FAS pathway and stress induction of HSP regulation (Bos taurus)

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1Necrosis3x-PCutDNA presentationActivateFAS PathwayMitochondria PathwayApoptosome3x-PNFK-B PathwayCytoplasmROSStress Induction of HSP regulationExtracellularStressCell SurvivalProteasomeSelf-activationInhibition3x-PNucleusCASP3CASP8FADDPhosphateDAXXCASP8PhosphateARHGDIBLMNB1FAF1CFLARMAP3K7JUNCASP7MAPKAPK3PhosphateHSPB1LMNB2FASDAXXDFFBIL1ACYCSPhosphateFAP1HSPB1CASP10PhosphateAPAF1HSPB1PARP1PhosphateFASLGGlutathioneHSPB1RIPK2HSPB1MAP2K4SPTAN1MAP3K1APAF1BCL2HSPB1HSPB1CASP9FAF1RB1PhosphateactinMAPKAPK2CASP3DFFALMNAPhosphateMAPK8DFFBHSPB1ApoptosisPRKDCPAK2CeramideTNFCASP6PAK1


Description

This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP314(r45253) with a 92% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Ji Q, Hao X, Meng Y, Zhang M, Desano J, Fan D, Xu L; ''Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres.''; BMC Cancer, 2008 PubMed Europe PMC Scholia
  2. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120928view08:04, 1 February 2022EgonwMade a pathway clickable
117075view14:44, 16 May 2021EweitzModified title
105979view11:50, 16 August 2019MaintBotHMDB identifier normalization
84563view11:32, 3 March 2016Mkutmonadded missing graph ids
80796view15:26, 30 June 2015Mkutmonhomology conversion
67219view10:22, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
63447view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
48131view05:50, 9 May 2012MaintBotUpdating from human to fix xref duplication
40581view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
38224view21:04, 27 August 2010KhanspersRemoved protein complex and receptor graphics
35556view14:59, 12 February 2010ThomasModified description
35553view14:58, 12 February 2010Thomasadded literature
33818view00:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32495view12:47, 17 August 2009MaintBotFixed text labels
32188view12:34, 15 August 2009MaintBotFixed text labels
31660view11:39, 14 August 2009MaintBotFixed group labels
31193view19:31, 13 August 2009MaintBotFixed text labels
30588view22:11, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APAF1GeneProduct537782 (Entrez Gene)
ARHGDIBGeneProduct327676 (Entrez Gene) Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
ApoptosisPathwayWP254 (WikiPathways)
BCL2GeneProduct281020 (Entrez Gene)
CASP10GeneProduct
CASP3GeneProduct408016 (Entrez Gene)
CASP6GeneProduct538409 (Entrez Gene)
CASP7GeneProduct526279 (Entrez Gene)
CASP8GeneProduct507481 (Entrez Gene)
CASP9GeneProduct100140945 (Entrez Gene)
CFLARGeneProduct497199 (Entrez Gene)
CYCSGeneProduct
CeramideMetabolite104404-17-3 (CAS)
DAXXGeneProduct504336 (Entrez Gene)
DFFAGeneProduct507981 (Entrez Gene)
DFFBGeneProduct512730 (Entrez Gene)
FADDGeneProduct493720 (Entrez Gene)
FAF1GeneProduct531770 (Entrez Gene)
FAP1GeneProduct
FASGeneProduct282488 (Entrez Gene)
FASLGGeneProduct407111 (Entrez Gene)
GlutathioneMetaboliteHMDB00125 (HMDB)
HSPB1GeneProduct516099 (Entrez Gene)
IL1AGeneProduct281250 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
LMNAGeneProduct404144 (Entrez Gene)
LMNB1GeneProduct540643 (Entrez Gene)
LMNB2GeneProduct516326 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPKAPK2GeneProduct788091 (Entrez Gene)
MAPKAPK3GeneProduct615215 (Entrez Gene)
PAK1GeneProduct533729 (Entrez Gene)
PAK2GeneProduct513673 (Entrez Gene)
PARP1GeneProduct286764 (Entrez Gene)
PRKDCGeneProduct512740 (Entrez Gene)
PhosphateMetaboliteHMDB01429 (HMDB)
RB1GeneProduct534712 (Entrez Gene)
RIPK2GeneProduct534407 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 2
SPTAN1GeneProduct540108 (Entrez Gene) Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TNFGeneProduct280943 (Entrez Gene)
actinGeneProduct

Annotated Interactions

No annotated interactions
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