HIF1A and PPARG in cardiac hypertropthy (Homo sapiens)

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PyruvateLDHHIF1AMyocardial SteatosisGlyceraldehyde-3-phosphateTPIFructose-1,6-biphosphateGADPHDihydroxyacetonephosphateLactateGlycerol-3-phosphateLysophosphatidateTriacylglycerolDiacylglycerolGPD1GPATGlucoseGLUT1PPARGHIF1A


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Krishnan J, Suter M, Windak R, Krebs T, Felley A, Montessuit C, Tokarska-Schlattner M, Aasum E, Bogdanova A, Perriard E, Perriard JC, Larsen T, Pedrazzini T, Krek W; ''Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.''; Cell Metab, 2009 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134929view23:56, 29 July 2024EweitzModified description
134928view23:56, 29 July 2024EweitzModified description
134924view23:16, 29 July 2024EweitzRefine alignment
134923view22:58, 29 July 2024EweitzRefine layout
134922view22:55, 29 July 2024EweitzGive pathway name more bottom margin
134921view22:53, 29 July 2024EweitzAdd background pathways for context: glycolysis, triacylglyceride synthesis
134920view21:41, 29 July 2024EweitzAdd vertical space
134919view21:41, 29 July 2024EweitzEconomize layout
134918view21:37, 29 July 2024EweitzAdd link to hypertrophic cardiomyopathy: in source text, though not source figure
134917view21:14, 29 July 2024EweitzAdd more content from source
134916view12:35, 29 July 2024EweitzAdd more content from source
134915view12:20, 29 July 2024EweitzModified title
134914view03:44, 29 July 2024EweitzOntology Term : 'lipid metabolic pathway' added !
134913view03:43, 29 July 2024EweitzOntology Term : 'hypertrophic cardiomyopathy' added !
134912view03:42, 29 July 2024EweitzModified title
134911view03:36, 29 July 2024EweitzEconomize layout
134910view03:32, 29 July 2024EweitzEconomize layout
134909view03:29, 29 July 2024EweitzOntology Term : 'cardiac muscle cell' added !
134908view03:28, 29 July 2024EweitzLabel cell type
134907view03:24, 29 July 2024EweitzAdd more content from source
134906view03:18, 29 July 2024EweitzAdd more content from source
134905view03:05, 29 July 2024EweitzAdd more from source: figure 6D in PMID 19490906
134902view22:05, 28 July 2024EweitzModified description
134901view22:05, 28 July 2024EweitzModified description
134899view21:36, 28 July 2024EweitzAdd literature reference
134898view21:35, 28 July 2024EweitzRemove obsolete, incorrect "Last modified" metadata
134897view21:34, 28 July 2024EweitzEconomize layout
134896view21:25, 28 July 2024EweitzImprove alignment, economize layout
134895view21:23, 28 July 2024EweitzIncrease font size for readability
134894view21:21, 28 July 2024EweitzStandardize case
134893view21:19, 28 July 2024EweitzEconomize layout
134892view21:16, 28 July 2024EweitzRemove HIF1A interactions that have no endpoint
119185view14:09, 21 June 2021FinterlyFixed unconnected line
107555view23:50, 19 October 2019AlexanderPicoModified description
105612view04:55, 10 August 2019KhanspersModified description
96297view16:18, 7 March 2018Fehrhartfixed connection
95512view01:15, 19 December 2017Khanspersupdated xrefs and lines
89610view12:34, 20 September 2016EveloOntology Term : 'glycolysis/gluconeogenesis pathway' added !
88642view14:59, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
71255view21:00, 16 October 2013MaintBotAutomated update of data sources
62280view00:50, 27 April 2013MaintBotFixed HIF1A xref
58978view19:04, 21 February 2013Maguirre1Corrected Database References
58791view22:45, 20 February 2013MaintBotModified categories
58711view20:02, 19 February 2013Maguirre1Fixed References
58710view19:50, 19 February 2013Maguirre1Title
58709view19:49, 19 February 2013Maguirre1Periodical save, work in progress
58708view19:39, 19 February 2013Maguirre1New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DiacylglycerolMetaboliteC00165 (Kegg Compound)
Dihydroxyacetone phosphateMetaboliteC00111 (Kegg Compound)
Fructose-1,6- biphosphateMetaboliteC05345 (Kegg Compound)
GADPHGeneProductK00134 (KEGG Orthology)
GLUT1GeneProductK07299 (KEGG Orthology)
GPATGeneProductK13508 (KEGG Orthology)
GPD1GeneProductK00006 (KEGG Orthology)
GlucoseMetaboliteC05345 (Kegg Compound)
Glyceraldehyde- 3-phosphateMetaboliteC00118 (Kegg Compound)
Glycerol-3- phosphateMetaboliteC00093 (Kegg Compound)
HIF1AGeneProductK08268
LDHGeneProduct
LactateMetaboliteC00186 (Kegg Compound)
LysophosphatidateMetaboliteC00681 (Kegg Compound)
Myocardial SteatosisPathway
PPARGGeneProductK08530
PyruvateMetaboliteC00022 (Kegg Compound)
TPIGeneProduct
TriacylglycerolMetaboliteC00422 (Kegg Compound)

Annotated Interactions

No annotated interactions

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