Oncostatin M Signaling Pathway (Homo sapiens)

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JUNDKRASGTPMAPK9MAPK8T183Y185MAP2K1S218LIFRPJAK2Y1007Y1007PRKCHPPRKCEPPRKCBPPRKCAPIL6STY759MAP2K2S226S222STAT3Y705STAT1Y701IL6STY782In astrocytes,adipose tissues,VSMCs, and inlung carcinomaSensitization of osteosarcoma cellsto apoptosisAdrenocortical Y-1 cells Mammary epithelial cells MEKdependentDissociationOncostatin M Signaling PathwayApoptosis in VEGFAJAK1HIF1AY1023Y1022MAPK14Y182Y180JAK3Y980TYK2Y1055Y1054RELAPMAPK3Y202Y204SOCS3OSMRY861PTPN11Y580Y542MAPK1Y185Y187STAT1Y701PIAS3STAT5BSTAT5BY699CASP3OSMSOS1GRB2SHC1PIRS1PSRCY419STAT3Y705S727RAF1S338HRASGTPPIK3R1AKT1S473T308OSMSTAT3Y705STAT1Y701FOSPXNPTK2BPCDK2CDKN1BCEBPBPRPS6S236S235JUNBPSTAT3PRKCDPMTORMMP13TP53STAT1STAT5BRICTORCREB1S133CYR61EGR1LDLREGR1CCL2MMP1MMP3NFKB1NFKBIAUbPRELANFKB1SERPINE1TIMP3CYNUCYNUCYNUCYNUCYNUCYNUCYNUIncrease in proliferationRegulation ofblood cholesterolIncrease in proliferationRegulation of osteoblastdifferentiationand activityCytoskeletonreorganizationSTAT5BY699STAT3Y705STAT1Y701MAPK3Y202Y204MAPK1Y185Y187Plaqueangiogenesis and destabilization incoronary arteryand arotic smoothmuscle cellsIn humanosteoblasts andU2OS cellsCartilagedegradationGrowthinhibitionin MCF-7cellsCASP7ProteinReceptorProteinProteinmRNALigandInduced activationEnzyme complexInhibitionTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation Induced catalysisProtein-protein interaction (PPI)LEGENDPhosphorylationNucleusCytoplasmCYNUActivationCASP9Dissociation of PPI


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History

CompareRevisionActionTimeUserComment
54192view13:25, 23 November 2012NetPathDeleted pathway: file not correct
54191view13:07, 23 November 2012NetPathNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1Protein207 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CASP7Protein840 (Entrez Gene)
CASP9Protein840 (Entrez Gene)
CCL2Rna6347 (Entrez Gene)
CDK2Protein1017 (Entrez Gene)
CDKN1BProtein1027 (Entrez Gene)
CEBPBProtein1051 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CYR61Rna3491 (Entrez Gene)
EGR1Rna1958 (Entrez Gene)
FOSProtein2353 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
HIF1ARna
HRASProtein3265 (Entrez Gene)
IL6STProtein3572 (Entrez Gene)
IRS1Protein3667 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JAK3Protein3718 (Entrez Gene)
JUNBProtein3726 (Entrez Gene)
JUNDProtein3727 (Entrez Gene)
KRASProtein3845 (Entrez Gene)
LDLRRna3949 (Entrez Gene)
LIFRProtein3977 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP13Rna4322 (Entrez Gene)
MMP1Rna4312 (Entrez Gene)
MMP3Rna4314 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
OSMProtein5008 (Entrez Gene)
OSMRProtein9180 (Entrez Gene)
PIAS3Protein10401 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCBProtein5579 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PRKCEProtein5581 (Entrez Gene)
PRKCHProtein5583 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PXNProtein5829 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RICTORProtein253260 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
SERPINE1Rna5054 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SOCS3Protein9021 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
TIMP3Rna7078 (Entrez Gene)
TP53Rna7157 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
VEGFARna

Annotated Interactions

No annotated interactions

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