Corticotropin-releasing hormone (Homo sapiens)

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PRKCQP2cGMPNONUActivated inkeratinocytesthymocytesCorticotropin-Releasing Hormone Signaling PathwayCyclaseInhibited inmelanocytespituitary corticotrophspituitary tumor cellsFatty acidoxidationGuanylateCYCYRegulation of CRHENNUProinflammatory effect in leukocutesPlacentalvesselvasodilationNUAdenylateNUCYENDesensitizationIncreased gap junctionsNeuroprotectionVEGF releasein mast cellsFASL releasein PC12 cellsCYPMRecycling of receptorsApoptosis inMicroglial cellsHippocampal neuronsProstate cancer cellsNUCYDehydroepiandrosterone sulfate and cortisol productionKeratinocytedifferentiationand proliferationCell survivalNUCYNUPMCYNeuronalsurvivalInhibits Cell proliferationJUNBRHOAJUNIL18TLR4FOSPRKAA2NCOA2NR4A1PRKAIL8JUNDACACACRHTRIM28CRHBPNR4A1NOS3PTK2FOSBFOSL1FOSL2SP1CACNA1HPT172S80PRKCIPPRKCDPHSD3B1TCF4TFAP2ACTNNB1ACTH productionMAPK3T204T202IL2KRT1MAPK9T183Y185NR4A2CRHR2MAPK1Y185CRHY187SP1CYP11A1HSP90AA1IVLCRHR1NR4A1S301S412S386CRHTFAP2ACRHR1EPACCTNNB1KRT14Enzyme complexTranslocation DeubiquitinationActivationInhibitionAcetylationNegative regulation of gene expressionLEGENDLeads to through unknown mechanismPhosphorylationProtein-protein interactionTransportUbiquitinationDephosphorylationInduced catalysisAuto catalysisSumoylationPositive regulation of gene expressionReceptorLigandmRNAProteinProteinDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageRELAPRKCBPPRKCAPGNAQCREB1S133PRKAcAMPGNB5GNB3GNB2GNB1ADRBK2GNA11GNAO1GNASGNAI2GNAI1DAGIP3PIP2MAP2K1BRAFRAP1BPLCB3PLCG2S537PPLCG1PGSK3BS9PARP1PCCASP9PCCASP3PCCASP12PCMAPK8Y185T183MAP3K5PERNPCYP21A2CYP17A1STARCYP11B1CYP11A1CAMK2AHSD3B2GRK6ADRBK2ECE1NFKBIAPCGJA1CRHR2ARRB1SULT2A1ADRBK2CRHARRB2RELABCL2PI3KAKT1S473POMCNR4A2FOSCalciumPMCYARRB1ARRB2PMCYECE1CRHCRHR1CRHR2CRHCRHR1T399CRHCyclaseGNAZELK1TBX19FOSG-gammaInhibits Progesterone synthesis in Placental trophoblastspathwayDegradationand dissociationof NFKBsNFKB1NFKB1NFKB1MAPK14T180Y182NR4A1AP-1 complexClathrin and arrestin mediated endocytosisENPMPro-inflammatorycytokine productionCRHCRHBP


Description

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Comments

 
NetPath - Corticotropin-releasing hormone. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

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History

CompareRevisionActionTimeUserComment
53377view04:41, 6 November 2012NetPathDeleted pathway: wrong gpml
53376view04:21, 6 November 2012NetPathNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProduct31 (Entrez Gene)
ACTH production
ADRBK2GeneProduct157 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ARRB1GeneProduct408 (Entrez Gene)
ARRB2GeneProduct409 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CACNA1HGeneProduct8912 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
CASP12GeneProduct100506742 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CRHGeneProduct1392 (Entrez Gene)
CRHBPGeneProduct1393 (Entrez Gene)
CRHR1GeneProduct1394 (Entrez Gene)
CRHR2GeneProduct1395 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CYP11A1GeneProduct1583 (Entrez Gene)
CYP11A1GeneProduct
CYP11B1GeneProduct1584 (Entrez Gene)
CYP17A1GeneProduct1584 (Entrez Gene)
CYP21A2GeneProduct1589 (Entrez Gene)
CalciumMetabolite
DAGMetabolite
ECE1GeneProduct1889 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
EPACGeneProduct
ERNGeneProduct2081 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FOSBGeneProduct2354 (Entrez Gene)
FOSL1GeneProduct8061 (Entrez Gene)
FOSL2GeneProduct2355 (Entrez Gene)
G-gamma
GJA1GeneProduct2697 (Entrez Gene)
GNA11GeneProduct2767 (Entrez Gene)
GNAI1GeneProduct2770 (Entrez Gene)
GNAI2GeneProduct2771 (Entrez Gene)
GNAO1GeneProduct2775 (Entrez Gene)
GNAQGeneProduct2776 (Entrez Gene)
GNASGeneProduct2778 (Entrez Gene)
GNAZGeneProduct2781 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
GNB2GeneProduct2783 (Entrez Gene)
GNB3GeneProduct2784 (Entrez Gene)
GNB5GeneProduct10681 (Entrez Gene)
GRK6GeneProduct2870 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HSD3B1GeneProduct3283 (Entrez Gene)
HSD3B2GeneProduct3284 (Entrez Gene)
HSP90AA1GeneProduct3320 (Entrez Gene)
IL18GeneProduct3606 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL8GeneProduct
IP3Metabolite
IVLGeneProduct3713 (Entrez Gene)
JUNGeneProduct3726 (Entrez Gene)
JUNBGeneProduct3727 (Entrez Gene)
JUNDGeneProduct3728 (Entrez Gene)
KRT1GeneProduct3848 (Entrez Gene)
KRT14GeneProduct3861 (Entrez Gene)
LigandGeneProduct7040 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
NCOA2GeneProduct10499 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIAGeneProduct4792 (Entrez Gene)
NOS3GeneProduct4846 (Entrez Gene)
NR4A1GeneProduct3164 (Entrez Gene)
NR4A2GeneProduct4929 (Entrez Gene)
PARP1GeneProduct142 (Entrez Gene)
PI3K
PIP2Metabolite
PLCB3GeneProduct1394 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PLCG2GeneProduct5336 (Entrez Gene)
POMCGeneProduct5443 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRKAGeneProduct
PRKCAGeneProduct5578 (Entrez Gene)
PRKCBGeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
ProteinProtein
RAP1BGeneProduct5908 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
ReceptorGeneProduct7040 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
STARGeneProduct6770 (Entrez Gene)
SULT2A1GeneProduct6822 (Entrez Gene)
TBX19GeneProduct9095 (Entrez Gene)
TCF4GeneProduct6925 (Entrez Gene)
TFAP2AGeneProduct7020 (Entrez Gene)
TLR4GeneProduct7099 (Entrez Gene)
TRIM28GeneProduct10155 (Entrez Gene)
cAMPMetabolite
mRNAProtein

Annotated Interactions

No annotated interactions
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