Quercetin and Nf-kB/ AP-1 induced cell apoptosis-delete (Homo sapiens)

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2, 355E-boxPhosphorylated4AP-1 transcription factor complexIKBKBQuercetinNFKB1Arachidonic acidIKBA_HUMANProstaglandin H2Prostaglandin G2ACOX2FOSPhosphorylatedIKBA_HUMANNf-kBNOS1VEGFAAngiogenesisCARCINOGENESISNFKB1JUNAP-1MMP1METASTASISGene boxE-boxGene box77757755AREROSApoptosisinduces malformation57inhibits dimerizationinhibition of ubiquitination587DNA damageCYP2A6carcinogenic metaboliteNFE2L2KEAP1NFE2L2NFE2L2small MAFPhase 2 enzymeCell cycle arrest5Malignancy(Causes vasodilation;inhibits platelet aggregation)562, 32, 322, 3222, 4Phospholipase A2 (PLA2)Cox1/Cox2Prostaglandin I2Thromboxane A2(Causes vasoconstriction;promotes platelet aggregation)Cell membrane phospholipids(Increasesvasoconstriction)Prostaglandin F2aProstaglandin D2Prostaglandin E2(Induces vasoconstriction and secretion of IL-1 and IL-2)INFLAMMATION444444444442


Description

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Bibliography


History

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CompareRevisionActionTimeUserComment
59128view22:32, 21 February 2013MaintBotDeleted pathway: tutorial
57890view19:40, 4 February 2013MaintBotModified title
56310view19:45, 5 January 2013BeanthaPeriodical save, work in progress
56309view18:26, 5 January 2013BeanthaPeriodical save, work in progress
56306view18:00, 5 January 2013Beanthaquercetin zonder inflammation
56305view17:57, 5 January 2013BeanthaPeriodical save, work in progress
56304view17:47, 5 January 2013BeanthaPeriodical save, work in progress
56301view17:37, 5 January 2013BeanthaPeriodical save, work in progress
56296view16:20, 5 January 2013BeanthaQuercetin pathway
56294view16:16, 5 January 2013BeanthaPeriodical save, work in progress
56290view16:06, 5 January 2013BeanthaPeriodical save, work in progress
56288view15:55, 5 January 2013BeanthaPeriodical save, work in progress
56282view15:45, 5 January 2013BeanthaPeriodical save, work in progress
56279view15:35, 5 January 2013BeanthaPeriodical save, work in progress
56276view15:24, 5 January 2013BeanthaPeriodical save, work in progress
55527view14:29, 17 December 2012Cboye21fina final�pathway
55526view14:23, 17 December 2012Cboye21Periodical save, work in progress
55523view14:13, 17 December 2012Cboye21Periodical save, work in progress
55517view14:03, 17 December 2012Cboye21Periodical save, work in progress
55516view13:52, 17 December 2012Cboye21final version
55515view13:31, 17 December 2012Cboye21Periodical save, work in progress
55351view17:11, 13 December 2012Cboye21final pathway
55350view17:07, 13 December 2012Cboye21Periodical save, work in progress
55347view16:47, 13 December 2012Cboye21Periodical save, work in progress
55346view16:46, 13 December 2012Cboye21Almost finalized
55344view16:27, 13 December 2012Cboye21Periodical save, work in progress
55339view16:18, 13 December 2012Cboye21All pathways included
55337view16:15, 13 December 2012Cboye21extra pathway
55327view15:49, 13 December 2012Cboye21Periodical save, work in progress
55317view15:29, 13 December 2012Cboye21Periodical save, work in progress
55312view15:19, 13 December 2012Cboye21Periodical save, work in progress
55305view15:09, 13 December 2012Cboye21Periodical save, work in progress
55296view14:59, 13 December 2012Cboye21Periodical save, work in progress
55291view14:48, 13 December 2012Cboye21Periodical save, work in progress
55283view14:38, 13 December 2012Cboye21Periodical save, work in progress
55267view14:18, 13 December 2012Cboye21Periodical save, work in progress
55262view14:08, 13 December 2012Cboye21Periodical save, work in progress
55255view13:57, 13 December 2012Cboye21New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(Causes vasoconstriction; promotes platelet aggregation)
(Causes vasodilation; inhibits platelet aggregation)
(Increases vasoconstriction)
(Induces vasoconstriction and secretion of IL-1 and IL-2)
ACOX2GeneProductENSG00000168306 (Ensembl Human)
AngiogenesisPathway
Arachidonic acidMetaboliteHMDB01043 (HMDB)
CARCINOGENESIS Pathway
CYP2A6GeneProductENSG00000255974 (Ensembl Human) one of several possible phase 1 enzymes
Cell membrane phospholipids
DNA damage
FOSGeneProductENSG00000170345 (Ensembl Human)
IKBA_HUMANProteinP25963 (Uniprot/TrEMBL)
IKBKBGeneProductENSG00000104365 (Ensembl Human)
INFLAMMATION
JUNGeneProductENSG00000177606 (Ensembl Human)
KEAP1GeneProductENSG00000079999 (Ensembl Human)
METASTASIS Pathway
MMP1GeneProductENSG00000196611 (Ensembl Human)
NFE2L2GeneProductENSG00000116044 (Ensembl Human)
NFKB1GeneProductENSG00000109320 (Ensembl Human)
NOS1GeneProductENSG00000089250 (Ensembl Human)
Phase 2 enzyme Protein
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin E2MetaboliteHMDB01220 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin G2MetaboliteHMDB03235 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
QuercetinMetaboliteHMDB05794 (HMDB)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
VEGFAGeneProductENSG00000112715 (Ensembl Human)
carcinogenic metaboliteMetabolite
small MAFProtein

Annotated Interactions

No annotated interactions

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