Brain-derived neurotrophic factor (BDNF) signaling (Homo sapiens)

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VAV3MAPK9PCDK5R1SHC2MAPK8PMAPK3T202Y204γ-secretasecomplexCa2+ELMOOxidativeneuronalnecrosismembraneboundEndocytosis-dependentBrain-derived neurotrophic factor signaling pathwayDegradationSelectivepostsynapticdevelopmentNeuriteoutgrowthReduction inphosphorylationLamellipodia formationand increasedneurite outgrowthSynaptic plasticityDissociationProteinsynthesisBCL2L11CYFIP1NCK1NCK2SHC1PPLCG1Y783PTPN11PCDH2TRAF6CTNNB1Y654SQSTM1FYNY420SHC3PNGFRNCAM1Y734TIAM1Y829LINGO1RANBP9DOK5PSHC4PGRB2SIRPAPKCNA3PFRS2PGRIN2BPFRS3PDOCK3PNTRK1PRAC1CDKL5PSORT1NGFBDNFGRIA2CREB1S133NSFGNB2L1GABRB3S432S433PPP2CACRTC1KSR1MAP2K2PMAPK1T185Y187MAP2K1PSH2B2PFOXO3T32S253MTORS2448KIDINS220PRPS6KB1T444S447T412EIF4EBP1T46T37AKT1S473T308BADS99S75SH2BPGSK3BS9GRIN1PIRS2PMAPK7Y221T219IRS1PTSC2T1462GRIA1PCAMK4PCAMK2PEEF2ACACBS78PRKAA2T172MAPTS195S198S202ELK1PIGF2BP1Y396PTK2BY402RAF1S338VAV2Y172CDK5Y15NFATC4NCF2NCF1NFATC4CYNUCYNUSTAT5BCDC42CNR1NTRK3PIK3R1NTF3BDNFPDPK1S241MAP3K1ADAM17MAPK10PHRASGTPRPS6S236S244S240S235EIF4EPPIK3R2IP3SRCFOXO3PIP2DAGSTAT5ANFKB1RELAS529NFKB1IKKRELAS529NFKBIAS36S32JUNPCASP3ProteinReceptorProteinProteinmRNASmall moleculeLigandInduced activationEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationPTM stateProtein-protein interactionDephosphorylationLEGENDPhosphorylationNucleusCytoplasmPlasma membraneCYPMNUProteolytic cleavageMoleculeCalcificationNeuronal growth,differentiation,and protectionInhibition ofapoptosisNitric oxideproductionApoptosisInhibition ofapoptosisRPS6KA3S227S386YBX1S102RPS6KA1S221S380RPS6KA5PCAMK1T177MAPK14Y182T180RASGRF1DPYSL2T514APCPTPRFDLG1GRIP1GRIA3RHOGPAKKCNN2PCFL1PBDNFBDNFPIP2PIP3PIK3CACalmodulinSOSCAMKKCalcineurinPRKAA1T196EnhancedfatoxidationReduction in FOXO3 shuttleto nucleus anddecrease in BIMMAP2K5MAP3K2MEF2CMEF2ACerebellargranuleneuronalsurvivalCYNURAP1AMAPK7Y221T219CYNURegulation of surface expression of AMPA receptorsPKCRegulation ofsynaptic plasticitySTAT5BSTAT5AGrowthconemotilityCYNURegulation of Pre-synapticplasticity CYNUCYNUHuman airwaysmooth muscle cellproliferationRelease of RNG105from RNA granulesJAK2PSTAT1PSTAT3PMajor pelvicganglia neuriteoutgrowthCEBPBFOSEGR1EGR2Cortical dendrite differentiationMARCKSPPRKCDY311CDK5dependentregulation of CDC42activityRadial migrationof corticalneuronsNTRK2S495Y722NTRK2K811Y723In secretorygranulesROSGSK3BS9MicrotubuleassemblyCSNK2A1RAB3AGTPcAMPPKASPP1ALPLBMP2EIF2S1EIF2S2MAPK3Y204T202MAPK1Y187T185SYN1PNeurotransmitterreleasemembranebound


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History

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CompareRevisionActionTimeUserComment
129694view00:49, 22 May 2024EweitzModified title
126377view17:55, 25 April 2023EgonwLicense is CCZero (more specific)
120727view01:41, 24 December 2021EweitzStandardize font, weight, case
116399view00:01, 7 May 2021EweitzModified title
106345view21:34, 21 August 2019KhanspersModified description
106165view12:06, 16 August 2019MaintBotHMDB identifier normalization
105546view06:09, 9 August 2019KhanspersModified description
94178view13:37, 25 August 2017Mkutmonadded missing metabolite identifiers
89803view11:37, 6 October 2016Mkutmonfixed special characters in description
87427view11:51, 22 July 2016MkutmonModified description
86036view12:36, 28 June 2016EveloModified title
79953view11:49, 28 April 2015ZariAnnotated IP3 and IKK
79265view20:25, 19 March 2015ZariChenged Identifier for NFC1
71549view19:25, 17 October 2013MaintBotremoved data source from nodes without identifier
71001view15:55, 22 September 2013EgonwAdded three metabolite IDs.
67076view10:03, 26 June 2013Christine ChichesterOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
61289view21:55, 6 April 2013MaintBotremoved old publication references
61232view17:23, 5 April 2013MaintBotupdated pathway elements from provided gpml
61042view04:48, 3 April 2013NetPathModified description
60957view10:30, 1 April 2013NetPathPeriodical save, work in progress
54595view18:45, 4 December 2012MaintBotModified categories
54573view07:11, 4 December 2012NetPathModified description
54552view13:14, 3 December 2012NetPathNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACBProtein32 (Entrez Gene)
ADAM17Protein6868 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
ALPLRna249 (Entrez Gene)
APCProtein324 (Entrez Gene)
BADProtein572 (Entrez Gene)
BCL2L11Rna10018 (Entrez Gene)
BDNFProtein627 (Entrez Gene)
BMP2Rna650 (Entrez Gene)
CAMK1Protein8536 (Entrez Gene)
CAMK2Protein815 (Entrez Gene)
CAMK4Protein814 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CDC42Protein998 (Entrez Gene)
CDH2Protein1000 (Entrez Gene)
CDK5Protein1020 (Entrez Gene)
CDK5R1Protein8851 (Entrez Gene)
CDKL5Protein6792 (Entrez Gene)
CEBPBProtein1385 (Entrez Gene)
CFL1Protein1072 (Entrez Gene)
CNR1Protein1268 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CRTC1Protein23373 (Entrez Gene)
CSNK2A1Protein1457 (Entrez Gene)
CTNNB1Protein1499 (Entrez Gene)
CYFIP1GeneProduct23191 (Entrez Gene)
DAGMetabolite
DLG1Protein1739 (Entrez Gene)
DOCK3Protein1795 (Entrez Gene)
DOK5Protein55816 (Entrez Gene)
DPYSL2Protein1808 (Entrez Gene)
EEF2Protein1938 (Entrez Gene)
EGR1Rna1958 (Entrez Gene)
EGR2Rna1959 (Entrez Gene)
EIF2S1Protein1965 (Entrez Gene)
EIF2S2Protein8894 (Entrez Gene)
EIF4EProtein1977 (Entrez Gene)
EIF4EBP1Protein1978 (Entrez Gene)
ELK1Protein2002 (Entrez Gene)
FOSRna2353 (Entrez Gene)
FOXO3Protein2309 (Entrez Gene)
FRS2Protein10818 (Entrez Gene)
FRS3Protein10817 (Entrez Gene)
FYNProtein2534 (Entrez Gene)
GABRB3Protein2562 (Entrez Gene)
GNB2L1Protein10399 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
GRIA1Protein2890 (Entrez Gene)
GRIA2Protein2891 (Entrez Gene)
GRIA3Protein2892 (Entrez Gene)
GRIN1Protein2902 (Entrez Gene)
GRIN2BProtein2904 (Entrez Gene)
GRIP1Protein23426 (Entrez Gene)
GSK3BProtein2932 (Entrez Gene)
HRASProtein3265 (Entrez Gene)
IGF2BP1Protein10642 (Entrez Gene)
IKKProtein
IP3Protein
IRS1Protein3667 (Entrez Gene)
IRS2Protein8660 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
KCNA3Protein3738 (Entrez Gene)
KCNN2Protein3781 (Entrez Gene)
KIDINS220Protein57498 (Entrez Gene)
KSR1Protein8844 (Entrez Gene)
LINGO1Protein84894 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAP2K5Protein5607 (Entrez Gene)
MAP3K1Protein4214 (Entrez Gene)
MAP3K2Protein10746 (Entrez Gene)
MAPK10Protein5602 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK7Protein5598 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MAPTProtein4137 (Entrez Gene)
MARCKSProtein4082 (Entrez Gene)
MEF2AProtein4205 (Entrez Gene)
MEF2CProtein4208 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
NCAM1Protein4684 (Entrez Gene)
NCF1Protein4687 (Entrez Gene)
NCF2Protein4688 (Entrez Gene)
NCK1Protein4690 (Entrez Gene)
NCK2Protein8440 (Entrez Gene)
NFATC4Protein4776 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
NGFProtein4803 (Entrez Gene)
NGFRProtein4804 (Entrez Gene)
NSFProtein4905 (Entrez Gene)
NTF3Protein4908 (Entrez Gene)
NTRK1Protein4914 (Entrez Gene)
NTRK2Protein4915 (Entrez Gene)
NTRK3Protein4916 (Entrez Gene)
PDPK1Protein5170 (Entrez Gene)
PIK3CAProtein5296 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PIP2Metabolite
PIP3Metabolite
PLCG1Protein5335 (Entrez Gene)
PPP2CAProtein5515 (Entrez Gene)
PRKAA1Protein5562 (Entrez Gene)
PRKAA2Protein5563 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PTPRFProtein5792 (Entrez Gene)
RAB3AProtein5864 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RANBP9Protein10048 (Entrez Gene)
RAP1AProtein5906 (Entrez Gene)
RASGRF1Protein5923 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RHOGProtein391 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KA1Protein6195 (Entrez Gene)
RPS6KA3Protein6197 (Entrez Gene)
RPS6KA5Protein9252 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
SH2B2Protein10603 (Entrez Gene)
SH2BProtein25970 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SHC2Protein25759 (Entrez Gene)
SHC3Protein53358 (Entrez Gene)
SHC4Protein399694 (Entrez Gene)
SIRPAProtein140885 (Entrez Gene)
SORT1Protein6272 (Entrez Gene)
SPP1Rna6696 (Entrez Gene)
SQSTM1Protein8878 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
SYN1Protein6853 (Entrez Gene)
TIAM1Protein7074 (Entrez Gene)
TRAF6Protein7189 (Entrez Gene)
TSC2Protein7249 (Entrez Gene)
VAV2Protein7410 (Entrez Gene)
VAV3Protein10451 (Entrez Gene)
YBX1Protein4904 (Entrez Gene)
cAMPMetabolite

Annotated Interactions

No annotated interactions

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