MAPK cascade (Bos taurus)

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Growth and Mitogenesisp38 MAPK PathwayGiNucleusGb and GgGqStress Activated PathwaysApoptosisActivatedRap1GAPELK1MBPGTPMAP3K1GDPKRASRAF1MAP3K3PLCB3MAP2K7MAP2K4MAP3K2MAP3K12JUNBRAFRapGAPIIMAP2K3MAPK1MAP2K2MAPK10SIPA1NRASHRASRASA3MAPK3MAP2K4MAP2K1RRASMAPK14MAP2K6MAP2ARAFMAPK12


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP422(r21570) with a 84% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  2. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120345view07:25, 27 November 2021EgonwMade a pathway clickable
116824view10:17, 14 May 2021EweitzModified title
95769view14:24, 19 January 2018MkutmonHomology conversion update
86847view14:54, 13 July 2016MkutmonOntology Term : 'mitogen activated protein kinase signaling pathway' added !
86841view13:33, 13 July 2016Mkutmonontology tag fix
80699view15:22, 30 June 2015Mkutmonhomology conversion
71415view19:01, 17 October 2013MaintBotAutomated update of data sources
63370view23:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
62705view23:17, 1 May 2013MaintBotUpdated UniProt data source
40542view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33783view00:10, 9 December 2009MaintBotAutomatic update of empty xrefs
32488view12:45, 17 August 2009MaintBotFixed text labels
32183view12:32, 15 August 2009MaintBotFixed text labels
31654view11:37, 14 August 2009MaintBotFixed group labels
31186view19:28, 13 August 2009MaintBotFixed text labels
30578view22:08, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARAFGeneProduct540421 (Entrez Gene)
BRAFGeneProduct536051 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
GDPMetabolite
GTPMetabolite
HRASGeneProduct513012 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
KRASGeneProduct541140 (Entrez Gene)
MAP2GeneProduct281294 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAP2K3GeneProduct516039 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP2K6GeneProduct286883 (Entrez Gene)
MAP2K7GeneProduct787278 (Entrez Gene)
MAP3K12GeneProduct505427 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAP3K2GeneProduct504592 (Entrez Gene)
MAP3K3GeneProduct508943 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
MAPK12GeneProduct512943 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MBPGeneProduct618684 (Entrez Gene)
NRASGeneProduct506322 (Entrez Gene)
PLCB3GeneProduct515669 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RASA3GeneProduct282532 (Entrez Gene)
RRASGeneProduct616503 (Entrez Gene)
RapGAPIIGeneProduct
SIPA1GeneProduct508234 (Entrez Gene) not confirmed SwissProt ID - mu: SPA1 MOUSE

Annotated Interactions

No annotated interactions
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