Spinal cord injury (Mus musculus)

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2234Plxna2NONgfrLTB4Cspg4Tnfsf13bLtb4r1LtbPdynTnfsf13Ptprz1Cd4781727633Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZfp36Fcgr2bPrb1PtpraIl1bZfp36Nos2TnfNr4a1Il4Btg2Btg2FBRCdk2Nos1Il2TnfIl6Tlr4FosIl1bTgfb1Tlr4TnfEgr1FosMmp12IfngGlial ScarAstrocyte GliosisSwelling/EdemaMbpAntigens ReleasedRtn4C5Cxcl1Neutrophil ChemoattractantsCxcl15, 31NeurtrophilsMonocytesAqp47TTLegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating41Activated Microglia/Macrophages(Transient)RepairIl1bNos2TnfArg1TOXIC FERROUSIRONFocal Adensions3, 21Epha4TTEfnb2TTTTTTTTCxcl10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)1Ccng1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMmp939TTChondroitin Sulfate ProteoglycansNcan15Slit1Axon RetractionSlit215Slit3Ntn1RgmaTTTTTTTTTTMmp939Mmp9Mmp93939TTTTTTCcr2Il1r1TT31ECM BreakdownECM BreakdownIl1aCxcl1Monocyte ChemoattractantsCxcl25, 31Ccl2OligodendrocyteInjury ResponsePla2g6Pla2g5Pla2g2amelittinInflammationDemyelinationAnxa1TT18TTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion Factors19Icam1SelpTTTTPlasticityKlk8TT14MicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGfap39TTIntermediateFillament10Cdk4Tacr1E2f5Rb1PrkcaE2f1Mapk1Ccnd1MycGadd45aMapk3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationCasp3Trp53CytotoxicCytotoxicChst11VcanCol4a1Xylt1Col2a1AcanBcanGlial Scar FromationSox9Axonal GrowthInhibition10IgG, IgMTrp532TTTTTTGrin125Vim32TTT Cell Stimulating41FK50640Ppp3caTTFK506FK5062929Gap43TTFK50629Axonal RegenerationFkbp1aIl2C3 ToxinC1Q and Fc receptive cellsMagRtn4RhoaRhocRhobRock2OmgRtn4rLilrb313MyelinInjury ResponseArachidonic acidPGH2PTGS216TT28ROSNox4Mir23bOlomoucine20Cdk1Gdnf24TTSema6aTT17Axonal GrowthInhibitionGja1ATP-Release38TTBdnfTTImmediate Response Genes1


Description

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116842view10:32, 14 May 2021EweitzModified title
106874view13:35, 17 September 2019MaintBotHMDB identifier normalization
102465view05:52, 24 December 2018EgonwFixed a reference.
102464view05:51, 24 December 2018EgonwFixed a data source.
87679view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
79927view12:02, 27 April 2015EveloReplaced human C5 gene with mouse homologe Hc
79915view10:57, 27 April 2015EveloCorrected datasource for: ENSG00000106804 (was gene cards, should have been ensembl)
78436view10:26, 7 January 2015MaintBotadded missing graphIds
71041view01:36, 25 September 2013DMicaelModified description
69986view22:01, 11 July 2013MaintBotupdated to 2013 schema
59003view20:15, 21 February 2013MaintBotUpdated Ensembl data source
57151view12:39, 23 January 2013EgonwUsed "PubChem-compound"
55957view00:47, 29 December 2012NsalomonisSpecify description
55952view00:20, 29 December 2012Nsalomonisre-sized fonts and spacing for image export
55943view22:52, 28 December 2012NsalomonisOntology Term : 'traumatic neurosis' added !
55942view22:51, 28 December 2012NsalomonisOntology Term : 'spinal cord disease' added !
55941view22:51, 28 December 2012NsalomonisOntology Term : 'astrocyte of the spinal cord' added !
55940view22:49, 28 December 2012NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProductENSMUSG00000030607 (Ensembl)
Anxa1GeneProductENSMUSG00000024659 (Ensembl)
Aqp4GeneProductENSMUSG00000024411 (Ensembl)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
Arg1GeneProductENSMUSG00000019987 (Ensembl)
BcanGeneProductENSMUSG00000004892 (Ensembl)
BdnfGeneProductENSMUSG00000048482 (Ensembl)
Btg2GeneProductENSMUSG00000020423 (Ensembl)
C5GeneProductENSG00000106804 (CTD Gene)
Casp3GeneProductENSMUSG00000031628 (Ensembl)
Ccl2GeneProductENSMUSG00000035385 (Ensembl)
Ccnd1GeneProductENSMUSG00000070348 (Ensembl)
Ccng1GeneProductENSMUSG00000020326 (Ensembl)
Ccr2GeneProductENSMUSG00000049103 (Ensembl)
Cd47GeneProductENSMUSG00000055447 (Ensembl)
Cdk1GeneProductENSMUSG00000019942 (Ensembl)
Cdk2GeneProductENSMUSG00000025358 (Ensembl)
Cdk4GeneProductENSMUSG00000006728 (Ensembl)
Chst11GeneProductENSMUSG00000034612 (Ensembl)
Col2a1GeneProductENSMUSG00000022483 (Ensembl)
Col4a1GeneProductENSMUSG00000031502 (Ensembl)
Cspg4GeneProductENSMUSG00000032911 (Ensembl)
Cxcl10GeneProductENSMUSG00000034855 (Ensembl)
Cxcl1GeneProductENSMUSG00000029380 (Ensembl)
Cxcl2GeneProductENSMUSG00000058427 (Ensembl)
E2f1GeneProductENSMUSG00000027490 (Ensembl)
E2f5GeneProductENSMUSG00000027552 (Ensembl)
Efnb2GeneProductENSMUSG00000001300 (Ensembl)
Egr1GeneProductENSMUSG00000038418 (Ensembl)
Epha4GeneProductENSMUSG00000026235 (Ensembl)
FBRGeneProduct
FK506Metabolite104987-11-3 (CAS)
Fcgr2bGeneProductENSMUSG00000026656 (Ensembl)
Fkbp1aGeneProductENSMUSG00000032966 (Ensembl)
FosGeneProductENSMUSG00000021250 (Ensembl)
Gadd45aGeneProductENSMUSG00000036390 (Ensembl)
Gap43GeneProductENSMUSG00000047261 (Ensembl)
GdnfGeneProductENSMUSG00000022144 (Ensembl)
GfapGeneProductENSMUSG00000020932 (Ensembl)
Gja1GeneProductENSMUSG00000050953 (Ensembl)
Grin1GeneProductENSMUSG00000026959 (Ensembl)
Icam1GeneProductENSMUSG00000037405 (Ensembl)
IfngGeneProductENSMUSG00000055170 (Ensembl)
Il1aGeneProductENSMUSG00000027399 (Ensembl)
Il1bGeneProductENSMUSG00000027398 (Ensembl)
Il1r1GeneProductENSMUSG00000026072 (Ensembl)
Il2GeneProductENSMUSG00000027720 (Ensembl)
Il4GeneProductENSMUSG00000000869 (Ensembl)
Il6GeneProductENSMUSG00000025746 (Ensembl)
Klk8GeneProductENSMUSG00000064023 (Ensembl)
LTB4Metabolite169 (PubChem-compound)
Lilrb3GeneProductENSMUSG00000058818 (Ensembl)
Ltb4r1GeneProductENSMUSG00000046908 (Ensembl)
LtbGeneProductENSMUSG00000024399 (Ensembl)
MagGeneProductENSMUSG00000036634 (Ensembl)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mapk3GeneProductENSMUSG00000063065 (Ensembl)
MbpGeneProductENSMUSG00000041607 (Ensembl)
Mir23bGeneProductENSMUSG00000065599 (Ensembl)
Mmp12GeneProductENSMUSG00000049723 (Ensembl)
Mmp9GeneProductENSMUSG00000017737 (Ensembl)
MycGeneProductENSMUSG00000022346 (Ensembl)
NOMetabolite145068 (PubChem-compound)
NcanGeneProductENSMUSG00000002341 (Ensembl)
NgfrGeneProductENSMUSG00000000120 (Ensembl)
Nos1GeneProductENSMUSG00000029361 (Ensembl)
Nos2GeneProductENSMUSG00000020826 (Ensembl)
Nox4GeneProductENSMUSG00000030562 (Ensembl)
Nr4a1GeneProductENSMUSG00000023034 (Ensembl)
Ntn1GeneProductENSMUSG00000020902 (Ensembl)
OlomoucineMetaboliteHMDB35233 (HMDB)
OmgGeneProductENSMUSG00000049612 (Ensembl)
PGH2MetaboliteHMDB01381 (HMDB)
PTGS2GeneProduct469616 (Entrez Gene)
PdynGeneProductENSMUSG00000027400 (Ensembl)
Pla2g2aGeneProductENSMUSG00000058908 (Ensembl)
Pla2g5GeneProductENSMUSG00000041193 (Ensembl)
Pla2g6GeneProductENSMUSG00000042632 (Ensembl)
Plxna2GeneProductENSMUSG00000026640 (Ensembl)
Ppp3caGeneProductENSMUSG00000028161 (Ensembl)
Prb1GeneProductENSMUSG00000067543 (Ensembl)
PrkcaGeneProductENSMUSG00000050965 (Ensembl)
PtpraGeneProductENSMUSG00000027303 (Ensembl)
Ptprz1GeneProductENSMUSG00000068748 (Ensembl)
ROSGeneProduct
Rb1GeneProductENSMUSG00000022105 (Ensembl)
RgmaGeneProductENSMUSG00000070509 (Ensembl)
RhoaGeneProductENSMUSG00000007815 (Ensembl)
RhobGeneProductENSMUSG00000054364 (Ensembl)
RhocGeneProductENSMUSG00000002233 (Ensembl)
Rock2GeneProductENSMUSG00000020580 (Ensembl)
Rtn4GeneProductENSMUSG00000020458 (Ensembl)
Rtn4rGeneProductENSMUSG00000043811 (Ensembl)
SelpGeneProductENSMUSG00000026580 (Ensembl)
Sema6aGeneProductENSMUSG00000019647 (Ensembl)
Slit1GeneProductENSMUSG00000025020 (Ensembl)
Slit2GeneProductENSMUSG00000031558 (Ensembl)
Slit3GeneProductENSMUSG00000056427 (Ensembl)
Sox9GeneProductENSMUSG00000000567 (Ensembl)
Tacr1GeneProductENSMUSG00000030043 (Ensembl)
Tgfb1GeneProductENSMUSG00000002603 (Ensembl)
Tlr4GeneProductENSMUSG00000039005 (Ensembl)
TnfGeneProductENSMUSG00000024401 (Ensembl)
Tnfsf13GeneProductENSMUSG00000089669 (Ensembl)
Tnfsf13bGeneProductENSMUSG00000031497 (Ensembl)
Trp53GeneProductENSMUSG00000059552 (Ensembl)
VcanGeneProductENSMUSG00000021614 (Ensembl)
VimGeneProductENSMUSG00000026728 (Ensembl)
Xylt1GeneProductENSMUSG00000030657 (Ensembl)
Zfp36GeneProductENSMUSG00000044786 (Ensembl)
melittinMetabolite16133648 (PubChem-compound)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2432"
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