Glioblastoma signaling (Homo sapiens)
From WikiPathways
Description
The most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core pathways by TCGA, The Cancer Genome Atlas (see Bibliography). Assembled from literature and public pathway database resources, this representation can easily be kept up-to-date at WikiPathways.org.
Sources: cBio Cancer Genomics Portal
Quality Tags
Ontology Terms
Saving...Bibliography
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- Kwak HJ, Kim YJ, Chun KR, Woo YM, Park SJ, Jeong JA, Jo SH, Kim TH, Min HS, Chae JS, Choi EJ, Kim G, Shin SH, Gwak HS, Kim SK, Hong EK, Lee GK, Choi KH, Kim JH, Yoo H, Park JB, Lee SH; ''Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas.''; Oncogene, 2011 PubMed Europe PMC Scholia
- Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT; ''Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
- Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
- Zhou X, Ren Y, Moore L, Mei M, You Y, Xu P, Wang B, Wang G, Jia Z, Pu P, Zhang W, Kang C; ''Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status.''; Lab Invest, 2010 PubMed Europe PMC Scholia
- Liu X, Zhang Z, Sun L, Chai N, Tang S, Jin J, Hu H, Nie Y, Wang X, Wu K, Jin H, Fan D; ''MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4.''; Carcinogenesis, 2011 PubMed Europe PMC Scholia
- ''Comprehensive genomic characterization defines human glioblastoma genes and core pathways.''; Nature, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| GeneProduct | |||
| AKT1 | GeneProduct | ENSG00000142208 (Ensembl Human)  | |
| AKT2 | GeneProduct | ENSG00000105221 (Ensembl Human) | |
| AKT3 | GeneProduct | ENSG00000117020 (Ensembl Human) | |
| ARAF | GeneProduct | ENSG00000078061 (Ensembl Human) | |
| ARF | GeneProduct | ENSG00000147889 (Ensembl Human) | |
| ATM | GeneProduct | ENSG00000149311 (Ensembl Human) | |
| Apoptosis | Pathway | ||
| BRAF | GeneProduct | ENSG00000157764 (Ensembl Human) | |
| BRCA1 | GeneProduct | ENSG00000012048 (Ensembl Human) | |
| BRCA2 | GeneProduct | ENSG00000139618 (Ensembl Human) | |
| CBL | GeneProduct | ENSG00000110395 (Ensembl Human) | |
| CCND1 | GeneProduct | ENSG00000110092 (Ensembl Human) | |
| CCND2 | GeneProduct | ENSG00000118971 (Ensembl Human) | |
| CCNE1 | GeneProduct | ENSG00000105173 (Ensembl Human) | |
| CDK2 | GeneProduct | ENSG00000123374 (Ensembl Human) | |
| CDK4 | GeneProduct | ENSG00000135446 (Ensembl Human) | |
| CDK6 | GeneProduct | ENSG00000105810 (Ensembl Human) | |
| CDKN1A | GeneProduct | ENSG00000124762 (Ensembl Human) | |
| CDKN1B | GeneProduct | ENSG00000111276 (Ensembl Human) | |
| CDKN2B | GeneProduct | ENSG00000147883 (Ensembl Human) | |
| CDKN2C | GeneProduct | ENSG00000123080 (Ensembl Human) | |
| Cell Cycle Progression | Pathway | ||
| Cell Migration | Pathway | ||
| Cell Survival | Pathway | ||
| DNA Repair | Pathway | ||
| E2F1 | GeneProduct | ENSG00000101412 (Ensembl Human) | |
| EGFR | GeneProduct | ENSG00000146648 (Ensembl Human) | |
| EP300 | GeneProduct | ENSG00000100393 (Ensembl Human) | |
| ERBB2 | GeneProduct | ENSG00000141736 (Ensembl Human) | |
| ERBB3 | GeneProduct | ENSG00000065361 (Ensembl Human) | |
| ERRFI1 | GeneProduct | ENSG00000116285 (Ensembl Human) | |
| FGFR1 | GeneProduct | ENSG00000077782 (Ensembl Human) | |
| FGFR2 | GeneProduct | ENSG00000066468 (Ensembl Human) | |
| FOXO1 | GeneProduct | ENSG00000150907 (Ensembl Human) | |
| FOXO3 | GeneProduct | ENSG00000118689 (Ensembl Human) | |
| FOXO4 | GeneProduct | ENSG00000184481 (Ensembl Human) | |
| G1/S Progression | Pathway | ||
| G2/M Arrest | Pathway | ||
| GAB1 | GeneProduct | ENSG00000109458 (Ensembl Human) | |
| GRB2 | GeneProduct | ENSG00000177885 (Ensembl Human) | |
| HRAS | GeneProduct | ENSG00000174775 (Ensembl Human) | |
| IGF1R | GeneProduct | ENSG00000140443 (Ensembl Human) | |
| IRS1 | GeneProduct | ENSG00000169047 (Ensembl Human) | |
| KRAS | GeneProduct | ENSG00000133703 (Ensembl Human) | |
| LPA | Metabolite | 52288 (ChEBI) | |
| MAP2K1 | GeneProduct | ENSG00000169032 (Ensembl Human) | |
| MAP2K2 | GeneProduct | ENSG00000126934 (Ensembl Human) | |
| MAP2K3 | GeneProduct | ENSG00000034152 (Ensembl Human) | |
| MAP2K4 | GeneProduct | ENSG00000065559 (Ensembl Human) | |
| MAP2K5 | GeneProduct | ENSG00000137764 (Ensembl Human) | |
| MAP2K6 | GeneProduct | ENSG00000108984 (Ensembl Human) | |
| MAP2K7 | GeneProduct | ENSG00000076984 (Ensembl Human) | |
| MAPK1 | GeneProduct | ENSG00000100030 (Ensembl Human) | |
| MAPK3 | GeneProduct | ENSG00000102882 (Ensembl Human) | |
| MDM2 | GeneProduct | ENSG00000135679 (Ensembl Human) | |
| MDM4 | GeneProduct | ENSG00000198625 (Ensembl Human) | |
| MET | GeneProduct | ENSG00000105976 (Ensembl Human) | |
| MSH6 | GeneProduct | ENSG00000116062 (Ensembl Human) | |
| NF1 | GeneProduct | ENSG00000196712 (Ensembl Human) | |
| NRAS | GeneProduct | ENSG00000213281 (Ensembl Human) | |
| P16 | GeneProduct | ENSG00000147889 (Ensembl Human) | |
| PDGFRA | GeneProduct | ENSG00000134853 (Ensembl Human) | |
| PDGFRB | GeneProduct | ENSG00000113721 (Ensembl Human) | |
| PDPK1 | GeneProduct | ENSG00000140992 (Ensembl Human) | |
| PI(3)P | Metabolite | 26034 (ChEBI) | |
| PIK3C2A | GeneProduct | ENSG00000011405 (Ensembl Human) | |
| PIK3C2B | GeneProduct | ENSG00000133056 (Ensembl Human) | |
| PIK3C2G | GeneProduct | ENSG00000139144 (Ensembl Human) | |
| PIK3CA | GeneProduct | ENSG00000121879 (Ensembl Human) | |
| PIK3CB | GeneProduct | ENSG00000051382 (Ensembl Human) | |
| PIK3CD | GeneProduct | ENSG00000171608 (Ensembl Human) | |
| PIK3CG | GeneProduct | ENSG00000105851 (Ensembl Human) | |
| PIK3R1 | GeneProduct | ENSG00000145675 (Ensembl Human) | |
| PIK3R2 | GeneProduct | ENSG00000105647 (Ensembl Human) | |
| PIP3 | Metabolite | 16618 (ChEBI) | |
| PLCG1 | GeneProduct | ENSG00000124181 (Ensembl Human) | |
| PLCG2 | GeneProduct | ENSG00000197943 (Ensembl Human) | |
| PRKC1 | GeneProduct | ||
| PRKCA | GeneProduct | ENSG00000154229 (Ensembl Human) | |
| PRKCB1 | GeneProduct | ||
| PRKCD | GeneProduct | ENSG00000163932 (Ensembl Human) | |
| PRKCG | GeneProduct | ENSG00000126583 (Ensembl Human) | |
| PRKCH | GeneProduct | ENSG00000027075 (Ensembl Human) | |
| PRKCQ | GeneProduct | ENSG00000065675 (Ensembl Human) | |
| PRKCZ | GeneProduct | ENSG00000067606 (Ensembl Human) | |
| PTEN | GeneProduct | ENSG00000171862 (Ensembl Human) | |
| RAF1 | GeneProduct | ENSG00000132155 (Ensembl Human) | |
| RB1 | GeneProduct | ENSG00000139687 (Ensembl Human) | |
| SPRY2 | GeneProduct | ENSG00000136158 (Ensembl Human) | |
| SRC | GeneProduct | ENSG00000197122 (Ensembl Human) | |
| TP53 | GeneProduct | ENSG00000141510 (Ensembl Human) | |
| TSC1 | GeneProduct | ENSG00000165699 (Ensembl Human) | |
| TSC2 | GeneProduct | ENSG00000103197 (Ensembl Human) |
Annotated Interactions
No annotated interactions
