Spinal cord injury (Rattus norvegicus)

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367Ltb4rTnfsf13NgfrPlxna2LTB4Cd47LtbTnfsf13bCspg4Ptprz1PdynNO291420933Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZfp36Fcgr2aPrb1PtpraIl1bZfp36Nos2TnfNr4a1Il4Btg2Btg2FBRCdk2Nos1Il2TnfIl6Tlr4FosIl1bTgfb1Tlr4TnfEgr1FosMmp12IfngGlial ScarAstrocyte GliosisSwelling/EdemaMbpAntigens ReleasedRtn4C5Cxcl1Neutrophil ChemoattractantsIL821, 22NeurtrophilsMonocytesAqp440TTLegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating4Activated Microglia/Macrophages(Transient)RepairIl1bNos2TnfArg1TOXIC FERROUSIRONFocal Adensions8, 28Epha4TTEfnb2TTTTTTTTCxcl10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)24Ccng1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMmp9TT5Chondroitin Sulfate Proteoglycans2NcanSlit1Axon RetractionSlit22Slit3Ntn1RgmaTTTTTTTTTTMmp9Mmp95Mmp955TTTTTTCcr2Il1r1TT22ECM BreakdownECM BreakdownIl1aCxcl1Monocyte Chemoattractants21, 22Cxcl2Ccl2OligodendrocyteInjury ResponsePla2g6Pla2g5Pla2g2amelittinInflammationDemyelinationAnxa115TTTTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion FactorsIcam132SelpTTTTPlasticityKlk8TT27MicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGfapTT5IntermediateFillament23Cdk4Tacr1E2f5Rb1PrkcaE2f1Mapk1Ccnd1MycGadd45aMapk3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationCasp3Tp53CytotoxicCytotoxicChst11VcanCol4a1Xylt1Col2a1AcanBcanGlial Scar FromationSox9Axonal GrowthInhibition23IgG, IgMTp5339TTTTTTGrin1Vim26TT42T Cell StimulatingFK506435Ppp3caTTFK506FK5063030Gap43TTFK506Axonal Regeneration30Fkbp1aIl2C3 ToxinC1Q and Fc receptive cellsMagRtn4RhoaRhocRhobRock2OmgRtn4rLilrb331MyelinInjury ResponseArachidonic acidPGH2PTGS237TT18ROSNox4Mir23bOlomoucine17Cdk1Gdnf1TTSema6aTT29Axonal GrowthInhibitionGja1ATP-Release6TTBdnfTTImmediate Response Genes24


Description

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
120271view12:47, 23 November 2021EgonwRemoved whitespace in the pubmed id
117015view11:25, 16 May 2021EweitzModified title
106971view13:43, 17 September 2019MaintBotHMDB identifier normalization
87680view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
83002view05:04, 17 November 2015Mkutmonremoved redundant refrence
83001view05:01, 17 November 2015Mkutmonfixed errors in references
83000view04:40, 17 November 2015Mkutmonfix outdated identifiers
81936view00:13, 6 September 2015AlexanderPicoNo rat homolog for IL8; removed human xref
79923view11:26, 27 April 2015EveloFixed homolog issue for C5
79916view11:01, 27 April 2015EveloCorrected datasource for ENSG00000106804 (was gene cards should have been ENSEMBL), still needs replaced by rat homologe
78470view10:27, 7 January 2015MaintBotadded missing graphIds
71102view17:16, 4 October 2013DMicaelModified description
69987view22:02, 11 July 2013MaintBotupdated to 2013 schema
58948view18:14, 21 February 2013MaintBotUpdated Ensembl data source
57152view12:40, 23 January 2013EgonwUsed "PubChem-compound"
55949view23:18, 28 December 2012NsalomonisOntology Term : 'traumatic neurosis' added !
55948view23:17, 28 December 2012NsalomonisOntology Term : 'spinal cord disease' added !
55947view23:17, 28 December 2012NsalomonisOntology Term : 'astrocyte of the spinal cord' added !
55946view23:15, 28 December 2012NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProductENSRNOG00000028992 (Ensembl)
Anxa1GeneProductENSRNOG00000017469 (Ensembl)
Aqp4GeneProductENSRNOG00000016043 (Ensembl)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
Arg1GeneProductENSRNOG00000013304 (Ensembl)
BcanGeneProductENSRNOG00000018798 (Ensembl)
BdnfGeneProduct24225 (Entrez Gene)
Btg2GeneProductENSRNOG00000003300 (Ensembl)
C5GeneProductENSG00000106804 (CTD Gene)
Casp3GeneProductENSRNOG00000010475 (Ensembl)
Ccl2GeneProductENSRNOG00000007159 (Ensembl)
Ccnd1GeneProductENSRNOG00000020918 (Ensembl)
Ccng1GeneProductENSRNOG00000003256 (Ensembl)
Ccr2GeneProductENSRNOG00000006755 (Ensembl)
Cd47GeneProductENSRNOG00000001964 (Ensembl)
Cdk1GeneProductENSRNOG00000000632 (Ensembl)
Cdk2GeneProductENSRNOG00000006469 (Ensembl)
Cdk4GeneProductENSRNOG00000025602 (Ensembl)
Chst11GeneProductENSRNOG00000008885 (Ensembl)
Col2a1GeneProductENSRNOG00000022282 (Ensembl)
Col4a1GeneProductENSRNOG00000016281 (Ensembl)
Cspg4GeneProductENSRNOG00000017208 (Ensembl)
Cxcl10GeneProductENSRNOG00000022256 (Ensembl)
Cxcl1GeneProductENSRNOG00000002802 (Ensembl)
Cxcl2GeneProductENSRNOG00000002792 (Ensembl)
E2f1GeneProductENSRNOG00000016708 (Ensembl)
E2f5GeneProductENSRNOG00000010760 (Ensembl)
Efnb2GeneProductENSRNOG00000014648 (Ensembl)
Egr1GeneProductENSRNOG00000019422 (Ensembl)
Epha4GeneProductENSRNOG00000013213 (Ensembl)
FBRGeneProduct
FK506Metabolite104987-11-3 (CAS)
Fcgr2aGeneProductENSRNOG00000003138 (Ensembl)
Fkbp1aGeneProductENSRNOG00000008822 (Ensembl)
FosGeneProductENSRNOG00000008015 (Ensembl)
Gadd45aGeneProductENSRNOG00000005615 (Ensembl)
Gap43GeneProductENSRNOG00000001528 (Ensembl)
GdnfGeneProductENSRNOG00000012819 (Ensembl)
GfapGeneProductENSRNOG00000002919 (Ensembl)
Gja1GeneProductENSRNOG00000000805 (Ensembl)
Grin1GeneProductENSRNOG00000011726 (Ensembl)
IL8GeneProductENSG00000169429 (Ensembl)
Icam1GeneProductENSRNOG00000020679 (Ensembl)
IfngGeneProductENSRNOG00000007468 (Ensembl)
Il1aGeneProductENSRNOG00000004575 (Ensembl)
Il1bGeneProductENSRNOG00000004649 (Ensembl)
Il1r1GeneProductENSRNOG00000014504 (Ensembl)
Il2GeneProductENSRNOG00000017348 (Ensembl)
Il4GeneProductENSRNOG00000007624 (Ensembl)
Il6GeneProductENSRNOG00000010278 (Ensembl)
Klk8GeneProductENSRNOG00000018580 (Ensembl)
LTB4Metabolite169 (PubChem-compound)
Lilrb3GeneProductENSRNOG00000011236 (Ensembl)
Ltb4rGeneProductENSRNOG00000020399 (Ensembl)
LtbGeneProductENSRNOG00000000836 (Ensembl)
MagGeneProductENSRNOG00000021023 (Ensembl)
Mapk1GeneProductENSRNOG00000001849 (Ensembl)
Mapk3GeneProductENSRNOG00000019601 (Ensembl)
MbpGeneProductENSRNOG00000016516 (Ensembl)
Mir23bGeneProduct100314002 (Entrez Gene)
Mmp12GeneProductENSRNOG00000030187 (Ensembl)
Mmp9GeneProductENSRNOG00000017539 (Ensembl)
MycGeneProductENSRNOG00000004500 (Ensembl)
NOMetabolite145068 (PubChem-compound)
NcanGeneProductENSRNOG00000020448 (Ensembl)
NgfrGeneProductENSRNOG00000005392 (Ensembl)
Nos1GeneProductENSRNOG00000001130 (Ensembl)
Nos2GeneProductENSRNOG00000011023 (Ensembl)
Nox4GeneProductENSRNOG00000013925 (Ensembl)
Nr4a1GeneProductENSRNOG00000007607 (Ensembl)
Ntn1GeneProductENSRNOG00000003947 (Ensembl)
OlomoucineMetaboliteHMDB35233 (HMDB)
OmgGeneProductENSRNOG00000014107 (Ensembl)
PGH2MetaboliteHMDB01381 (HMDB)
PTGS2GeneProduct469616 (Entrez Gene)
PdynGeneProductENSRNOG00000026036 (Ensembl)
Pla2g2aGeneProductENSRNOG00000016945 (Ensembl)
Pla2g5GeneProductENSRNOG00000016838 (Ensembl)
Pla2g6GeneProductENSRNOG00000012295 (Ensembl)
Plxna2GeneProductENSRNOG00000007324 (Ensembl)
Ppp3caGeneProductENSRNOG00000009882 (Ensembl)
Prb1GeneProductENSRNOG00000010485 (Ensembl)
PrkcaGeneProductENSRNOG00000003491 (Ensembl)
PtpraGeneProductENSRNOG00000021223 (Ensembl)
Ptprz1GeneProductENSRNOG00000006030 (Ensembl)
ROSGeneProduct
Rb1GeneProductENSRNOG00000016029 (Ensembl)
RgmaGeneProductENSRNOG00000012874 (Ensembl)
RhoaGeneProductENSRNOG00000002491 (Ensembl)
RhobGeneProductENSRNOG00000021403 (Ensembl)
RhocGeneProductENSRNOG00000012630 (Ensembl)
Rock2GeneProductENSRNOG00000004496 (Ensembl)
Rtn4GeneProductENSRNOG00000004621 (Ensembl)
Rtn4rGeneProductENSRNOG00000030920 (Ensembl)
SelpGeneProductENSRNOG00000002794 (Ensembl)
Sema6aGeneProduct361324 (Entrez Gene)
Slit1GeneProductENSRNOG00000026065 (Ensembl)
Slit2GeneProductENSRNOG00000003840 (Ensembl)
Slit3GeneProductENSRNOG00000007377 (Ensembl)
Sox9GeneProduct140586 (Entrez Gene)
Tacr1GeneProductENSRNOG00000005853 (Ensembl)
Tgfb1GeneProductENSRNOG00000020652 (Ensembl)
Tlr4GeneProductENSRNOG00000010522 (Ensembl)
TnfGeneProductENSRNOG00000000837 (Ensembl)
Tnfsf13GeneProductENSRNOG00000014171 (Ensembl)
Tnfsf13bGeneProductENSRNOG00000014464 (Ensembl)
Tp53GeneProductENSRNOG00000010756 (Ensembl)
VcanGeneProductENSRNOG00000029212 (Ensembl)
VimGeneProductENSRNOG00000018087 (Ensembl)
Xylt1GeneProductENSRNOG00000018459 (Ensembl)
Zfp36GeneProductENSRNOG00000019673 (Ensembl)
melittinMetabolite16133648 (PubChem-compound)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2433"
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