Transcriptional activation by NRF2 in response to phytochemicals (Homo sapiens)
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Description
Based on Surh, 2003, figure 4.
Nrf2 induces the expression of many antioxidant enzymes. It is therefore thought to be involved in oxidative stress response.
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Ontology Terms
Bibliography
- Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
- Niture SK, Khatri R, Jaiswal AK; ''Regulation of Nrf2-an update.''; Free Radic Biol Med, 2014 PubMed Europe PMC Scholia
- Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
6-HITC | Metabolite | Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi | |
C/EBP-beta | GeneProduct | 1051 (Entrez Gene) | |
Caffeic acid phenethyl ester | Metabolite | ||
Curcumin | Metabolite | HMDB02269 (HMDB) | |
ERK | GeneProduct | 2048 (Entrez Gene) | |
GCLC | GeneProduct | 2729 (Entrez Gene) | |
GCLM | GeneProduct | 2730 (Entrez Gene) | |
GSTA2 | GeneProduct | GSTA2 (HGNC) | |
HO-1 | GeneProduct | 3162 (Entrez Gene) | |
JNK | GeneProduct | 5599 (Entrez Gene) | |
KEAP1 | GeneProduct | 9817 (Entrez Gene) | |
MAF | GeneProduct | 4094 (Entrez Gene) | |
NQO1 | GeneProduct | 1728 (Entrez Gene) | |
NRF2 | GeneProduct | 4780 (Entrez Gene) | |
P38 | GeneProduct | 7965 (Entrez Gene) | |
PI3K | GeneProduct | 5290 (Entrez Gene) | |
PKC | GeneProduct | 5578 (Entrez Gene) | |
Sulforaphane | Metabolite | HMDB05792 (HMDB) |
Annotated Interactions
No annotated interactions