IL-2 signaling pathway (Bos taurus)

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DPMProteins in a complex interactionCYReceptorEREnzyme complexGolgi apparatusDMT(Protein-protein interaction)CytoplasmDTranslocationAcetylationCY -> NUEndoplasmic reticulumDNucleusDLigandPhosphorylationCY -> NUActivationENCY -> NUMolecular associationGOCY -> NUDNucleusCY -> NUDesumoylationCY -> PMNUDephosphorylationDemethylationPM -> CYProteolytic cleavageDSumoylationControlECGene SymbolReactions through unknown mechanisms/moleculesDPhosphorylationAutophosphorylationEndosomeInhibitionCY -> NUMethylationDUbiquitinationMolecule in the pathwayCY -> NUAccession Number: NetPath 14NUMTExtracellularRecruitmentCY -> NUPalmitolyationDeubiquitinationGlycosylationDDeacetylationDPlasma membraneMitochondrionDEIF3BRAF1CRKLOC100139219JAK2NFKB1GRB2ETS2GAB2CBLSTAM2AKT1IRS1RELAIL2IL2IL2RGPIK3CGMAPK1TERTSOCS1STAT5BSTAT5BAKT1MAPK8HSPCASTAMPTK2BGNB2L1CHUKMAPKAPK2ETS1STAT1TERTPIK3R2IL2CISHMAP2K2KRASPTPN6VAV1PIK3CASOCS3JAK3YBX1STAT5ASHBMAPK3FOXO3IRS2BCL2IL2RAPLCB1RAF1ITM2BEIF4ELYNIL2IL2RBAKT1MKNK1MAPK9SYKNR3C1NMIIFNA1MAP2K1RPS6KB1PRKCZPIK3CBCD53PTPN11IL2SHC1JAK1PIK3CDSOS1STAT3RELACRKLSTAT5AICAM1PIK3R1MAPK3MAPK14LCKFYNCRKCREB1YBX1NFKB1MAPK1


Description

Interleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a common gamma chain (γc), which is shared by all members of this family of cytokines. Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_14

Comments

GenMAPP notes 
NetPath 14 - IL-2 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 93% conversion rate.

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117543view11:15, 21 May 2021EweitzModified title
115938view08:13, 21 March 2021EgonwCopied the NetPath paper into the literature list
115933view08:08, 21 March 2021EgonwModified description
89827view12:04, 6 October 2016MkutmonModified description
80912view15:31, 30 June 2015Mkutmonhomology conversion
67373view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
63312view21:01, 9 May 2013MaintBotupdating gpml
40493view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35784view06:21, 13 February 2010MaintBotAdded description
33737view23:54, 8 December 2009MaintBotAutomatic update of empty xrefs
31632view22:22, 13 August 2009MaintBotFixed text labels
30542view21:56, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
BCL2GeneProduct281020 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CD53GeneProduct505040 (Entrez Gene)
CHUKGeneProduct281073 (Entrez Gene)
CISHGeneProduct616753 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CRKLGeneProduct
EIF3BGeneProduct789999 (Entrez Gene)
EIF4EGeneProduct281751 (Entrez Gene)
ETS1GeneProduct540313 (Entrez Gene)
ETS2GeneProduct281148 (Entrez Gene)
FOXO3GeneProduct535530 (Entrez Gene)
FYNGeneProduct527263 (Entrez Gene)
GAB2GeneProduct529346 (Entrez Gene)
GNB2L1GeneProduct327682 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
HSPCAGeneProduct281832 (Entrez Gene)
ICAM1GeneProduct281839 (Entrez Gene)
IFNA1GeneProduct281843 (Entrez Gene)
IL2GeneProduct280822 (Entrez Gene)
IL2RAGeneProduct281861 (Entrez Gene)
IL2RBGeneProduct510185 (Entrez Gene)
IL2RGGeneProduct281862 (Entrez Gene)
IRS1GeneProduct538598 (Entrez Gene)
IRS2GeneProduct
ITM2BGeneProduct510575 (Entrez Gene)
JAK1GeneProduct537201 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
JAK3GeneProduct
KRASGeneProduct541140 (Entrez Gene)
LCKGeneProduct508890 (Entrez Gene)
LOC100139219GeneProduct100139219 (Entrez Gene)
LYNGeneProduct534996 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MAPKAPK2GeneProduct788091 (Entrez Gene)
MKNK1GeneProduct525647 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
NMIGeneProduct784981 (Entrez Gene)
NR3C1GeneProduct281946 (Entrez Gene)
PIK3CAGeneProduct282306 (Entrez Gene)
PIK3CBGeneProduct517948 (Entrez Gene)
PIK3CDGeneProduct504531 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PLCB1GeneProduct287026 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PTK2BGeneProduct541008 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN6GeneProduct512312 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RELAGeneProduct508233 (Entrez Gene)
RPS6KB1GeneProduct404181 (Entrez Gene)
SHBGeneProduct538275 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SOCS1GeneProduct518795 (Entrez Gene)
SOCS3GeneProduct282081 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
STAM2GeneProduct538505 (Entrez Gene)
STAMGeneProduct512734 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)
SYKGeneProduct515515 (Entrez Gene)
TERTGeneProduct518884 (Entrez Gene)
VAV1GeneProduct617345 (Entrez Gene)
YBX1GeneProduct287023 (Entrez Gene)

Annotated Interactions

No annotated interactions
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