Test (Bos taurus)

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2pApoptosiseDegradationFas LigandInhibitor of Cell DeathbIGF1R signaling pathwayActivator of Cell DeathInterferon regulatory factorsbeDNA Fragmentationbp53 RelatedMitochondrionpCaspPRF1BADAKT1RIPK1BIRC5BCL2L1BAK1MAPK10PIK3R1BNIP3LTNFRSF21CHUKNFKBIAHRKTRAF3IRF2NFKBIENFKB1DFFBBIRC3NFKBIBBOKNFKBIABAXCFLARBIRC2MDM2RELATNFSF10HELLSCASP7NFKBIETNFTRAF1TP63JUNIGF1BCL2IRF7MCL1TP53LTAIRF6IKBKBFASLGTNFRSF1ANFKBIBCASP11BIDTP73CYCTIKBKGNFKB1BCL2L2TNFRSF25TRADDCASP10MAP2K4CASP8IRF5RIPK1CASP9PMAIP1CYCSAPAF1BBC3TNFRSF10BBCL2L11TRAF2DIABLODFFAXIAPCRADDMYCCASP1FADDCASP3CDKN2AFASIRF4RELAIRF3CASP6IGF2CASP2IGF1RTNFRSF1BTRADDBADMAP3K1TNFRSF1AGZMBIRF1CASP41


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP254(r41184) with a 88% conversion rate.

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Bibliography


History

CompareRevisionActionTimeUserComment
63307view20:54, 9 May 2013MaintBotDeleted pathway: test
63302view20:41, 9 May 2013MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
APAF1GeneProduct537782 (Entrez Gene)
BADGeneProduct615013 (Entrez Gene)
BAK1GeneProduct514090 (Entrez Gene)
BAXGeneProduct280730 (Entrez Gene)
BBC3GeneProduct
BCL2GeneProduct281020 (Entrez Gene)
BCL2L11GeneProduct
BCL2L1GeneProduct282152 (Entrez Gene)
BCL2L2GeneProduct767601 (Entrez Gene)
BIDGeneProduct510373 (Entrez Gene)
BIRC2GeneProduct
BIRC3GeneProduct514386 (Entrez Gene)
BIRC5GeneProduct414925 (Entrez Gene)
BNIP3LGeneProduct534615 (Entrez Gene)
BOKGeneProduct504851 (Entrez Gene)
CASP10GeneProduct
CASP11GeneProduct
CASP1GeneProduct514214 (Entrez Gene)
CASP2GeneProduct531419 (Entrez Gene)
CASP3GeneProduct408016 (Entrez Gene)
CASP4GeneProduct338039 (Entrez Gene)
CASP6GeneProduct538409 (Entrez Gene)
CASP7GeneProduct526279 (Entrez Gene)
CASP8GeneProduct507481 (Entrez Gene)
CASP9GeneProduct100140945 (Entrez Gene)
CDKN2AGeneProduct
CFLARGeneProduct497199 (Entrez Gene)
CHUKGeneProduct281073 (Entrez Gene)
CRADDGeneProduct
CYCSGeneProduct
CYCTGeneProduct
DFFAGeneProduct507981 (Entrez Gene)
DFFBGeneProduct512730 (Entrez Gene)
DIABLOGeneProduct493999 (Entrez Gene)
FADDGeneProduct493720 (Entrez Gene)
FASGeneProduct282488 (Entrez Gene)
FASLGGeneProduct407111 (Entrez Gene)
GZMBGeneProduct508646 (Entrez Gene)
HELLSGeneProduct540933 (Entrez Gene)
HRKGeneProduct787139 (Entrez Gene)
IGF1GeneProduct281239 (Entrez Gene)
IGF1RGeneProduct281848 (Entrez Gene)
IGF2GeneProduct281240 (Entrez Gene)
IKBKBGeneProduct281854 (Entrez Gene)
IKBKGGeneProduct281855 (Entrez Gene)
IRF1GeneProduct789216 (Entrez Gene)
IRF2GeneProduct337916 (Entrez Gene)
IRF3GeneProduct516979 (Entrez Gene)
IRF4GeneProduct506141 (Entrez Gene)
IRF5GeneProduct615340 (Entrez Gene)
IRF6GeneProduct614253 (Entrez Gene)
IRF7GeneProduct100125591 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
LTAGeneProduct280845 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
MCL1GeneProduct788087 (Entrez Gene)
MDM2GeneProduct540378 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
NFKBIAGeneProduct282291 (Entrez Gene)
NFKBIBGeneProduct525408 (Entrez Gene)
NFKBIEGeneProduct506727 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PMAIP1GeneProduct
PRF1GeneProduct369025 (Entrez Gene)
RELAGeneProduct508233 (Entrez Gene)
RIPK1GeneProduct504727 (Entrez Gene)
TNFGeneProduct280943 (Entrez Gene)
TNFRSF10BGeneProduct
TNFRSF1AGeneProduct282527 (Entrez Gene)
TNFRSF1BGeneProduct338033 (Entrez Gene)
TNFRSF21GeneProduct537922 (Entrez Gene)
TNFRSF25GeneProduct783432 (Entrez Gene)
TNFSF10GeneProduct507215 (Entrez Gene)
TP53GeneProduct281542 (Entrez Gene)
TP63GeneProduct615335 (Entrez Gene)
TP73GeneProduct515105 (Entrez Gene)
TRADDGeneProduct504707 (Entrez Gene)
TRAF1GeneProduct540944 (Entrez Gene)
TRAF2GeneProduct512355 (Entrez Gene)
TRAF3GeneProduct506182 (Entrez Gene)
XIAPGeneProduct281647 (Entrez Gene)

Annotated Interactions

No annotated interactions
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