Regulation of cardiac hypertrophy by miR-208 (Mus musculus)

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βMHCαMHC21Knock-outAtrial fibrilationsProlonged PR interval, abberand conductionmiR-208bNucleusmiR-208aOverexpressionHypertrophyβMHCCx40Trap1miR-208bGata4miR-208aMyostatinHop


Description

MicroRNA-208a regulates cardiac hypertrophy pathways in mice. MicroRNAs are shown in purple. Knock out and overexpression of miR-208a are shown in blue. Processes are shown at the top and include hypertrophy, atrial fibrilation and prolonged PR interval & abberand conduction.

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Bibliography

  1. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ; ''MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.''; J Clin Invest, 2009 PubMed Europe PMC Scholia
  2. Lo CW; ''Role of gap junctions in cardiac conduction and development: insights from the connexin knockout mice.''; Circ Res, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126388view10:33, 26 April 2023EgonwLicense is CCZero
116841view10:31, 14 May 2021EweitzModified title
87631view08:54, 25 July 2016LindarieswijkOntology Term : 'hypertrophic cardiomyopathy pathway' added !
73503view23:11, 29 January 2014KhanspersModified title
69926view19:50, 11 July 2013Mkutmonfixed unconnected lines
69924view19:50, 11 July 2013MkutmonPeriodical save, work in progress
59045view20:46, 21 February 2013MaintBotUpdated Ensembl data source
41320view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
36815view08:12, 6 May 2010MLevelsModified categories
36798view11:58, 4 May 2010MLevelsMinor changes
36796view11:53, 4 May 2010SusanPeriodical save, work in progress
36791view10:22, 4 May 2010MLevelsModified description
36790view10:20, 4 May 2010MLevels
36789view10:20, 4 May 2010MLevelsMoved a line
36788view10:18, 4 May 2010MLevelsChanged Title
36787view10:15, 4 May 2010MLevelsModified description
36786view10:14, 4 May 2010MLevelsModified description
36785view10:09, 4 May 2010MLevelsMoving items
36784view10:07, 4 May 2010MLevelsPeriodical save, work in progress
36783view09:57, 4 May 2010MLevelsPeriodical save, work in progress
36782view09:37, 4 May 2010MLevelsPeriodical save, work in progress
36781view09:25, 4 May 2010MLevelsPeriodical save, work in progress
36780view09:06, 4 May 2010MLevelsMoving items
36778view08:56, 4 May 2010SusanSpecify description
36777view08:49, 4 May 2010SusanMinor adaptation
36755view08:19, 28 April 2010SusanPeriodical save, work in progress
36751view13:42, 27 April 2010MLevelsAdded color to the micro RNAs
36750view13:11, 27 April 2010MLevelsAdded Entrez Gene number for miR-208b
36749view09:18, 27 April 2010MLevelsMoved some items
36748view09:09, 27 April 2010MLevelsPathway Made
36747view09:02, 27 April 2010MLevelsPeriodical save, work in progress
36746view08:52, 27 April 2010MLevelsPeriodical save, work in progress
36745view08:42, 27 April 2010MLevelsPeriodical save, work in progress
36744view08:31, 27 April 2010MLevelsPeriodical save, work in progress
36742view08:21, 27 April 2010MLevelsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Cx40Protein14613 (Entrez Gene)
Gata4GeneProduct14463 (Entrez Gene)
HopGeneProduct74318 (Entrez Gene)
MyostatinProtein17700 (Entrez Gene)
Trap1Protein327987 (Entrez Gene)
miR-208aRnaMI0000555 (miRBase)
miR-208bRnaENSMUSG00000077928 (Ensembl) MI0005552
βMHCGeneProduct140781 (Entrez Gene)

Annotated Interactions

No annotated interactions

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