Angiogenesis overview (Homo sapiens)

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Ca2+ releaseCa2+survivaleloClamellopodia and filopodiaGFStem CellTKIntegrinsangiogenesisMT-MMPmigrationbreakdown of extracellulartissue like collagenROSmigrationsurvivalProteosomemigrationproliferationpermeabilitytranscription of angiogenesis-related genesROBO1DOK2AKT1NADPH oxidase 2RAF1MAP3K7MAP2K1MAP2K1PLXND1NOX4Dia1FAKPIK3CDPLCG1OHNOATF2ELK1IP3FGF1PRKCASHC1ANGPT1SOS1MMP9PTPN11SLIT2MMP2SRCCRKTIMP4PI3KMMP14MAPK11PIP3PAK1WASPIP2HIF2-alphaROBO4RAF1PLDPIP2NOS3TEKKDRPDPK1MMP12TIMP2MAP2K6Ras SHBCRKIQGAP1PHDFRS2ERK 1/2 MAPKPIP2ROBO1PLA2G1BCDC42GRB14AKT1MAPK1NRP1MTORRas GAPDAG1STAT5FAKPRKCAMAPK8BADMMPsGRB2BMXSEMA3AThrombinNCK1GRB2APCCDC42RASSEMA4APLC-gammaRAC1urokinase-plasminogen activatorhypoxiaMAPK14PTPN11ROBO4RasVEGFADAG1PXNVHLFGFR1MAP2K4STAT3HIF2-alphaHIF2-alphaOHpUbeloBGRB2SOS1GRB7SLIT2Stem CellStem Celllamellopodia and filopodiaSLIT2


Description

Overview of processes involved in the development of angiogenesis in humans.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
126081view09:00, 1 April 2023EgonwRemoved unclear "GF" comment
126080view08:50, 1 April 2023EgonwAdded a few datanode types (guessed a few, because no IDs were given)
110975view14:21, 25 June 2020L DupuisConnected lines
106214view12:11, 16 August 2019MaintBotHMDB identifier normalization
85555view08:32, 29 May 2016EgonwReplaced a mim-conversion with Arrow.
71385view18:41, 17 October 2013MaintBotAutomated update of data sources
71268view21:58, 16 October 2013MaintBotAutomated update of data sources
69001view17:45, 8 July 2013MaintBotUpdated to 2013 gpml schema
59192view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
58505view19:00, 14 February 2013MaintBotModified title
44954view12:37, 6 October 2011MartijnVanIerselOntology Term : 'growth factor signaling pathway' added !
44820view13:30, 5 October 2011SusanModified description
44464view18:42, 14 September 2011MaintBotModified categories
44462view14:33, 14 September 2011Helixangiogenesis overview
44393view10:35, 8 September 2011Helixangiogenesis overviuew
44392view10:26, 8 September 2011HelixPeriodical save, work in progress
44389view10:15, 8 September 2011HelixPeriodical save, work in progress
43912view12:37, 16 August 2011Helixangiogensisi overview
43911view12:29, 16 August 2011HelixPeriodical save, work in progress
43909view12:19, 16 August 2011HelixPeriodical save, work in progress
43908view11:54, 16 August 2011HelixPeriodical save, work in progress
43907view11:43, 16 August 2011HelixPeriodical save, work in progress
43906view11:31, 16 August 2011Helixangiogenesis overview
43905view11:11, 16 August 2011HelixPeriodical save, work in progress
43902view11:48, 15 August 2011Helixangiogenesis overview
43901view11:46, 15 August 2011HelixPeriodical save, work in progress
43900view11:36, 15 August 2011HelixPeriodical save, work in progress
43899view11:26, 15 August 2011HelixPeriodical save, work in progress
43898view11:15, 15 August 2011HelixPeriodical save, work in progress
43896view11:04, 15 August 2011Helixangiogenesis overview
43605view09:00, 7 July 2011Helixangiopgenesis overview
43604view08:57, 7 July 2011HelixPeriodical save, work in progress
43603view08:46, 7 July 2011HelixPeriodical save, work in progress
43602view08:36, 7 July 2011HelixPeriodical save, work in progress
43596view09:28, 6 July 2011Helixangiogenesis overview
43146view13:05, 3 June 2011Helixangiogenesis overview
43145view12:58, 3 June 2011HelixPeriodical save, work in progress
43144view12:48, 3 June 2011HelixPeriodical save, work in progress
43143view12:37, 3 June 2011HelixPeriodical save, work in progress
43142view12:27, 3 June 2011HelixPeriodical save, work in progress
43141view12:17, 3 June 2011HelixPeriodical save, work in progress
43140view11:38, 3 June 2011HelixPeriodical save, work in progress
43139view11:28, 3 June 2011HelixPeriodical save, work in progress
43138view11:17, 3 June 2011HelixPeriodical save, work in progress
43137view11:07, 3 June 2011HelixPeriodical save, work in progress
43136view10:43, 3 June 2011HelixPeriodical save, work in progress
43135view10:40, 3 June 2011Helixangiogenesis overview
43134view10:33, 3 June 2011HelixPeriodical save, work in progress
43133view10:23, 3 June 2011HelixPeriodical save, work in progress
43132view10:13, 3 June 2011HelixPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl Human)
ANGPT1GeneProductENSG00000154188 (Ensembl Human)
APCGeneProductENSG00000134982 (Ensembl Human)
ATF2GeneProductENSG00000115966 (Ensembl Human)
BADGeneProductENSG00000002330 (Ensembl Human)
BMXGeneProductENSG00000102010 (Ensembl Human)
CDC42GeneProductENSG00000070831 (Ensembl Human)
CRKGeneProductENSG00000167193 (Ensembl Human)
DAG1GeneProductENSG00000173402 (Ensembl Human)
DOK2GeneProductENSG00000147443 (Ensembl Human)
Dia1ProteinNP_031884.1 (RefSeq)
ELK1GeneProductENSG00000126767 (Ensembl Human)
ERK 1/2 MAPKProtein
FAKProtein
FAKProteinQ14289 (Uniprot/TrEMBL)
FGF1GeneProductENSG00000113578 (Ensembl Human)
FGFR1GeneProductENSG00000077782 (Ensembl Human)
FRS2GeneProductENSG00000166225 (Ensembl Human)
GRB14GeneProductENSG00000115290 (Ensembl Human)
GRB2GeneProductENSG00000177885 (Ensembl Human)
GRB7GeneProductENSG00000141738 (Ensembl Human)
HIF2-alphaProtein
IP2Protein
IP3
IQGAP1GeneProductENSG00000140575 (Ensembl Human)
KDRGeneProductENSG00000128052 (Ensembl Human)
MAP2K1GeneProductENSG00000169032 (Ensembl Human)
MAP2K4GeneProductENSG00000065559 (Ensembl Human)
MAP2K6GeneProductENSG00000108984 (Ensembl Human)
MAP3K7GeneProductENSG00000135341 (Ensembl Human)
MAPK11GeneProductENSG00000185386 (Ensembl Human)
MAPK14GeneProductENSG00000112062 (Ensembl Human) p38 MAPK
MAPK1GeneProductENSG00000100030 (Ensembl Human)
MAPK8GeneProductENSG00000107643 (Ensembl Human)
MMP12Protein
MMP14GeneProductENSG00000157227 (Ensembl Human)
MMP2GeneProductENSG00000087245 (Ensembl Human)
MMP9GeneProductENSG00000100985 (Ensembl Human)
MMPsGeneProductENSG00000087245 (Ensembl Human)
MTORGeneProductENSG00000198793 (Ensembl Human)
NADPH oxidase 2Protein
NCK1GeneProductENSG00000158092 (Ensembl Human)
NO
NOS3GeneProductENSG00000164867 (Ensembl Human)
NOX4GeneProductENSG00000086991 (Ensembl Human)
NRP1GeneProductENSG00000099250 (Ensembl Human)
OH
PAK1GeneProduct5058 (Entrez Gene)
PDPK1GeneProductENSG00000140992 (Ensembl Human)
PHDProtein
PI3KProtein
PIK3CDGeneProductENSG00000171608 (Ensembl Human)
PIP2Protein
PIP2MetaboliteHMDB10032 (HMDB)
PIP3Protein
PLA2G1BGeneProductENSG00000170890 (Ensembl Human)
PLC-gammaGeneProductENSG00000124181 (Ensembl Human)
PLCG1GeneProductENSG00000124181 (Ensembl Human)
PLDProtein
PLXND1GeneProductENSG00000004399 (Ensembl Human)
PRKCAGeneProductENSG00000154229 (Ensembl Human)
PTPN11GeneProductENSG00000179295 (Ensembl Human)
PXNGeneProductENSG00000089159 (Ensembl Human)
RAC1GeneProductENSG00000136238 (Ensembl Human)
RAF1GeneProductENSG00000132155 (Ensembl Human)
RASGeneProductENSG00000133703 (Ensembl Human)
ROBO1GeneProductENSG00000169855 (Ensembl Human)
ROBO4GeneProductENSG00000154133 (Ensembl Human)
RasProtein
Ras ProteinENSG00000133703 (Ensembl Human)
Ras GAPProtein
SEMA3AGeneProductENSG00000075213 (Ensembl Human)
SEMA4AGeneProductENSG00000196189 (Ensembl Human)
SHBGeneProductENSG00000107338 (Ensembl Human)
SHC1GeneProductENSG00000160691 (Ensembl Human)
SLIT2GeneProductENSG00000145147 (Ensembl Human)
SOS1GeneProductENSG00000115904 (Ensembl Human)
SRCGeneProductENSG00000197122 (Ensembl Human)
STAT3Protein
STAT5Protein
TEKGeneProductENSG00000120156 (Ensembl Human)
TIMP2GeneProductENSG00000035862 (Ensembl Human)
TIMP4GeneProductENSG00000157150 (Ensembl Human)
ThrombinProtein176930 (OMIM)
VEGFAGeneProductENSG00000112715 (Ensembl Human)
VHLGeneProductENSG00000134086 (Ensembl Human)
WASPProteinP42768 (Uniprot/TrEMBL)
hypoxia
pUb
urokinase-plasminogen activatorProtein

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1993"
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