data source
54728view19:59, 7 December 2012MaintBotadded p38
54672view21:25, 6 December 2012RobertbaertschPeriodical save, work in progress
54277view20:35, 26 November 2012RobertbaertschPeriodical save, work in progress
54276view20:15, 26 November 2012RobertbaertschPeriodical save, work in progress
54275view19:39, 26 November 2012RobertbaertschPeriodical save, work in progress
54241view08:35, 24 November 2012RobertbaertschPeriodical save, work in progress
53136view01:55, 30 October 2012MaintBotModified categories
50365view22:16, 13 August 2012PgfebboOntology Term : 'prostate cancer' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
17-alpha-OH-PregnenoloneMetaboliteHMDB00363 (HMDB)
17-alpha-OH-ProgesteroneMetaboliteHMDB00374 (HMDB)
ARGeneProduct367 (Entrez Gene) AR
AndrostenediolMetaboliteHMDB05849 (HMDB)
AndrostenedioneMetabolite63-05-8 (CAS)
CYP17A1GeneProduct1586 (Entrez Gene)
CholesterolMetabolite57-88-5 (CAS)
DihydrotestosteroneMetaboliteHMDB02961 (HMDB)
EstradiolMetabolite57-91-0 (CAS)
EstroneMetabolite53-16-7 (CAS)
F13BGeneProduct2165 (Entrez Gene)
FKBP5GeneProduct2289 (Entrez Gene)
Glucocortocoid SynthesisPathwayWP237 (WikiPathways)
HSD17B1GeneProduct3292 (Entrez Gene)
HSD17B2GeneProduct3294 (Entrez Gene)
HSD17B3GeneProduct3293 (Entrez Gene)
HSD17B4GeneProduct3295 (Entrez Gene)
HSD17B7GeneProduct51478 (Entrez Gene)
HSD3B1GeneProduct3283 (Entrez Gene)
HSD3B2GeneProduct3284 (Entrez Gene)
Hydroxyprogesterone aldolaseGeneProduct4.1.2.30 (EC Number)
Hydroxyprogesterone aldolaseMetabolite53-43-0 (CAS)
MYCGeneProductENSG00000136997 (Ensembl Human)
Mineralocortocoid SynthesisPathwayWP237 (WikiPathways)
PregnenoloneMetabolite145-13-1 (CAS)
ProgesteroneMetabolite57-83-0 (CAS)
Steroid-19-HydroxylaseGeneProductENSG00000120054 (Ensembl Human)
TestosteroneMetabolite58-22-0 (CAS)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2263"
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