mapk cascade (Danio rerio)
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p38 MAPK Pathway
Stress Activated Pathways
Activated
Rap1GAP
Apoptosis
Gq
Gi
Gb and Gg
Growth and Mitogenesis
Nucleus
zgc:113974
mapk1
GDP
braf
RapGAPII
rras
kras
GTP
LOC558321
LOC567895
LOC560913
LOC564899
jun
SIPA1
zgc:194486
zgc:92074
MAPK12
mapk14a
mapk3
map2k1
zgc:194486
HRAS
LOC556983
plcb3
zgc:172250
MAP2K3
map3k3
nras
map2k6
mapk10
sb:cb183
raf1
map3k12
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP422(r21570)
with a 78% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008
PubMed
Europe PMC
Scholia
Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
116826
view
10:19, 14 May 2021
Eweitz
Modified title
95770
view
14:24, 19 January 2018
Mkutmon
Homology conversion update
86983
view
14:32, 15 July 2016
Mkutmon
Ontology Term : 'mitogen activated protein kinase signaling pathway' added !
68640
view
04:54, 6 July 2013
MaintBot
Updated to 2013 gpml schema
62804
view
17:46, 2 May 2013
Mkutmon
remove datasource annotations without identifier
62786
view
16:32, 2 May 2013
MaintBot
Updated UniProt data source
40808
view
22:17, 1 March 2011
MaintBot
Removed redundant pathway information and comments
34197
view
21:27, 9 December 2009
MaintBot
Automatic update of empty xrefs
32325
view
13:27, 15 August 2009
MaintBot
Fixed text labels
31931
view
12:55, 14 August 2009
MaintBot
Fixed group labels
31360
view
20:33, 13 August 2009
MaintBot
Fixed text labels
31053
view
01:23, 30 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
GDP
Metabolite
GTP
Metabolite
HRAS
GeneProduct
550286 (Entrez Gene)
LOC556983
GeneProduct
556983 (Entrez Gene)
LOC558321
GeneProduct
558321 (Entrez Gene)
LOC560913
GeneProduct
560913 (Entrez Gene)
LOC564899
GeneProduct
564899 (Entrez Gene)
LOC567895
GeneProduct
567895 (Entrez Gene)
MAP2K3
GeneProduct
MAPK12
GeneProduct
30681 (Entrez Gene)
RapGAPII
GeneProduct
SIPA1
GeneProduct
not confirmed SwissProt ID - mu: SPA1 MOUSE
braf
GeneProduct
403065 (Entrez Gene)
jun
GeneProduct
335916 (Entrez Gene)
kras
GeneProduct
445289 (Entrez Gene)
map2k1
GeneProduct
406728 (Entrez Gene)
map2k6
GeneProduct
65239 (Entrez Gene)
map3k12
GeneProduct
404626 (Entrez Gene)
map3k3
GeneProduct
560211 (Entrez Gene)
mapk10
GeneProduct
569698 (Entrez Gene)
mapk1
GeneProduct
360144 (Entrez Gene)
mapk14a
GeneProduct
65237 (Entrez Gene)
mapk3
GeneProduct
399480 (Entrez Gene)
nras
GeneProduct
30380 (Entrez Gene)
plcb3
GeneProduct
100001532 (Entrez Gene)
raf1
GeneProduct
30716 (Entrez Gene)
rras
GeneProduct
449660 (Entrez Gene)
sb:cb183
GeneProduct
368319 (Entrez Gene)
zgc:113974
GeneProduct
555420 (Entrez Gene)
zgc:172250
GeneProduct
100002225 (Entrez Gene)
zgc:194486
GeneProduct
568951 (Entrez Gene)
zgc:92074
GeneProduct
403063 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Discussion
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions