ErbB signaling pathway (Bos taurus)

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+p+pActivation by ErbB2overexpression (cancers)DifferentiationPancreaticCancerAdhesionMigrationMetabolismCa+2+p+pCell cycleprogressionCell survivalPIP3DNAMAPK signalingpathwayDNA+pERCellular targetsERBB SIGNALING PATHWAY(HER2/Neu)+pGliomaEndometrialcancer+pProliferationProteinsynthesis+pDNAAdhesionmTor signaling pathwayReceptor ubiquitylationCell cycle+pDegradationIP3Non-smallcell lungcancer+p+p+p+pSurvival+p+pCellular targetsMigration / InvasionAngiogenesisDNA+p(EGFR)+p+p+pNo signalingDGCalcium signaling pathwayRPS6KB1SHC2BADNRG2PRKCANRG3TGFAHBEGFJUNPAK4NCK1LOC100137872CDKN1APLCG1CDKN1BEREGMAP2K1NRG1CAMK2AHRASERBB3BTCCRKGRB2MAP2K7ERBB2ARAFMAPK8AREGMAPK1ERBB4SRCSOS1NRG4ERBB3PIK3R5ELK1GAB1EGFRCBLCERBB4FAKERBB2MYCERBB4EGFRSTAT5ALOC100139219STAT5AERBB2ERBB3ERBB2EGFREIF4EBP1ABL1GRB2EGFGSK3BERBB2ELK1


Description

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.

The ErbB protein family consists of 4 members 

   * ErbB-1, also named epidermal growth factor receptor (EGFR)
   * ErbB-2, also named HER2 in humans and neu in rodents
   * ErbB-3, also named HER3 and
   * ErbB-4, also named HER4

The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP673(r29836) with a 73% conversion rate.

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Bibliography

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  1. Clark DE, Williams CC, Duplessis TT, Moring KL, Notwick AR, Long W, Lane WS, Beuvink I, Hynes NE, Jones FE; ''ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  2. Oda K, Matsuoka Y, Funahashi A, Kitano H; ''A comprehensive pathway map of epidermal growth factor receptor signaling.''; Mol Syst Biol, 2005 PubMed Europe PMC Scholia
  3. Hynes NE, Lane HA; ''ERBB receptors and cancer: the complexity of targeted inhibitors.''; Nat Rev Cancer, 2005 PubMed Europe PMC Scholia
  4. Muthuswamy SK, Gilman M, Brugge JS; ''Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers.''; Mol Cell Biol, 1999 PubMed Europe PMC Scholia
  5. Schulze WX, Deng L, Mann M; ''Phosphotyrosine interactome of the ErbB-receptor kinase family.''; Mol Syst Biol, 2005 PubMed Europe PMC Scholia
  6. Scaltriti M, Baselga J; ''The epidermal growth factor receptor pathway: a model for targeted therapy.''; Clin Cancer Res, 2006 PubMed Europe PMC Scholia
  7. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT; ''Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  8. Liang J, Slingerland JM; ''Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.''; Cell Cycle, 2003 PubMed Europe PMC Scholia
  9. McCarty JH; ''The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events.''; Bioessays, 1998 PubMed Europe PMC Scholia
  10. Citri A, Yarden Y; ''EGF-ERBB signalling: towards the systems level.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  11. Marmor MD, Skaria KB, Yarden Y; ''Signal transduction and oncogenesis by ErbB/HER receptors.''; Int J Radiat Oncol Biol Phys, 2004 PubMed Europe PMC Scholia
  12. Olayioye MA, Neve RM, Lane HA, Hynes NE; ''The ErbB signaling network: receptor heterodimerization in development and cancer.''; EMBO J, 2000 PubMed Europe PMC Scholia
  13. Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F, Salomon DS; ''Epidermal growth factor receptor (EGFR) signaling in cancer.''; Gene, 2006 PubMed Europe PMC Scholia
  14. Hashimoto Y, Katayama H, Kiyokawa E, Ota S, Kurata T, Gotoh N, Otsuka N, Shibata M, Matsuda M; ''Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  15. Yarden Y, Sliwkowski MX; ''Untangling the ErbB signalling network.''; Nat Rev Mol Cell Biol, 2001 PubMed Europe PMC Scholia
  16. Holbro T, Hynes NE; ''ErbB receptors: directing key signaling networks throughout life.''; Annu Rev Pharmacol Toxicol, 2004 PubMed Europe PMC Scholia
  17. Ryan DP, Engelman JA, Ferrone CR, Sahani DV, Lisovsky M; ''Case records of the Massachusetts General Hospital. Case 19-2010. A 35-year-old man with adenocarcinoma of the cecum.''; N Engl J Med, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116520view11:01, 7 May 2021EweitzModified title
108379view10:32, 15 December 2019Marvin M2Changed dashed lines into graphical lines
108363view14:54, 12 December 2019Marvin M2Connected lines
108257view14:28, 3 December 2019L DupuisConnected unconnected lines
108169view10:48, 29 November 2019FehrhartOntology Term : 'cancer' added !
108168view10:48, 29 November 2019FehrhartOntology Term : 'multiple sclerosis' added !
108167view10:48, 29 November 2019FehrhartOntology Term : 'Alzheimer's disease' added !
106017view11:54, 16 August 2019MaintBotHMDB identifier normalization
97534view14:29, 24 May 2018Fehrhartupdated identifiers
80923view15:31, 30 June 2015Mkutmonhomology conversion
70168view00:30, 13 July 2013AlexanderPicoModified title
63390view00:03, 10 May 2013MaintBotUpdated to 2013 gpml schema
40563view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33801view00:17, 9 December 2009MaintBotAutomatic update of empty xrefs
32509view12:51, 17 August 2009MaintBotFixed text labels
31207view19:35, 13 August 2009MaintBotFixed text labels
30613view22:19, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProduct540876 (Entrez Gene)
ARAFGeneProduct540421 (Entrez Gene)
AREGGeneProduct
BADGeneProduct615013 (Entrez Gene)
BTCGeneProduct280737 (Entrez Gene)
CAMK2AGeneProduct530719 (Entrez Gene)
CBLCGeneProduct615866 (Entrez Gene)
CDKN1AGeneProduct513497 (Entrez Gene)
CDKN1BGeneProduct512613 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
EGFGeneProduct786061 (Entrez Gene)
EGFRGeneProduct407217 (Entrez Gene)
EIF4EBP1GeneProduct509613 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
ERBB2GeneProduct
ERBB3GeneProduct785655 (Entrez Gene)
ERBB4GeneProduct
EREGGeneProduct
FAKGeneProduct
GAB1GeneProduct540085 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
HBEGFGeneProduct522921 (Entrez Gene)
HRASGeneProduct513012 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
LOC100137872GeneProduct100137872 (Entrez Gene)
LOC100139219GeneProduct100139219 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K7GeneProduct787278 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
NCK1GeneProduct536154 (Entrez Gene)
NRG1GeneProduct281361 (Entrez Gene)
NRG2GeneProduct
NRG3GeneProduct539977 (Entrez Gene)
NRG4GeneProduct616763 (Entrez Gene)
PAK4GeneProduct539742 (Entrez Gene)
PIK3R5GeneProduct614838 (Entrez Gene)
PLCG1GeneProduct281987 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
RPS6KB1GeneProduct404181 (Entrez Gene)
SHC2GeneProduct533455 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SRCGeneProduct535742 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
TGFAGeneProduct540388 (Entrez Gene)

Annotated Interactions

No annotated interactions
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