Oxidation by cytochrome P450 (Mus musculus)
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Cytochrome P450 genes
Cyb5r3
Cyp27a1
Cyp2e1
CYP4A11
Fe3+
CYP4Z1
Cyp2s1
Substrate
Fe2+
Cyp2f2
Cyb5b
CYP4F8
Cyp1b1
Cyb5
Cyp17a1
Cyp19a1
Cyb5
NAD+
Cyp4v3
CYP4F11
Fe2+
Cyp4f39
NADH
Cyp4b1
Fe3+
Substrate
CYP3A43
Cyp4f18
Water
Substrate
CYP2C8
CYP2A7
CYP2B6
Cyb5r1
Cyp11b1
Cyp1a2
O2
Cyp4x1
Cyp7b1
Cyp8b1
CYP2J2
Fe3+
CYP2C19
CYP
CYP
CYP4F12
Fe2+
CYP27C1
CYP2D6
Cyb5
CYP4F2
Cyp51
CYP2C9
Cyb5r2
Cyp7a1
Cyb5b
Cyp26b1
CYP2C18
CYP2A13
NADPH
Cyp2u1
Cyp39a1
Cyb5b
CYP
Cyp27b1
Cyp2r1
Cyp21a1
CYP3A4
CYP3A5
Cyp26c1
Cyp46a1
NADP+
Por
Cyp51
CYP4A22
Substrate
Substrate-OH
Substrate
Cyb5r4
AC161058.2-1
CYP
CYP2G1P
Cyp11b2
activated O2
Cyp1a1
Cyp24a1
Cyp26a1
O2
Fe2+
Cyp11a1
CYP3A7
CYP2A6
Fe3+
Cyp20a1
CYP
Description
Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP43(r29608)
with a 53% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996
History
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Comment
125273
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16:01, 31 January 2023
Larsgw
Add ISBN to publication
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06:28, 11 December 2022
AlexanderPico
fixed citations
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10:42, 23 May 2021
Eweitz
Modified title
107196
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14:28, 17 September 2019
MaintBot
ChEBI identifier normalization
106852
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13:33, 17 September 2019
MaintBot
HMDB identifier normalization
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23:10, 29 January 2014
Khanspers
Modified title
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view
18:24, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67126
view
10:10, 26 June 2013
Christine Chichester
Ontology Term : 'phase I biotransformation pathway via cytochrome P450' added !
59077
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21:45, 21 February 2013
MaintBot
Updated Ensembl and UniProt data source
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19:12, 14 February 2013
MaintBot
Modified title
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05:32, 17 May 2012
MaintBot
Automatic update of PubChem xrefs
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22:36, 24 April 2011
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22:23, 24 April 2011
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00:30, 2 March 2011
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Removed redundant pathway information and comments
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18:04, 10 December 2009
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Automatic update of empty xrefs
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20:49, 14 September 2009
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added xrefs
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view
12:39, 14 August 2009
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Fixed group labels
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00:27, 30 July 2009
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New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
AC161058.2-1
GeneProduct
ENSMUSG00000029541 (Ensembl Mouse)
CYP
GeneProduct
CYP27C1
GeneProduct
CYP2A13
GeneProduct
CYP2A6
GeneProduct
CYP2A7
GeneProduct
CYP2B6
GeneProduct
CYP2C18
GeneProduct
CYP2C19
GeneProduct
CYP2C8
GeneProduct
CYP2C9
GeneProduct
CYP2D6
GeneProduct
CYP2G1P
GeneProduct
CYP2J2
GeneProduct
CYP3A4
GeneProduct
CYP3A43
GeneProduct
CYP3A5
GeneProduct
CYP3A7
GeneProduct
CYP4A11
GeneProduct
CYP4A22
GeneProduct
CYP4F11
GeneProduct
CYP4F12
GeneProduct
CYP4F2
GeneProduct
CYP4F8
GeneProduct
CYP4Z1
GeneProduct
Cyb5
GeneProduct
ENSMUSG00000024646 (Ensembl Mouse)
Cyb5b
GeneProduct
ENSMUSG00000031924 (Ensembl Mouse)
Cyb5r1
GeneProduct
ENSMUSG00000026456 (Ensembl Mouse)
Cyb5r2
GeneProduct
ENSMUSG00000048065 (Ensembl Mouse)
Cyb5r3
GeneProduct
ENSMUSG00000018042 (Ensembl Mouse)
Cyb5r4
GeneProduct
ENSMUSG00000032872 (Ensembl Mouse)
Cyp11a1
GeneProduct
ENSMUSG00000032323 (Ensembl Mouse)
Cyp11b1
GeneProduct
110115 (Entrez Gene)
Cyp11b2
GeneProduct
13072 (Entrez Gene)
Cyp17a1
GeneProduct
ENSMUSG00000003555 (Ensembl Mouse)
Cyp19a1
GeneProduct
ENSMUSG00000032274 (Ensembl Mouse)
Cyp1a1
GeneProduct
ENSMUSG00000032315 (Ensembl Mouse)
Cyp1a2
GeneProduct
ENSMUSG00000032310 (Ensembl Mouse)
Cyp1b1
GeneProduct
ENSMUSG00000024087 (Ensembl Mouse)
Cyp20a1
GeneProduct
ENSMUSG00000049439 (Ensembl Mouse)
Cyp21a1
GeneProduct
ENSMUSG00000024365 (Ensembl Mouse)
Cyp24a1
GeneProduct
ENSMUSG00000038567 (Ensembl Mouse)
Cyp26a1
GeneProduct
ENSMUSG00000024987 (Ensembl Mouse)
Cyp26b1
GeneProduct
ENSMUSG00000063415 (Ensembl Mouse)
Cyp26c1
GeneProduct
ENSMUSG00000062432 (Ensembl Mouse)
Cyp27a1
GeneProduct
ENSMUSG00000026170 (Ensembl Mouse)
Cyp27b1
GeneProduct
ENSMUSG00000006724 (Ensembl Mouse)
Cyp2e1
GeneProduct
ENSMUSG00000025479 (Ensembl Mouse)
Cyp2f2
GeneProduct
ENSMUSG00000052974 (Ensembl Mouse)
Cyp2r1
GeneProduct
ENSMUSG00000030670 (Ensembl Mouse)
Cyp2s1
GeneProduct
ENSMUSG00000040703 (Ensembl Mouse)
Cyp2u1
GeneProduct
ENSMUSG00000027983 (Ensembl Mouse)
Cyp39a1
GeneProduct
ENSMUSG00000023963 (Ensembl Mouse)
Cyp46a1
GeneProduct
ENSMUSG00000021259 (Ensembl Mouse)
Cyp4b1
GeneProduct
ENSMUSG00000028713 (Ensembl Mouse)
Cyp4f18
GeneProduct
ENSMUSG00000003484 (Ensembl Mouse)
Cyp4f39
GeneProduct
ENSMUSG00000061126 (Ensembl Mouse)
Cyp4v3
GeneProduct
ENSMUSG00000079057 (Ensembl Mouse)
Cyp4x1
GeneProduct
ENSMUSG00000047155 (Ensembl Mouse)
Cyp51
GeneProduct
ENSMUSG00000001467 (Ensembl Mouse)
Cyp7a1
GeneProduct
ENSMUSG00000028240 (Ensembl Mouse)
Cyp7b1
GeneProduct
ENSMUSG00000039519 (Ensembl Mouse)
Cyp8b1
GeneProduct
ENSMUSG00000050445 (Ensembl Mouse)
Fe2+
Metabolite
29033 (ChEBI)
Fe3+
Metabolite
29034 (ChEBI)
NAD+
Metabolite
15846 (ChEBI)
NADH
Metabolite
16908 (ChEBI)
NADP+
Metabolite
18009 (ChEBI)
NADPH
Metabolite
16474 (ChEBI)
O2
Metabolite
HMDB01377 (HMDB)
Por
GeneProduct
ENSMUSG00000005514 (Ensembl Mouse)
Substrate
GeneProduct
Substrate-OH
GeneProduct
Water
Metabolite
HMDB02111 (HMDB)
activated O2
Metabolite
Annotated Interactions
No annotated interactions
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Pathway
Discussion
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View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
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No annotated interactions