DNA replication (Bos taurus)

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1-3Mcm10Mcm4Orc complexMcm5Orc5Cdt1Orc complexMcm4Mcm6Degraded by proteasome in cytosolOrc2Phosphorylated Orc1DNA polymerase alpha:primase: origin complexOrc5Cdc6Orc5p70Cdc6DNA polymerase alpha:primase: origin complex2. Activation of the pre-replicative complexRFC36RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerOrc4Orc3Mcm10RFC40Cdc6Cdc6RNA PrimerOrc complex4. Switching of origins to post-replicative stateMcm7RNA primer-DNA primer:origin duplex:PCNAOrc complexp180Mcm2Mcm6Ubiquitinated Orc1Cdt1Degraded byproteasomein cytosolOrc3GemininUbiquitinated Cdc6RFC383. DNA replication initiationRNA primer-DNA primerMcm 4,6,7 trimer forms andassociates with the replication fork1. Assembly of the pre-replicative complexp49Orc2Mcm5RFC140Mcm2Mcm3Orc2Phosphorylation ofMcm 2-7 complexOrc4UbiquitinOrc2Orc complexPhosphorylated Cdc6Cdt1Pre-replicative complexp58Mcm3Orc15. Leading/lagging strand synthesisRNA primer-DNA primerCdt1Orc3PrimaseMcm7RFC Heteropentamer:RNA primer-DNA primerOriginPre-replicative complexRFC37Processive complexDNAPolymerase ACdt1UbiquitinOrc3GMNNPOLA2ORC1LRFC3UBCPRIM2RFC1ADPATPRFC4POLD4RPA3RPA4RFC2UTPADPRPA1POLECTPATPGTPCDT1UBA52POLE2MCM10MCM7PRIM1RFC5POLD1MCM3ORC4LDBF4ORC2LMCM6dUTPATPCDC45LCDC6POLD3ORC5LdCTPdGTPMCM2dATPORC3LPCNACDC7MCM4MCM5ORC6LPOLD2POLA1ATPCDK2RPA2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 69% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
129334view09:08, 27 March 2024MkutmonOntology Term : 'DNA replication pathway' added !
128701view17:08, 20 February 2024Khanspersremoved brackets and connected interactions
117497view11:03, 21 May 2021EweitzModified title
107078view14:16, 17 September 2019MaintBotChEBI identifier normalization
96303view18:26, 7 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
89896view13:12, 6 October 2016MkutmonModified description
89894view13:10, 6 October 2016MkutmonModified description
89892view13:08, 6 October 2016MkutmonReverted to version '15:28, 30 June 2015' by Mkutmon
89890view13:08, 6 October 2016MkutmonModified description
80850view15:28, 30 June 2015Mkutmonhomology conversion
71396view19:00, 17 October 2013MaintBotAutomated update of data sources
67167view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
63318view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
40499view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35220view15:52, 11 February 2010Thomasadded literature
35208view15:43, 11 February 2010ThomasModified description
35206view15:42, 11 February 2010ThomasModified description
33743view23:56, 8 December 2009MaintBotAutomatic update of empty xrefs
33627view10:04, 1 December 2009MaintBotRemoved group label
31638view22:25, 13 August 2009MaintBotFixed text labels
30552view22:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CDC45LGeneProduct507122 (Entrez Gene)
CDC6GeneProduct515301 (Entrez Gene)
CDC7GeneProduct516094 (Entrez Gene)
CDK2GeneProduct519217 (Entrez Gene)
CDT1GeneProduct519016 (Entrez Gene)
CTPMetabolite
DBF4GeneProduct510916 (Entrez Gene)
GMNNGeneProduct526377 (Entrez Gene)
GTPMetabolite
MCM10GeneProduct527595 (Entrez Gene)
MCM2GeneProduct510120 (Entrez Gene)
MCM3GeneProduct281302 (Entrez Gene)
MCM4GeneProduct504367 (Entrez Gene)
MCM5GeneProduct506970 (Entrez Gene)
MCM6GeneProduct517812 (Entrez Gene)
MCM7GeneProduct539924 (Entrez Gene)
ORC1LGeneProduct513523 (Entrez Gene)
ORC2LGeneProduct511281 (Entrez Gene)
ORC3LGeneProduct523714 (Entrez Gene)
ORC4LGeneProduct529245 (Entrez Gene)
ORC5LGeneProduct519409 (Entrez Gene)
ORC6LGeneProduct515476 (Entrez Gene)
PCNAGeneProduct515499 (Entrez Gene)
POLA1GeneProduct534848 (Entrez Gene)
POLA2GeneProduct514793 (Entrez Gene)
POLD1GeneProduct281990 (Entrez Gene)
POLD2GeneProduct281991 (Entrez Gene)
POLD3GeneProduct537616 (Entrez Gene)
POLD4GeneProduct617899 (Entrez Gene)
POLEGeneProduct
POLE2GeneProduct518653 (Entrez Gene)
PRIM1GeneProduct506240 (Entrez Gene)
PRIM2GeneProduct514682 (Entrez Gene)
RFC1GeneProduct
RFC2GeneProduct508652 (Entrez Gene)
RFC3GeneProduct515602 (Entrez Gene)
RFC4GeneProduct504637 (Entrez Gene)
RFC5GeneProduct508389 (Entrez Gene)
RPA1GeneProduct504844 (Entrez Gene)
RPA2GeneProduct507912 (Entrez Gene)
RPA3GeneProduct512754 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct615199 (Entrez Gene)
UBCGeneProduct444874 (Entrez Gene)
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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