Oxidative stress response (Bos taurus)
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TF activation
Reactive Oxygen Species
Repression
TF inhibition
Repression of ROS-
producing systems
Inhibition of oxidases
Immediate-early
gene induction
Activation
Induction of
antioxidant genes
Adaptive response
Stress-regulated MAP kinase
HMOX1
TXNRD2
XDH
TXN2
GPX1
SOD1
NFKB1
CYBA
GSR
TXNRD1
SP1
GPX3
JUNB
Nrf2
MAOA
NFIX
MAPK10
NQO1
FOS
SOD3
SOD2
CAT
CYP1A1
MGST1
MAPK14
GSTT2
MT1X
UGT1A6
GCLC
Description
No description
Comments
GenMAPP notes
Adapted from Biochem J 1999 Sep 15;342 Pt 3:481-96 Morel Y, Barouki R. Repression of gene expression by oxidative stress. Biochem J 1999 Sep 15;342 Pt 3:481-96
GenMAPP remarks
Adapted from rat by GenMAPP.org
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP408(r21540)
with a 86% conversion rate.
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Bibliography
Morel Y, Barouki R; ''Repression of gene expression by oxidative stress.''; Biochem J, 1999
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
117036
view
14:11, 16 May 2021
Eweitz
Modified title
80921
view
15:31, 30 June 2015
Mkutmon
homology conversion
71403
view
19:00, 17 October 2013
MaintBot
Automated update of data sources
63336
view
21:13, 9 May 2013
MaintBot
Updated to 2013 gpml schema
40516
view
19:29, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33759
view
00:02, 9 December 2009
MaintBot
Automatic update of empty xrefs
32514
view
12:53, 17 August 2009
MaintBot
Fixed text labels
32202
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12:38, 15 August 2009
MaintBot
Fixed text labels
31685
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11:45, 14 August 2009
MaintBot
Fixed group labels
31212
view
19:37, 13 August 2009
MaintBot
Fixed text labels
30619
view
22:22, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
CAT
GeneProduct
531682 (Entrez Gene)
CYBA
GeneProduct
281111 (Entrez Gene)
Probe set ID: u18729
CYP1A1
GeneProduct
282870 (Entrez Gene)
FOS
GeneProduct
280795 (Entrez Gene)
GCLC
GeneProduct
512468 (Entrez Gene)
GPX1
GeneProduct
281209 (Entrez Gene)
GPX3
GeneProduct
281210 (Entrez Gene)
GSR
GeneProduct
506406 (Entrez Gene)
GSTT2
GeneProduct
HMOX1
GeneProduct
513221 (Entrez Gene)
JUNB
GeneProduct
514246 (Entrez Gene)
MAOA
GeneProduct
281293 (Entrez Gene)
MAPK10
GeneProduct
537631 (Entrez Gene)
MAPK14
GeneProduct
534492 (Entrez Gene)
MGST1
GeneProduct
493719 (Entrez Gene)
MT1X
GeneProduct
NFIX
GeneProduct
536348 (Entrez Gene)
NFKB1
GeneProduct
616115 (Entrez Gene)
NQO1
GeneProduct
519632 (Entrez Gene)
Nrf2
GeneProduct
SOD1
GeneProduct
507743 (Entrez Gene)
SOD2
GeneProduct
281496 (Entrez Gene)
SOD3
GeneProduct
532481 (Entrez Gene)
SP1
GeneProduct
540741 (Entrez Gene)
TXN2
GeneProduct
281557 (Entrez Gene)
TXNRD1
GeneProduct
282388 (Entrez Gene)
TXNRD2
GeneProduct
282389 (Entrez Gene)
UGT1A6
GeneProduct
286792 (Entrez Gene)
XDH
GeneProduct
280960 (Entrez Gene)
Annotated Interactions
No annotated interactions
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