Vitamin B2 (riboflavin) biosynthesis and conversion to FMN and FAD pathway (Zea mays)

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PlastidPeroxisome Mitochondria1CytosolVID-ribulose 5-phosphateH2OATP4.1.99.12GRMZM2G336908riboflavin transporterHCOOH2,5-diamino-6-ribosylamino-4(3H)-pyrmidinone 5' phosphate2.5.1.78VII2.5.1.9IVPO4H2ORiboflavin5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphatePyrPII1.1.1.193I3.5.4.26GTP3.5.4.25FMN3.1.3.-FAD3.6.1.182.7.7.22.7.1.26PPiATPADPAMPHCOOH, PPiNH3NAD(P)NAD(P)HH2OFMN3.1.3.2FAD3.6.1.182.7.7.22.7.1.26PPiATPADPAMPRiboflavinPO4riboflavin transporterH2OFMN3.1.3.2FAD3.6.1.182.7.7.22.7.1.26PPiATPADPAMPRiboflavinPO4FMNFADFMN transporterFAD transporterFMNFADGRMZM2G105466GRMZM2G156803GRMZM2G320099GRMZM2G090068GRMZM2G033219GRMZM2G143480GRMZM2G097820GRMZM2G009196GRMZM2G027115GRMZM2G135586GRMZM2G117609GRMZM2G028010GRMZM2G381933GRMZM2G149609GRMZM2G166931GRMZM5G819999GRMZM2G033634GRMZM5G819999GRMZM2G0336345-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione3,4-dihydroxybutanone 4-phosphate6,7-dimethyl-8-(D-ribityl)lumazineriboflavin transporterRiboflavinH2O


Description

Riboflavin is the precursor of the cofactors FMN and FAD, which are used by many oxidoreductases from the cytosol, plastids, mitochondria, and peroxisomes. In plants riboflavin synthesis takes place solely in plastids, from the precursors GTP and D-ribulose 5-phosphate. Riboflavin can be converted successively to FMN and FAD within plastids themselves, in the cytosol, or in mitochondria. There are also opposite pathways in which FAD and FMN are hydrolysed back to riboflavin. The details of the riboflavin, FAD, and FMN biosyntheses (especially their compartmentalization) in plants are far from being elucidated. This diagram is an attempt to capture the current state of the art

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Bibliography

  1. Gerdes S, Lerma-Ortiz C, Frelin O, Seaver SM, Henry CS, de Crécy-Lagard V, Hanson AD; ''Plant B Vitamin Pathways and their Compartmentation: a Guide for the Perplexed.''; J Exp Bot, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
110985view14:54, 25 June 2020L DupuisConnected lines
107278view14:37, 17 September 2019MaintBotChEBI identifier normalization
107037view13:49, 17 September 2019MaintBotHMDB identifier normalization
73527view23:38, 29 January 2014KhanspersModified title
72140view09:53, 25 October 2013Mkutmonannotated some metabolites
71953view23:13, 23 October 2013MaintBotremoved data source from nodes without identifier
70254view21:39, 15 July 2013MaintBotupdated to 2013 schema
65170view19:04, 5 June 2013MaintBotModified categories
55371view23:52, 13 December 2012SvetaGModified description
54083view00:16, 21 November 2012SvetaGModified description
54080view21:27, 20 November 2012SvetaGPeriodical save, work in progress
54079view21:17, 20 November 2012SvetaGPeriodical save, work in progress
54078view21:07, 20 November 2012SvetaGPeriodical save, work in progress
54077view20:53, 20 November 2012SvetaGPeriodical save, work in progress
54076view20:29, 20 November 2012SvetaGPeriodical save, work in progress
54075view20:19, 20 November 2012SvetaGPeriodical save, work in progress
53369view00:30, 6 November 2012PjaiswalModified title
52996view18:00, 25 October 2012PjaiswalModified title
52995view17:59, 25 October 2012PjaiswalModified title
52994view17:57, 25 October 2012PjaiswalModified categories
52993view17:57, 25 October 2012PjaiswalOntology Term : 'plant cell' added !
52992view17:56, 25 October 2012PjaiswalOntology Term : 'vitamin and vitamin metabolites signaling pathway' added !
52991view17:54, 25 October 2012PjaiswalNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1.1.1.193Protein1.1.1.193 (EC Number)
2,5-diamino-6-ribosylamino-4(3H)-pyrmidinone 5' phosphateMetabolite52402 (ChEBI)
2.5.1.78Protein2.5.1.78 (EC Number)
2.5.1.9Protein2.5.1.9 (EC Number)
2.7.1.26Protein2.7.1.26 (EC Number)
2.7.7.2Protein2.7.7.2 (EC Number)
3,4-dihydroxybutanone 4-phosphateMetabolite50606 (ChEBI)
3.1.3.-Protein3.1.3.- (EC Number)
3.1.3.2Protein3.1.3.2 (EC Number)
3.5.4.25Protein3.5.4.25 (EC Number)
3.5.4.26Protein3.5.4.26 (EC Number)
3.6.1.18Protein3.5.4.26 (EC Number)
4.1.99.12Protein4.1.99.12 (EC Number)
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphateMetabolite18337 (ChEBI)
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedioneMetabolite
5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphateMetabolite
6,7-dimethyl-8-(D-ribityl)lumazineMetabolite17601 (ChEBI)
ADPMetabolite
AMPMetabolite
ATPMetabolite
ATPMetaboliteATP
D-ribulose 5-phosphateMetabolite
FADMetabolite
FAD transporterProtein
FADMetabolite16238 (ChEBI)
FMN transporterProtein
FMNMetabolite17621 (ChEBI)
GRMZM2G009196GeneProductGRMZM2G009196 (Gramene Maize)
GRMZM2G027115GeneProductGRMZM2G027115 (Gramene Maize)
GRMZM2G028010GeneProductGRMZM2G028010 (Gramene Maize) Putative pseudogene
GRMZM2G033219GeneProductGRMZM2G033219 (Gramene Maize)
GRMZM2G033634GeneProductGRMZM2G033634 (Gramene Maize)
GRMZM2G090068GeneProductGRMZM2G090068 (Gramene Maize)
GRMZM2G097820GeneProductGRMZM2G097820 (Gramene Maize)
GRMZM2G105466GeneProductGRMZM2G105466 (Gramene Maize)
GRMZM2G117609GeneProductGRMZM2G117609 (Gramene Maize)
GRMZM2G135586GeneProductGRMZM2G135586 (Gramene Maize)
GRMZM2G143480GeneProductGRMZM2G143480 (Gramene Maize)
GRMZM2G149609GeneProductGRMZM2G149609 (Gramene Maize) Putative pseudogene
GRMZM2G156803GeneProductGRMZM2G156803 (Gramene Maize)
GRMZM2G166931GeneProductGRMZM2G166931 (Gramene Maize)
GRMZM2G320099GeneProductGRMZM2G320099 (Gramene Maize)
GRMZM2G336908GeneProductGRMZM2G336908 (Gramene Maize)
GRMZM2G381933GeneProductGRMZM2G381933 (Gramene Maize)
GRMZM5G819999GeneProductGRMZM5G819999 (Gramene Maize)
GTPMetabolite
H2OMetabolite
H2OMetaboliteH2O
HCOOHMetabolite
HCOOH, PPiMetabolite
IMetabolite
IIMetabolite
IVMetabolite
NAD(P)Metabolite
NAD(P)HMetabolite
NH3Metabolite
PO4Metabolite
PPiMetabolite
PyrPProtein
RiboflavinMetabolite17015 (ChEBI)
VIMetabolite
VIIMetabolite
riboflavin transporterProtein

Annotated Interactions

No annotated interactions

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