HIF1A and PPARG in hypertrophic cardiomyopathy (Homo sapiens)

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Description

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Ontology Terms

Pathway Ontology : disease pathway classic metabolic pathway steroid biosynthetic pathway glucocorticoid biosynthetic pathway C19-steroid hormone biosynthetic pathway apparent mineralocorticoid excess syndrome pathway congenital adrenal hyperplasia pathway C21-steroid hormone biosynthetic pathway lipoid congenital adrenal hyperplasia pathway

Disease : apparent mineralocorticoid excess congenital adrenal insufficiency pseudohermaphroditism congenital adrenal hyperplasia cortisone reductase deficiency apparent mineralocorticoid excess syndrome

Bibliography

Krishnan J, Suter M, Windak R, Krebs T, Felley A, Montessuit C, Tokarska-Schlattner M, Aasum E, Bogdanova A, Perriard E, Perriard JC, Larsen T, Pedrazzini T, Krek W; ''Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.''; Cell Metab, 2009 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
137811	view	06:38, 8 March 2025	Egonw	Modified description
136423	view	03:13, 2 February 2025	Eweitz	Modified title
134929	view	23:56, 29 July 2024	Eweitz	Modified description
134928	view	23:56, 29 July 2024	Eweitz	Modified description
134924	view	23:16, 29 July 2024	Eweitz	Refine alignment
134923	view	22:58, 29 July 2024	Eweitz	Refine layout
134922	view	22:55, 29 July 2024	Eweitz	Give pathway name more bottom margin
134921	view	22:53, 29 July 2024	Eweitz	Add background pathways for context: glycolysis, triacylglyceride synthesis
134920	view	21:41, 29 July 2024	Eweitz	Add vertical space
134919	view	21:41, 29 July 2024	Eweitz	Economize layout
134918	view	21:37, 29 July 2024	Eweitz	Add link to hypertrophic cardiomyopathy: in source text, though not source figure
134917	view	21:14, 29 July 2024	Eweitz	Add more content from source
134916	view	12:35, 29 July 2024	Eweitz	Add more content from source
134915	view	12:20, 29 July 2024	Eweitz	Modified title
134914	view	03:44, 29 July 2024	Eweitz	Ontology Term : 'lipid metabolic pathway' added !
134913	view	03:43, 29 July 2024	Eweitz	Ontology Term : 'hypertrophic cardiomyopathy' added !
134912	view	03:42, 29 July 2024	Eweitz	Modified title
134911	view	03:36, 29 July 2024	Eweitz	Economize layout
134910	view	03:32, 29 July 2024	Eweitz	Economize layout
134909	view	03:29, 29 July 2024	Eweitz	Ontology Term : 'cardiac muscle cell' added !
134908	view	03:28, 29 July 2024	Eweitz	Label cell type
134907	view	03:24, 29 July 2024	Eweitz	Add more content from source
134906	view	03:18, 29 July 2024	Eweitz	Add more content from source
134905	view	03:05, 29 July 2024	Eweitz	Add more from source: figure 6D in PMID 19490906
134902	view	22:05, 28 July 2024	Eweitz	Modified description
134901	view	22:05, 28 July 2024	Eweitz	Modified description
134899	view	21:36, 28 July 2024	Eweitz	Add literature reference
134898	view	21:35, 28 July 2024	Eweitz	Remove obsolete, incorrect "Last modified" metadata
134897	view	21:34, 28 July 2024	Eweitz	Economize layout
134896	view	21:25, 28 July 2024	Eweitz	Improve alignment, economize layout
134895	view	21:23, 28 July 2024	Eweitz	Increase font size for readability
134894	view	21:21, 28 July 2024	Eweitz	Standardize case
134893	view	21:19, 28 July 2024	Eweitz	Economize layout
134892	view	21:16, 28 July 2024	Eweitz	Remove HIF1A interactions that have no endpoint
119185	view	14:09, 21 June 2021	Finterly	Fixed unconnected line
107555	view	23:50, 19 October 2019	AlexanderPico	Modified description
105612	view	04:55, 10 August 2019	Khanspers	Modified description
96297	view	16:18, 7 March 2018	Fehrhart	fixed connection
95512	view	01:15, 19 December 2017	Khanspers	updated xrefs and lines
89610	view	12:34, 20 September 2016	Evelo	Ontology Term : 'glycolysis/gluconeogenesis pathway' added !
88642	view	14:59, 12 August 2016	Jmelius	Ontology Term : 'regulatory pathway' added !
71255	view	21:00, 16 October 2013	MaintBot	Automated update of data sources
62280	view	00:50, 27 April 2013	MaintBot	Fixed HIF1A xref
58978	view	19:04, 21 February 2013	Maguirre1	Corrected Database References
58791	view	22:45, 20 February 2013	MaintBot	Modified categories
58711	view	20:02, 19 February 2013	Maguirre1	Fixed References
58710	view	19:50, 19 February 2013	Maguirre1	Title
58709	view	19:49, 19 February 2013	Maguirre1	Periodical save, work in progress
58708	view	19:39, 19 February 2013	Maguirre1	New pathway

External references

DataNodes

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Name	Type	Database reference
Diacylglycerol	Metabolite	C00165 (Kegg Compound)
Dihydroxyacetone phosphate	Metabolite	C00111 (Kegg Compound)
Fructose-1,6- biphosphate	Metabolite	C05345 (Kegg Compound)
GADPH	GeneProduct	K00134 (KEGG Orthology)
GLUT1	GeneProduct	K07299 (KEGG Orthology)
GPAT	GeneProduct	K13508 (KEGG Orthology)
GPD1	GeneProduct	K00006 (KEGG Orthology)
Glucose	Metabolite	C05345 (Kegg Compound)
Glyceraldehyde- 3-phosphate	Metabolite	C00118 (Kegg Compound)
Glycerol-3- phosphate	Metabolite	C00093 (Kegg Compound)
HIF1A	GeneProduct	K08268
HIF1A	GeneProduct	K08268 (KEGG Orthology)
LDH	GeneProduct	K00016 (KEGG Orthology)
Lactate	Metabolite	C00186 (Kegg Compound)
Lysophosphatidate	Metabolite	C00681 (Kegg Compound)
Myocardial Steatosis	Pathway
PPARG	GeneProduct	K08530 (KEGG Orthology)
Pyruvate	Metabolite	C00022 (Kegg Compound)
TPI	GeneProduct	K01803 (KEGG Orthology)
Triacylglycerol	Metabolite	C00422 (Kegg Compound)