BDNF signaling pathway (Homo sapiens)

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VAV3MAPK9PCDK5R1SHC2MAPK8PMAPK3Y204T202γ-secretasecomplexCa2+ELMOEndocytosis-dependentOxidativeneuronalnecrosisBrain-derived neurotrophic factor signaling pathwaymembraneboundDegradationSelectivepostsynapticdevelopmentNeuriteoutgrowthReduction inphosphorylationLamellipodia formationand increasedneurite outgrowthSynaptic plasticityDissociationProteinsynthesisBCL2L11CYFIP1NCK1NCK2SHC1PPLCG1Y783PTPN11PCDH2TRAF6CTNNB1Y654SQSTM1FYNY420SHC3PNGFRNCAM1Y734TIAM1Y829LINGO1RANBP9DOK5PSHC4PGRB2SIRPAPKCNA3PFRS2PGRIN2BPFRS3PDOCK3PNTRK1PRAC1CDKL5PSORT1NGFBDNFGRIA2CREB1S133NSFGNB2L1GABRB3S432S433PPP2CACRTC1KSR1MAP2K2PMAPK1T185Y187MAP2K1PSH2B2PFOXO3S253T32MTORS2448KIDINS220PRPS6KB1T444S447T412EIF4EBP1T46T37AKT1S473T308BADS99S75SH2BPGSK3BS9GRIN1PIRS2PMAPK7T219Y221IRS1PTSC2T1462GRIA1PCAMK4PCAMK2PEEF2ACACBS78PRKAA2T172MAPTS195S202S198ELK1PIGF2BP1Y396PTK2BY402RAF1S338VAV2Y172CDK5Y15NFATC4NCF2NCF1NFATC4CYNUCYNUSTAT5BCDC42CNR1NTRK3PIK3R1NTF3BDNFPDPK1S241MAP3K1ADAM17MAPK10PHRASGTPRPS6S235S244S240S236EIF4EPPIK3R2IP3SRCFOXO3PIP2DAGSTAT5ANFKB1RELAS529NFKB1IKKRELAS529NFKBIAS36S32JUNPCASP3ProteinReceptorProteinProteinmRNASmall moleculeLigandInduced activationEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationPTM stateProtein-protein interactionDephosphorylationLEGENDPhosphorylationNucleusCytoplasmPlasma membraneCYPMNUProteolytic cleavageMoleculeCalcificationNeuronal growth,differentiation,and protectionInhibition ofapoptosisNitric oxideproductionApoptosisInhibition ofapoptosisRPS6KA3S227S386YBX1S102RPS6KA1S380S221RPS6KA5PCAMK1T177MAPK14T180Y182RASGRF1DPYSL2T514APCPTPRFDLG1GRIP1GRIA3RHOGPAKKCNN2PCFL1PBDNFBDNFPIP2PIP3PIK3CACalmodulinSOSCAMKKCalcineurinPRKAA1T196EnhancedfatoxidationReduction in FOXO3 shuttleto nucleus anddecrease in BIMMAP2K5MAP3K2MEF2CMEF2ACerebellargranuleneuronalsurvivalCYNURAP1AMAPK7T219Y221CYNURegulation of surface expression of AMPA receptorsPKCRegulation ofsynaptic plasticitySTAT5BSTAT5AGrowthconemotilityCYNURegulation of Pre-synapticplasticity CYNUCYNUHuman airwaysmooth muscle cellproliferationRelease of RNG105from RNA granulesJAK2PSTAT1STAT3PPMajor pelvicganglia neuriteoutgrowthCEBPBFOSEGR1EGR2Cortical dendrite differentiationMARCKSPPRKCDY311CDK5dependentregulation of CDC42activityRadial migrationof corticalneuronsNTRK2S495Y722NTRK2K811Y723In secretorygranulesROSGSK3BS9MicrotubuleassemblyCSNK2A1RAB3AGTPcAMPPKASPP1ALPLBMP2EIF2S1EIF2S2MAPK3T202Y204MAPK1T185Y187SYN1PNeurotransmitterreleasemembranebound


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CompareRevisionActionTimeUserComment
61132view09:24, 4 April 2013NetPathDeleted pathway: Wrong GPML
61131view09:23, 4 April 2013NetPathNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACACBProtein32 (Entrez Gene)
ADAM17Protein6868 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
ALPLRna249 (Entrez Gene)
APCProtein324 (Entrez Gene)
BADProtein572 (Entrez Gene)
BCL2L11Rna10018 (Entrez Gene)
BDNFProtein627 (Entrez Gene)
BMP2Rna650 (Entrez Gene)
CAMK1Protein8536 (Entrez Gene)
CAMK2Protein815 (Entrez Gene)
CAMK4Protein814 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CDC42Protein998 (Entrez Gene)
CDH2Protein1000 (Entrez Gene)
CDK5Protein1020 (Entrez Gene)
CDK5R1Protein8851 (Entrez Gene)
CDKL5Protein6792 (Entrez Gene)
CEBPBProtein1385 (Entrez Gene)
CFL1Protein1072 (Entrez Gene)
CNR1Protein1268 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CRTC1Protein23373 (Entrez Gene)
CSNK2A1Protein1457 (Entrez Gene)
CTNNB1Protein1499 (Entrez Gene)
CYFIP1GeneProduct23191 (Entrez Gene)
DAGMetabolite
DLG1Protein1739 (Entrez Gene)
DOCK3Protein1795 (Entrez Gene)
DOK5Protein55816 (Entrez Gene)
DPYSL2Protein1808 (Entrez Gene)
EEF2Protein1938 (Entrez Gene)
EGR1Rna1958 (Entrez Gene)
EGR2Rna1959 (Entrez Gene)
EIF2S1Protein1965 (Entrez Gene)
EIF2S2Protein8894 (Entrez Gene)
EIF4EProtein1977 (Entrez Gene)
EIF4EBP1Protein1978 (Entrez Gene)
ELK1Protein2002 (Entrez Gene)
FOSRna2353 (Entrez Gene)
FOXO3Protein2309 (Entrez Gene)
FRS2Protein10818 (Entrez Gene)
FRS3Protein10817 (Entrez Gene)
FYNProtein2534 (Entrez Gene)
GABRB3Protein2562 (Entrez Gene)
GNB2L1Protein10399 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
GRIA1Protein2890 (Entrez Gene)
GRIA2Protein2891 (Entrez Gene)
GRIA3Protein2892 (Entrez Gene)
GRIN1Protein2902 (Entrez Gene)
GRIN2BProtein2904 (Entrez Gene)
GRIP1Protein23426 (Entrez Gene)
GSK3BProtein2932 (Entrez Gene)
HRASProtein3265 (Entrez Gene)
IGF2BP1Protein10642 (Entrez Gene)
IKKProtein
IP3Protein
IRS1Protein3667 (Entrez Gene)
IRS2Protein8660 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
KCNA3Protein3738 (Entrez Gene)
KCNN2Protein3781 (Entrez Gene)
KIDINS220Protein57498 (Entrez Gene)
KSR1Protein8844 (Entrez Gene)
LINGO1Protein84894 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAP2K5Protein5607 (Entrez Gene)
MAP3K1Protein4214 (Entrez Gene)
MAP3K2Protein10746 (Entrez Gene)
MAPK10Protein5602 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK7Protein5598 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MAPTProtein4137 (Entrez Gene)
MARCKSProtein4082 (Entrez Gene)
MEF2AProtein4205 (Entrez Gene)
MEF2CProtein4208 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
NCAM1Protein4684 (Entrez Gene)
NCF1Protein4687 (Entrez Gene)
NCF2Protein4688 (Entrez Gene)
NCK1Protein4690 (Entrez Gene)
NCK2Protein8440 (Entrez Gene)
NFATC4Protein4776 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
NGFProtein4803 (Entrez Gene)
NGFRProtein4804 (Entrez Gene)
NSFProtein4905 (Entrez Gene)
NTF3Protein4908 (Entrez Gene)
NTRK1Protein4914 (Entrez Gene)
NTRK2Protein4915 (Entrez Gene)
NTRK3Protein4916 (Entrez Gene)
PDPK1Protein5170 (Entrez Gene)
PIK3CAProtein5296 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PIP2Metabolite
PIP3Metabolite
PLCG1Protein5335 (Entrez Gene)
PPP2CAProtein5515 (Entrez Gene)
PRKAA1Protein5562 (Entrez Gene)
PRKAA2Protein5563 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PTPRFProtein5792 (Entrez Gene)
RAB3AProtein5864 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RANBP9Protein10048 (Entrez Gene)
RAP1AProtein5906 (Entrez Gene)
RASGRF1Protein5923 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RHOGProtein391 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KA1Protein6195 (Entrez Gene)
RPS6KA3Protein6197 (Entrez Gene)
RPS6KA5Protein9252 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
SH2B2Protein10603 (Entrez Gene)
SH2BProtein25970 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SHC2Protein25759 (Entrez Gene)
SHC3Protein53358 (Entrez Gene)
SHC4Protein399694 (Entrez Gene)
SIRPAProtein140885 (Entrez Gene)
SORT1Protein6272 (Entrez Gene)
SPP1Rna6696 (Entrez Gene)
SQSTM1Protein8878 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
SYN1Protein6853 (Entrez Gene)
TIAM1Protein7074 (Entrez Gene)
TRAF6Protein7189 (Entrez Gene)
TSC2Protein7249 (Entrez Gene)
VAV2Protein7410 (Entrez Gene)
VAV3Protein10451 (Entrez Gene)
YBX1Protein4904 (Entrez Gene)
cAMPMetabolite

Annotated Interactions

No annotated interactions

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