Hedgehog signaling pathway (Danio rerio)

From WikiPathways

Jump to: navigation, search
1, 2Reaction through unknown mechanisms/moleculesControlPMGlycosylationAutophosphorylationEndoplasmic reticulumRecruitmentProteins in a complex interactionMolecule in the pathwayDephosphorylationCY->NUDDemethylationGolgi apparatusEnzyme complexERMethylationExtracellularTranslocationDeacetylationGONUDeubiquitinationMolecular AssociationCytoplasmEndosomeECInhibitionUbiquitinationPlasma membraneAccession Number: NetPath 10; cellmap:10PM->ENPM->ENLigandCY->PMNucleusPalmitoylationGene SymbolAcetylationDesumoylationDMitochondrionCY->NUCY->NUCY->NU(Protein-protein interaction)MTCYActivationReceptorPhosphorylationProteolytic cleavageENCY->NUSumoylationDSHHptc1gli3dyrk1aaDHHsufuccnb1SAP18STK36crebbpbptc1PTCHPTCHIHHgli2askiaIGF2hhipsufugli3gli1ccnb1DHHgli2ahhipGAS1sufuDHHPTCHPTCHcdc2rab23SIN3ASHHIHHSHHSHHgli1smoptc1hhipIHHcdc2rab23smo


Description

The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Comments

GenMAPP notes 
NetPath:10 ; cellmap:10 - Hedgehog Signaling Pathway

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP47(r20775) with a 57% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Mohler J; ''Requirements for hedgehod, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.''; Genetics, 1988 PubMed Europe PMC Scholia
  2. Lum L, Beachy PA; ''The Hedgehog response network: sensors, switches, and routers.''; Science, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117986view11:23, 23 May 2021EweitzModified title
68651view05:05, 6 July 2013MaintBotUpdated to 2013 gpml schema
67328view10:38, 26 June 2013Christine ChichesterOntology Term : 'Hedgehog signaling pathway' added !
40819view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
35746view23:54, 12 February 2010AlexanderPico
34207view21:30, 9 December 2009MaintBotAutomatic update of empty xrefs
31367view20:36, 13 August 2009MaintBotFixed text labels
31064view01:27, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DHHGeneProduct558147 (Entrez Gene)
GAS1GeneProduct
IGF2GeneProduct
IHHGeneProduct
PTCHGeneProduct
SAP18GeneProduct393693 (Entrez Gene)
SHHGeneProduct
SIN3AGeneProduct
STK36GeneProduct
ccnb1GeneProduct58025 (Entrez Gene)
cdc2GeneProduct80973 (Entrez Gene)
crebbpbGeneProduct503776 (Entrez Gene)
dyrk1aaGeneProduct100005019 (Entrez Gene)
gli1GeneProduct352930 (Entrez Gene)
gli2aGeneProduct30154 (Entrez Gene)
gli3GeneProduct403042 (Entrez Gene)
hhipGeneProduct326102 (Entrez Gene)
ptc1GeneProduct30181 (Entrez Gene)
rab23GeneProduct553778 (Entrez Gene)
skiaGeneProduct30101 (Entrez Gene)
smoGeneProduct30225 (Entrez Gene)
sufuGeneProduct100001615 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools