miRNAs involved in DNA damage response (Homo sapiens)

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1615, 24202012, 17, 2315283114201312722152820131622251953116297, 9161021, 28151126157, 93034, 681461618gene product used more than once in this pathwaygene productmicroRNA clusteractivationmicroRNAconsistsofinhibitionhsa-miR-424/450b clusterhsa-mir-203hsa-mir-372hsa-mir-371/373 clusterhsa-mir-449ahsa-mir-145ABL1hsa-mir-450bhsa-mir-195hsa-miR-222/221 clusterhsa-mir-15ahsa-mir-371CCNE1hsa-mir-27bE2F1CCND3hsa-mir-143/145 clusterhsa-mir-210hsa-let-7a-1/7d clusterhsa-mir-143CDKN1Ac-Mychsa-mir-181ahas-miR-195/497 clusterhsa-mir-449bhsa-miR-203 genec-Mychsa-mir-16hsa-mir-29chsa-mir-23bhsa-mir-19ahsa-mir-23b/24-1 clusterhsa-mir-27ahsa-mir-15a/16-1 clusterCCND1hsa-mir-24hsa-mir-21CDKN1Bhsa-miR-449c/449a clusterCREB1ATMhsa-mir-421hsa-mir-29bhsa-miR-223 genehsa-mir-25hsa-mir-542hsa-mir-106bhsa-miR-210 genehsa-let-7bhsa-mir-181bhsa-let-7dhsa-mir-34b/34c clusterCDC25A2hsa-mir-17hsa-mir-34chsa-miR-29b-2/29c clusterhsa-mir-29aCDK6RAD52hsa-mir-330H2AFXhas-mir-181a-1/181b-1 clusterhsa-miR-17/92a-1 clusterhsa-mir-34bhsa-mir-23ahsa-mir-20ahsa-mir-450ahsa-mir-374bhsa-mir-497hsa-mir-503hsa-mir-92aE2F1hsa-mir-15b/16-2 clusterhsa-miR-330 geneCCND1hsa-mir-222hsa-mir-221hsa-mir-100hsa-mir-424hsa-miR-106b/25 clusterhsa-mir-373hsa-mir-223hsa-mir-23a/24-2 clusterhas-mir-181a-2/181b-2 clusterhsa-mir-15bhsa-miR-29b-1/29a clusterhsa-mir-18ahsa-let-7fhsa-let-7ahsa-mir-374b/421 clusterTP53has-let-7a-2/100 clusterhsa-mir-19bhsa-mir-449chsa-miR-21genehsa-mir-3074hsa-mir-93hsa-let-7a-3/7b cluster


Description

MicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo sapiens)". More info can be found there.

Comments

 
This pathway show all microRNA gene cluster involed in the wikipathway pathway "DNA damage response (Homo sapiens)". More info can be found there.

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Bibliography

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  3. Ivanovska I, Ball AS, Diaz RL, Magnus JF, Kibukawa M, Schelter JM, Kobayashi SV, Lim L, Burchard J, Jackson AL, Linsley PS, Cleary MA; ''MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  4. Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, Yu J; ''microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  5. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM; ''MicroRNA regulation of DNA repair gene expression in hypoxic stress.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  6. Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G; ''Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.''; Blood, 2010 PubMed Europe PMC Scholia
  7. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY; ''p53 represses c-Myc through induction of the tumor suppressor miR-145.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
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  9. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, Yu Q; ''miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.''; Genes Dev, 2009 PubMed Europe PMC Scholia
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  11. Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M; ''MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.''; Oncogene, 2008 PubMed Europe PMC Scholia
  12. Quintavalle M, Elia L, Condorelli G, Courtneidge SA; ''MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro.''; J Cell Biol, 2010 PubMed Europe PMC Scholia
  13. Pigazzi M, Manara E, Baron E, Basso G; ''miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  14. Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML; ''The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.''; Cancer Res, 2010 PubMed Europe PMC Scholia
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  17. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY; ''MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth.''; Cancer Res, 2007 PubMed Europe PMC Scholia
  18. Yamakuchi M, Lowenstein CJ; ''MiR-34, SIRT1 and p53: the feedback loop.''; Cell Cycle, 2009 PubMed Europe PMC Scholia
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  21. Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG, Lu PJ; ''MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.''; Oncogene, 2009 PubMed Europe PMC Scholia
  22. Bueno MJ, Gómez de Cedrón M, Laresgoiti U, Fernández-Piqueras J, Zubiaga AM, Malumbres M; ''Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  23. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P; ''An E2F/miR-20a autoregulatory feedback loop.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  24. Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D; ''miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
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  26. Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA; ''ATM is down-regulated by N-Myc-regulated microRNA-421.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  27. Cuesta R, Martínez-Sánchez A, Gebauer F; ''miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells.''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia
  28. Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N; ''MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
118363view13:43, 27 May 2021Mkutmonremove unused publication ref
105864view23:21, 15 August 2019KhanspersModified description
102985view12:29, 31 January 2019SusanUpdated microRNA annotations
102984view11:59, 31 January 2019SusanAdapted annotation of microRNAs hsa-mir-497 and hsa-mir-20a
98356view05:43, 24 August 2018EgonwFixed weird chars in author names.
98338view13:28, 23 August 2018EgonwUpdated the MIR21 identifier.
94759view15:43, 5 October 2017Mkutmonlines in legend changed to graphical lines
84697view21:15, 15 March 2016KhanspersQuick edit to datanode annotation or property
78559view10:31, 7 January 2015MaintBotadded missing graphIds
70088view17:52, 12 July 2013MaintBotModified title
70087view17:52, 12 July 2013MaintBotupdating to 2013 schema
59082view21:58, 21 February 2013MaintBotUpdated Ensembl data source
53519view12:41, 8 November 2012Andra
53518view12:40, 8 November 2012Andra
45378view21:35, 7 October 2011KhanspersOntology Term : 'DNA repair pathway' added !
44909view10:27, 6 October 2011MartijnVanIerselOntology Term : 'miRNA pathway' added !
41207view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
37867view17:22, 13 July 2010KhanspersModified categories
37421view14:16, 1 June 2010J.krumeichSpecify description
37420view14:10, 1 June 2010J.krumeichPeriodical save, work in progress
37417view13:42, 1 June 2010J.krumeichModified description
37416view13:35, 1 June 2010J.krumeichSpecify description
37415view13:29, 1 June 2010J.krumeichSpecify description
37414view13:24, 1 June 2010J.krumeichSpecify description
37413view13:19, 1 June 2010J.krumeichPeriodical save, work in progress
37412view13:09, 1 June 2010J.krumeichPeriodical save, work in progress
37411view12:58, 1 June 2010J.krumeichPeriodical save, work in progress
37410view12:28, 1 June 2010J.krumeichPeriodical save, work in progress
37409view12:18, 1 June 2010J.krumeichPeriodical save, work in progress
37408view12:07, 1 June 2010J.krumeichPeriodical save, work in progress
37403view11:44, 1 June 2010J.krumeichSpecify description
37400view11:37, 1 June 2010J.krumeichPeriodical save, work in progress
37398view11:16, 1 June 2010J.krumeichPeriodical save, work in progress
37384view13:13, 31 May 2010J.krumeichSpecify description
37383view13:10, 31 May 2010J.krumeichSpecify description
37382view13:08, 31 May 2010J.krumeichPeriodical save, work in progress
37381view12:57, 31 May 2010J.krumeichPeriodical save, work in progress
37380view12:47, 31 May 2010J.krumeichPeriodical save, work in progress
37379view12:37, 31 May 2010J.krumeichPeriodical save, work in progress
37378view12:26, 31 May 2010J.krumeichPeriodical save, work in progress
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37376view12:06, 31 May 2010J.krumeichPeriodical save, work in progress
37375view11:55, 31 May 2010J.krumeichPeriodical save, work in progress
37374view11:45, 31 May 2010J.krumeichPeriodical save, work in progress
37373view11:38, 31 May 2010J.krumeichSpecify description
37372view10:22, 31 May 2010J.krumeichPeriodical save, work in progress
37371view10:02, 31 May 2010J.krumeichSpecify description
37370view09:55, 31 May 2010J.krumeichSpecify description
37369view09:52, 31 May 2010J.krumeichPeriodical save, work in progress
37368view09:46, 31 May 2010J.krumeichalle mirs

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ATMGeneProduct472 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CDC25A2GeneProduct993 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
H2AFXGeneProduct3014 (Entrez Gene)
RAD52GeneProduct5893 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
c-MycGeneProduct4609 (Entrez Gene)
has-let-7a-2/100 clusterGeneProduct
has-miR-195/497 clusterGeneProduct
has-mir-181a-1/181b-1 clusterGeneProduct
has-mir-181a-2/181b-2 clusterGeneProduct
hsa-let-7a-1/7d clusterGeneProduct
hsa-let-7a-3/7b clusterGeneProduct
hsa-let-7aGeneProductENSG00000199165 (Ensembl)
hsa-let-7bGeneProductENSG00000207875 (Ensembl)
hsa-let-7dGeneProductENSG00000199133 (Ensembl)
hsa-let-7fGeneProductENSG00000199072 (Ensembl)
hsa-miR-106b/25 clusterGeneProduct
hsa-miR-17/92a-1 clusterGeneProduct
hsa-miR-203 geneGeneProduct
hsa-miR-210 geneGeneProduct
hsa-miR-21geneGeneProduct
hsa-miR-222/221 clusterGeneProduct
hsa-miR-223 geneGeneProduct
hsa-miR-29b-1/29a clusterGeneProduct
hsa-miR-29b-2/29c clusterGeneProduct
hsa-miR-330 geneGeneProduct
hsa-miR-424/450b clusterGeneProduct
hsa-miR-449c/449a clusterGeneProduct
hsa-mir-100GeneProductENSG00000207994 (Ensembl)
hsa-mir-106bGeneProductENSG00000208036 (Ensembl)
hsa-mir-143/145 clusterGeneProduct
hsa-mir-143GeneProductENSG00000208035 (Ensembl)
hsa-mir-145GeneProductENSG00000207700 (Ensembl)
hsa-mir-15a/16-1 clusterGeneProduct
hsa-mir-15aGeneProductENSG00000207718 (Ensembl)
hsa-mir-15b/16-2 clusterGeneProduct
hsa-mir-15bGeneProductENSG00000207779 (Ensembl)
hsa-mir-16GeneProductENSG00000208006 (Ensembl)
hsa-mir-17GeneProductENSG00000207745 (Ensembl)
hsa-mir-181aGeneProductENSG00000207759 (Ensembl)
hsa-mir-181bGeneProductENSG00000207975 (Ensembl)
hsa-mir-18aGeneProductENSG00000199180 (Ensembl)
hsa-mir-195GeneProductENSG00000207929 (Ensembl)
hsa-mir-19aGeneProductENSG00000207610 (Ensembl)
hsa-mir-19bGeneProductENSG00000207560 (Ensembl)
hsa-mir-203GeneProductENSG00000207568 (Ensembl)
hsa-mir-20aGeneProductENSG00000199149 (Ensembl)
hsa-mir-210GeneProductENSG00000199038 (Ensembl)
hsa-mir-21GeneProductENSG00000199004 (Ensembl)
hsa-mir-221GeneProductENSG00000207870 (Ensembl)
hsa-mir-222GeneProductENSG00000207725 (Ensembl)
hsa-mir-223GeneProductENSG00000207939 (Ensembl)
hsa-mir-23a/24-2 clusterGeneProduct
hsa-mir-23aGeneProductENSG00000207980 (Ensembl)
hsa-mir-23b/24-1 clusterGeneProduct
hsa-mir-23bGeneProductENSG00000207563 (Ensembl)
hsa-mir-24GeneProductENSG00000207617 (Ensembl)
hsa-mir-25GeneProductENSG00000207547 (Ensembl)
hsa-mir-27aGeneProductENSG00000207808 (Ensembl)
hsa-mir-27bGeneProductENSG00000207864 (Ensembl)
hsa-mir-29aGeneProductENSG00000198981 (Ensembl)
hsa-mir-29bGeneProductENSG00000207748 (Ensembl)
hsa-mir-29cGeneProductENSG00000207966 (Ensembl)
hsa-mir-3074GeneProductMI0014181 (miRBase Sequence)
hsa-mir-330GeneProductENSG00000199066 (Ensembl)
hsa-mir-34b/34c clusterGeneProduct
hsa-mir-34bGeneProductENSG00000207811 (Ensembl)
hsa-mir-34cGeneProductENSG00000207562 (Ensembl)
hsa-mir-371/373 clusterGeneProduct
hsa-mir-371GeneProductENSG00000199031 (Ensembl)
hsa-mir-372GeneProductENSG00000199095 (Ensembl)
hsa-mir-373GeneProductENSG00000199143 (Ensembl)
hsa-mir-374b/421 clusterGeneProduct
hsa-mir-374bGeneProductENSG00000212027 (Ensembl)
hsa-mir-421GeneProductENSG00000202566 (Ensembl)
hsa-mir-424GeneProductENSG00000199097 (Ensembl)
hsa-mir-449aGeneProductENSG00000198983 (Ensembl)
hsa-mir-449bGeneProductENSG00000207728 (Ensembl)
hsa-mir-449cGeneProductMI0003823 (miRBase Sequence)
hsa-mir-450aGeneProductENSG00000207755 (Ensembl)
hsa-mir-450bGeneProductENSG00000216001 (Ensembl)
hsa-mir-497GeneProductENSG00000207791 (Ensembl)
hsa-mir-503GeneProductENSG00000208005 (Ensembl)
hsa-mir-542GeneProductENSG00000207784 (Ensembl)
hsa-mir-92aGeneProductENSG00000207968 (Ensembl)
hsa-mir-93GeneProductENSG00000207757 (Ensembl)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1545"
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