Tryptophan metabolism (Rattus norvegicus)

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Quinolinate2-Formylaminobenzaldehyde5-Hydroxyindolepyruvate5-Methoxyindoleacetate7,8-DihydroxykynurenateGlycolysis / Gluconeogenesis4,8-Dihydroxyquinoline6-HydroxykynurenateNicotinate and nicotinamide metabolismN-MethyltryptamineOxaloacetate4-(2-Aminophenyl)-2,4-dioxobutanoateBenzoate degradation via hydroxylationN-Acetylindoxyl3-Hydroxy-L-kynurenine5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolin5-Hydroxykynurenamine5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate5-Hydroxy-N-formylkynurenineFormyl-5-hydroxykynurenamineAnthranilate2-AminomuconateC00527PhenylAla, Tyr and Trp biosynthesis5-(2'-Formylethyl)-4,6-dihydroxypicolinate5-Hydroxy-L-tryptophan4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoateKynurenate2-Formaminobenzoylacetate3-MethyldioxyindoleXanthurenicIndole-3-acetaldoxime5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate5-Hydroxyindoleacetylglycine3-MethylindolepyruvateCinnavalininate4,6-DihydroxyquinolineC01144Benzoate degradation via hydroxylation8-MethoxykynurenateGlucobrassicin3-Hydroxyanthranilate2-AminomuconateAnthranilate5-HydroxyindoleacetaldehydeN-MethylserotoninFormylanthranilateC003322-OxoglutarateIndole-3-acetaldehydeIndolelactate3-Hydroxykynurenamine3-MethoxyanthranilateIndole-3-acetateL-Tryptophanyl-tRNA5-Hydroxyindoleacetate4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate2-Amino-3-carboxymuconateIndolepyruvateMelatoninFormyl-N-acetyl-5-methoxykynurenamine2-Oxoadipate6-Hydroxyindolelactate7,8-Dihydro-7,8-dihydroxykynurenateIsophenoxazine3-(2-Aminoethyl)-1H-indol-5-olIndole-3-ethanol(Z)-5-Oxohex-2-enedioate2,3-Dihydroxyindole3-IndoleglycolaldehydeC00877Aldh1a11.13.11.-5-MethoxytryptamineCyp7b1Ido14.1.1.43Hadh1.13.11.17Ube3a1.1.1.110Hsd17b10Maob1.14.16.-Acmsd2-AminophenolCyp19a13.5.1.49Rnf254.2.1.84GcdhAcat1Inmt6-HydroxymelatoninIdo1Aldh3a2Ube3aDdc2.6.1.27IndoleAFMIDCyp2a2CYPC12Kynu1.7.3.2Rnf251.2.1.-1.13.99.3N-AcetylisatinCYP3A4Dhcr243.5.99.5Kynu1.14.13.9N-Acetylserotonin1.4.3.21.13.11.233.2.1.147Aldh2Tph1CatAldh1a4Echs1Cyp1b12.1.1.474.1.1.-1.5.1.-Aox1Aldh9a1Cyp2e11.14.16.3Ogdh1.10.3.4Mdm2Indole-3-acetamide1.13.12.3ALDH1A4Prmt1Cyp4f1GcdhKynuCyp2b15Aldh9a11.3.1.182.6.1.27Aldh3a2AanatTdo2CYP2A133.5.1.4Cyp1a2Acetyl-CoAAsmt3.5.1.9Prmt1MaobAadat1.14.99.2DdcL-TryptophanAadat1.2.3.7FormylkynurenineHaaoCyp2j4Cyp1a1Cyp2f4MaobWarsDd53.5.5.1Tryptamine3-IndoleacetonitrileAldh2Ido1Mdm22.1.1.49Cyp2c80Cyp2a1Asmt1.1.1.1905-HydroxykynurenineAldh1a11.13.11.10Aldh1a22.6.1.271.2.1.32Aldh1a21.1.1.191L-KynurenineMaobCyp2d24.1.99.1Mdm2DdcAbp1Prmt1


Description

No description

Comments

GenMAPP notes 
Converted from rat to human using ortholog information. Link to original KEGG map: http://www.genome.ad.jp/dbget-bin/show pathway?rno00380
GenMAPP remarks 
Edited by Sebastien Burel
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP465(r30270) with a 58% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
104907view19:17, 24 June 2019KhanspersModified description
104906view19:15, 24 June 2019Khanspersremoved genmapp comments
104823view12:58, 19 June 2019FehrhartModified description
74148view11:32, 1 April 2014EgonwReplaced an InChI with a more traditional identifier.
72159view12:14, 25 October 2013EgonwAdded a missing metabolite ID.
71802view20:34, 17 October 2013MaintBotAutomated update of data sources
69433view19:04, 8 July 2013MaintBotUpdated to 2013 gpml schema
67725view11:55, 26 June 2013DdiglesOntology Term : 'tryptophan metabolic pathway' added !
60278view22:09, 15 March 2013EgonwMore ChEBI / PubChem-compound identifiers.
60255view08:44, 15 March 2013EgonwMore ChEBI identifiers.
60235view22:09, 14 March 2013EgonwAdded ChEBI ids for three metabolites.
60234view22:04, 14 March 2013EgonwConverted many labels into Metabolite DataNode's.
53504view10:06, 8 November 2012Egonw
47755view04:47, 6 April 2012Khanspersupdated xrefs
41758view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34128view19:29, 9 December 2009MaintBotAutomatic update of empty xrefs
32379view16:54, 15 August 2009MaintBotFixed text labels
32020view13:23, 14 August 2009MaintBotFixed group labels
31416view20:56, 13 August 2009MaintBotFixed text labels
30955view00:44, 30 July 2009MaintBotConverted from Homo sapiens
21247view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Tryptophane Metabolism KEGG]] moved to [[Pathway:WP270]]: Moved to stable identifier
8468view13:46, 7 January 2008MaintBot[[Pathway:Rat:Tryptophane Metabolism KEGG]] moved to [[Pathway:Rattus norvegicus:Tryptophane Metabolism KEGG]]: Renaming species
7850view16:23, 18 December 2007MaintBotfixed category names
7409view12:42, 4 November 2007MaintBotAdded categories to GPML
6606view22:20, 22 May 2007L.M.Ferrantegpml file for [[Rat:Tryptophane_Metabolism_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1.1.1.110GeneProduct
1.1.1.190GeneProduct
1.1.1.191GeneProduct
1.10.3.4GeneProduct
1.13.11.-GeneProduct
1.13.11.10GeneProduct
1.13.11.17GeneProduct
1.13.11.23GeneProduct
1.13.12.3GeneProduct
1.13.99.3GeneProduct
1.14.13.9GeneProduct
1.14.16.-GeneProduct
1.14.16.3GeneProduct
1.14.99.2GeneProduct
1.2.1.-GeneProduct
1.2.1.32GeneProduct
1.2.3.7GeneProduct
1.3.1.18GeneProduct
1.4.3.2GeneProduct
1.5.1.-GeneProduct
1.7.3.2GeneProduct
2-AminophenolMetabolite2-Aminophenol
2.1.1.47GeneProduct
2.1.1.49GeneProduct
2.6.1.27GeneProduct
3-IndoleacetonitrileMetabolite3-Indoleacetonitrile
3.2.1.147GeneProduct
3.5.1.4GeneProduct
3.5.1.49GeneProduct
3.5.1.9GeneProduct
3.5.5.1GeneProduct
3.5.99.5GeneProduct
4.1.1.-GeneProduct
4.1.1.43GeneProduct
4.1.99.1GeneProduct
4.2.1.84GeneProduct
5-HydroxykynurenineMetabolite
5-MethoxytryptamineMetabolite
6-HydroxymelatoninMetabolite
AFMIDGeneProduct688283 (Entrez Gene)
ALDH1A4GeneProduct
AadatGeneProduct29416 (Entrez Gene)
AanatGeneProduct25120 (Entrez Gene)
Abp1GeneProduct65029 (Entrez Gene)
Acat1GeneProduct25014 (Entrez Gene)
Acetyl-CoAMetaboliteAcetyl-CoA
AcmsdGeneProduct171385 (Entrez Gene)
Aldh1a1GeneProduct24188 (Entrez Gene)
Aldh1a2GeneProduct116676 (Entrez Gene)
Aldh1a4GeneProduct
Aldh2GeneProduct29539 (Entrez Gene)
Aldh3a2GeneProduct65183 (Entrez Gene)
Aldh9a1GeneProduct64040 (Entrez Gene)
Aox1GeneProduct54349 (Entrez Gene)
AsmtGeneProduct246281 (Entrez Gene)
CYP2A13GeneProduct
CYP3A4GeneProduct
CYPC12GeneProduct
CatGeneProduct24248 (Entrez Gene)
Cyp19a1GeneProduct25147 (Entrez Gene)
Cyp1a1GeneProduct24296 (Entrez Gene)
Cyp1a2GeneProduct24297 (Entrez Gene)
Cyp1b1GeneProduct25426 (Entrez Gene)
Cyp2a1GeneProduct24894 (Entrez Gene)
Cyp2a2GeneProduct24895 (Entrez Gene)
Cyp2b15GeneProduct685222 (Entrez Gene)
Cyp2c80GeneProduct292330 (Entrez Gene)
Cyp2d2GeneProduct25053 (Entrez Gene)
Cyp2e1GeneProduct25086 (Entrez Gene)
Cyp2f4GeneProduct54246 (Entrez Gene)
Cyp2j4GeneProduct65210 (Entrez Gene)
Cyp4f1GeneProduct56266 (Entrez Gene)
Cyp7b1GeneProduct25429 (Entrez Gene)
Dd5GeneProduct117060 (Entrez Gene)
DdcGeneProduct24311 (Entrez Gene)
Dhcr24GeneProduct298298 (Entrez Gene) predicted
Echs1GeneProduct140547 (Entrez Gene)
FormylkynurenineMetaboliteFormylkynurenine
GcdhGeneProduct364975 (Entrez Gene) predicted
HaaoGeneProduct56823 (Entrez Gene)
HadhGeneProduct113965 (Entrez Gene)
Hsd17b10GeneProduct63864 (Entrez Gene)
Ido1GeneProduct66029 (Entrez Gene)
Indole-3-acetamideMetaboliteIndole-3-acetamide
IndoleMetabolite
InmtGeneProduct368066 (Entrez Gene)
KynuGeneProduct116682 (Entrez Gene)
L-KynurenineMetaboliteL-Kynurenine
L-TryptophanMetabolite
MaobGeneProduct25750 (Entrez Gene)
Mdm2GeneProduct314856 (Entrez Gene)
MelatoninMetaboliteInChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) (InChI)
N-AcetylisatinMetaboliteN-Acetylisatin
N-AcetylserotoninMetaboliteN-Acetylserotonin
OgdhGeneProduct360975 (Entrez Gene)
Prmt1GeneProduct60421 (Entrez Gene)
Rnf25GeneProduct301515 (Entrez Gene)
Tdo2GeneProduct64206 (Entrez Gene)
Tph1GeneProduct24848 (Entrez Gene)
TryptamineMetabolite
Ube3aGeneProduct361585 (Entrez Gene)
WarsGeneProduct314442 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP270"
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