B cell receptor signaling pathway (Bos taurus)

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Plasma membraneMT->CYUbiquitinationCY->NUCY->PMProteins in a complex interactionGOMTDECCY->NUAutophosphorylationNU->CYDCY->PMComplexDCY->PMDDCY->PMERPhosphorylationCY->NUSumoylationEndoplasmic reticulumMolecular associationPMDesumoylationGlycosylationNUDCY->PMEnzyme ComplexMolecule in the pathwayENExtracellularAcetylationActivationMACYDDemethylationARP2/3(Protein-protein interaction)NucleusCY->PMCY->NUPM->CYDephosphorylationProteolytic cleavageCY->NUAccesion Number: NetPath 12LigandMethylationCytoplasmDEndosomeReaction through unknown mechanisms/moleculesCY->PMTranslocationDDCY->PMCY->PMCY->NUCY->PMReceptorCY->PMDDeacetylationDDeubiquitinationCY->PMNU->CYDCY->PMControlCY->PMPalmitoylationCY->PMMitochondriaGolgi apparatusCY->PMCY->PMPM->CYInhibitionCY->PMDCY->MTDCY->NURecruitmentCY->NUDCCND3PTPN18Gene SymbolARPC2CD79ALOC100138311PIP4K2CCBLLOC100138040PLEKHA2DAPP1LYNPRKCDCBLBARPC3PIK3R1GAB2RPS6KA1PLCG1CYCSNFATC3PIP5K1ANFATC1PDK2SH3BP2SH2B2RAF1DAPP1PLEKHA2BCL10PIP5K1BMAPK8CD5PILRBRELAHDAC5ITPR1PRKCEPRKD1SHC1PPP3CBSYKGRB2RHOAPIP4K2BRASGRP3GSK3BLAT2LOC509843CDK6RAP2AITPR2PTPN6CRKSHC1LAT2PRKCQCDK2BLNKARPC4RB1NCK1CYCSPRKCDBRAFMAPKAPK2DOK1LCP2PLCG2PIP5K1CHNRNPKCRKSLA2LOC509843PIP5K1BNFATC2CD72WASPIP4K2BINPP5DRPS6NFATC3SOS1HCKTECPTPN6PRKCECRKLIKBKBLIME1SYKBLKCTNNB1CARD11MAPK4CHUKPPP3CACASP7PIP5K1Bcd21BTKPTPN11HCLS1RPS6KB1ELK1RPS6KA1GTF2IPLEKHA1FYNLOC506618ITKMAPK1BCAR1JUNHDAC5GAB1ACTR2PRKCBBCL6CD79BPLEKHA1PTPN6LCKNFKBIASTAP1FCGR2BPIK3R2RASGRP3RAPGEF1MAP2K1CMTM3CD81BTKDOK3RASA1PTK2BLYNGSK3ACCNE1AKT1ATF2CHUKIKBKBZAP70PPP3R1LYNHCLS1BAXIKBKGSTAT3LOC100138311AKT1BLNKGAB1ARPC5ACTR3ARPC1BIGHMMAP3K7MAP4K1GRB2INPP5DPIP4K2ACASP9BCL2ATP2B4CDK7NFATC2VAV1CCNA2BANK1MAP2K2HCLS1PLCG2LOC100138102CD79ARELABAXMAPK3PTPRCPRKCBBRAGMAPK14CDK4DUSP6CCND2BCL2L11STAT1RAPGEF1RELRELPIK3CGPTK2CD19PIP4K2BNEDD9CARD11GTF2IVAV2CSKCD22CTNNB1SYKCREB1DUSP4


Description

The B cell receptor includes membrane μ heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_12

Comments

GenMAPP notes 
NetPath 12 - B Cell Receptor Signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP23(r20725) with a 85% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117479view10:59, 21 May 2021EweitzModified title
115959view08:25, 22 March 2021EgonwCopied the NetPath paper into the literature list
115949view07:12, 22 March 2021EgonwModified description
89901view13:19, 6 October 2016MkutmonModified description
80807view15:26, 30 June 2015Mkutmonhomology conversion
67068view10:02, 26 June 2013Christine ChichesterOntology Term : 'B cell receptor signaling pathway' added !
63478view17:22, 10 May 2013MaintBotupdating gpml
40541view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
35705view23:14, 12 February 2010AlexanderPico
33782view00:09, 9 December 2009MaintBotAutomatic update of empty xrefs
32499view12:48, 17 August 2009MaintBotFixed text labels
31197view19:32, 13 August 2009MaintBotFixed text labels
30594view22:13, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTR2GeneProduct538486 (Entrez Gene)
ACTR3GeneProduct281597 (Entrez Gene)
AKT1GeneProduct280991 (Entrez Gene)
ARPC1BGeneProduct326600 (Entrez Gene)
ARPC2GeneProduct540838 (Entrez Gene)
ARPC3GeneProduct506596 (Entrez Gene)
ARPC4GeneProduct539459 (Entrez Gene)
ARPC5GeneProduct614345 (Entrez Gene)
ATF2GeneProduct509827 (Entrez Gene)
ATP2B4GeneProduct282146 (Entrez Gene)
BANK1GeneProduct616565 (Entrez Gene)
BAXGeneProduct785708 (Entrez Gene)
BCAR1GeneProduct527550 (Entrez Gene)
BCL10GeneProduct540824 (Entrez Gene)
BCL2GeneProduct281020 (Entrez Gene)
BCL2L11GeneProduct507390 (Entrez Gene)
BCL6GeneProduct539020 (Entrez Gene)
BLKGeneProduct532587 (Entrez Gene)
BLNKGeneProduct510393 (Entrez Gene)
BRAFGeneProduct536051 (Entrez Gene)
BRAGGeneProduct
BTKGeneProduct533459 (Entrez Gene)
CARD11GeneProduct515377 (Entrez Gene)
CASP7GeneProduct526279 (Entrez Gene)
CASP9GeneProduct100140945 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CBLBGeneProduct525906 (Entrez Gene)
CCNA2GeneProduct281667 (Entrez Gene)
CCND2GeneProduct615414 (Entrez Gene)
CCND3GeneProduct540547 (Entrez Gene)
CCNE1GeneProduct533526 (Entrez Gene)
CD19GeneProduct517359 (Entrez Gene)
CD22GeneProduct514582 (Entrez Gene)
CD5GeneProduct280745 (Entrez Gene)
CD72GeneProduct783725 (Entrez Gene)
CD79AGeneProduct281674 (Entrez Gene)
CD79BGeneProduct
CD81GeneProduct511435 (Entrez Gene)
CDK2GeneProduct519217 (Entrez Gene)
CDK4GeneProduct510618 (Entrez Gene)
CDK6GeneProduct511754 (Entrez Gene)
CDK7GeneProduct515462 (Entrez Gene)
CHUKGeneProduct281073 (Entrez Gene)
CMTM3GeneProduct787512 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CRKLGeneProduct
CSKGeneProduct509246 (Entrez Gene)
CTNNB1GeneProduct539003 (Entrez Gene)
CYCSGeneProduct510767 (Entrez Gene)
DAPP1GeneProduct533156 (Entrez Gene)
DOK1GeneProduct514962 (Entrez Gene)
DOK3GeneProduct514894 (Entrez Gene)
DUSP4GeneProduct540380 (Entrez Gene)
DUSP6GeneProduct515310 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
FCGR2BGeneProduct282229 (Entrez Gene)
FYNGeneProduct527263 (Entrez Gene)
GAB1GeneProduct540085 (Entrez Gene)
GAB2GeneProduct529346 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GSK3AGeneProduct536561 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
GTF2IGeneProduct534669 (Entrez Gene)
Gene SymbolGeneProduct
HCKGeneProduct280814 (Entrez Gene)
HCLS1GeneProduct508445 (Entrez Gene)
HDAC5GeneProduct504242 (Entrez Gene)
HNRNPKGeneProduct528135 (Entrez Gene)
IGHMGeneProduct404057 (Entrez Gene)
IKBKBGeneProduct281854 (Entrez Gene)
IKBKGGeneProduct281855 (Entrez Gene)
INPP5DGeneProduct507329 (Entrez Gene)
ITKGeneProduct522311 (Entrez Gene)
ITPR1GeneProduct317697 (Entrez Gene)
ITPR2GeneProduct281878 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
LAT2GeneProduct505016 (Entrez Gene)
LCKGeneProduct508890 (Entrez Gene)
LCP2GeneProduct513244 (Entrez Gene)
LIME1GeneProduct
LOC100138040GeneProduct100138040 (Entrez Gene)
LOC100138102GeneProduct100138102 (Entrez Gene)
LOC100138311GeneProduct100138311 (Entrez Gene)
LOC506618GeneProduct506618 (Entrez Gene)
LOC509843GeneProduct509843 (Entrez Gene)
LYNGeneProduct534996 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAP4K1GeneProduct522002 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK4GeneProduct529183 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPKAPK2GeneProduct788091 (Entrez Gene)
NCK1GeneProduct536154 (Entrez Gene)
NEDD9GeneProduct504967 (Entrez Gene)
NFATC1GeneProduct511224 (Entrez Gene)
NFATC2GeneProduct530401 (Entrez Gene)
NFATC3GeneProduct541127 (Entrez Gene)
NFKBIAGeneProduct282291 (Entrez Gene)
PDK2GeneProduct524075 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PILRBGeneProduct
PIP4K2AGeneProduct533289 (Entrez Gene)
PIP4K2BGeneProduct539211 (Entrez Gene)
PIP4K2CGeneProduct540005 (Entrez Gene)
PIP5K1AGeneProduct100125224 (Entrez Gene)
PIP5K1BGeneProduct537654 (Entrez Gene)
PIP5K1CGeneProduct508819 (Entrez Gene)
PLCG1GeneProduct281987 (Entrez Gene)
PLCG2GeneProduct281988 (Entrez Gene)
PLEKHA1GeneProduct513040 (Entrez Gene)
PLEKHA2GeneProduct530879 (Entrez Gene)
PPP3CAGeneProduct286852 (Entrez Gene)
PPP3CBGeneProduct790867 (Entrez Gene)
PPP3R1GeneProduct282321 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCEGeneProduct507041 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKD1GeneProduct533270 (Entrez Gene)
PTK2GeneProduct506270 (Entrez Gene)
PTK2BGeneProduct541008 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN18GeneProduct617215 (Entrez Gene)
PTPN6GeneProduct512312 (Entrez Gene)
PTPRCGeneProduct407152 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAP2AGeneProduct522707 (Entrez Gene)
RAPGEF1GeneProduct520454 (Entrez Gene)
RASA1GeneProduct282032 (Entrez Gene)
RASGRP3GeneProduct523745 (Entrez Gene)
RB1GeneProduct534712 (Entrez Gene)
RELGeneProduct509135 (Entrez Gene)
RELAGeneProduct508233 (Entrez Gene)
RHOAGeneProduct338049 (Entrez Gene)
RPS6GeneProduct782738 (Entrez Gene)
RPS6KA1GeneProduct533908 (Entrez Gene)
RPS6KB1GeneProduct404181 (Entrez Gene)
SH2B2GeneProduct617840 (Entrez Gene)
SH3BP2GeneProduct
SHC1GeneProduct507196 (Entrez Gene)
SLA2GeneProduct514398 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
STAP1GeneProduct507296 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
SYKGeneProduct515515 (Entrez Gene)
TECGeneProduct504733 (Entrez Gene)
VAV1GeneProduct617345 (Entrez Gene)
VAV2GeneProduct
WASGeneProduct
ZAP70GeneProduct504509 (Entrez Gene)
cd21GeneProduct407126 (Entrez Gene)

Annotated Interactions

No annotated interactions
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