Lysine biosynthesis (Saccharomyces cerevisiae)

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1H2OCO22-oxoglutarateL-2-aminoadipateNADPsaccharopineH2Oaminoadipate-6-semialdehyde2-oxoglutarateNADPH2OH2OH2OH2Ohomoaconitatehomo-isocitratealpha-ketoadipateNADNADhomocitrate2-oxoglutarateLYS1LYS21NADHNADPHLYS2LYS9NADPHL-lysineLYS12NADHLYS20acetyl-CoAL-glutamateLYS4LYS4Coenzyme AL-glutamate


Description

S. cerevisiae synthesizes the essential amino acid L-lysine via the L-alpha-aminoadipic acid pathway instead of the diaminopmelate pathway (CITS: [10714900]). Originally proposed to be characteristic of fungi, recent studies suggest prokaryotes also synthesize lysine via the alpha-aminoadipic acid pathway (CITS: [11029074]). Intermediates in this pathway are often incorporated into secondary metabolites. For example, it has been well- studied that alpha-aminoadipate is required for penicillin production (CITS: [10714900]). Regulation of the lysine biosynthetic pathway in S. cerevisiae is an interaction between general amino acid control (via Gcn4p) (CITS: [Hinnebusch]), feedback inhibition of homocitrate synthase activity by lysine (CITS: [10103047]), and induction of Lys14p by alpha-aminoadipate semialdehyde (CITS: [10975256]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

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Ontology Terms

 

Bibliography

  1. ''L-lysine biosynthesis IV''; https://biocyc.org/pathway?orgid=META&id=LYSINE-AMINOAD-PWY,
  2. Zabriskie TM, Jackson MD; ''Lysine biosynthesis and metabolism in fungi.''; Nat Prod Rep, 2000 PubMed Europe PMC Scholia
  3. Nishida H, Nishiyama M; ''What is characteristic of fungal lysine synthesis through the alpha-aminoadipate pathway?''; J Mol Evol, 2000 PubMed Europe PMC Scholia
  4. Feller A, Ramos F, Piérard A, Dubois E; ''In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p.''; Eur J Biochem, 1999 PubMed Europe PMC Scholia
  5. El Alami M, Feller A, Piérard A, Dubois E; ''Characterisation of a tripartite nuclear localisation sequence in the regulatory protein Lys14 of Saccharomyces cerevisiae.''; Curr Genet, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135187view13:37, 7 August 2024EgonwAdded references from the description to the formal reference list
135186view13:33, 7 August 2024EgonwAnother URL citation
130617view04:42, 29 May 2024KhanspersOntology Term : 'classic metabolic pathway' added !
130616view04:41, 29 May 2024Khanspersoverhaul: updated interactions, xrefs, enzymes, layout
117310view11:18, 20 May 2021EweitzModified title
89692view10:11, 26 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69940view20:14, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69660view20:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67437view11:01, 26 June 2013DdiglesOntology Term : 'lysine biosynthetic pathway' added !
41900view04:53, 2 March 2011MaintBotRemoved redundant pathway information and comments
36626view22:33, 9 April 2010MaintBotDescription and bibliography added from SGD
21800view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Lysine Biosynthesis]] moved to [[Pathway:WP533]]: Moved to stable identifier
12774view08:02, 17 May 2008MaintBotautomated metabolite conversion
8822view14:09, 7 January 2008MaintBotAdded to category $category
8820view14:09, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Coenzyme A64885-97-8 (CAS)
L-glutamate56-86-0 (CAS)
L-lysine56-87-1 (CAS)
LYS12GeneProductS000001356 (SGD)
LYS1GeneProductS000001473 (SGD)
LYS20GeneProductS000002341 (SGD)
LYS21GeneProductS000002289 (SGD)
LYS2GeneProductS000000319 (SGD)
LYS4GeneProductS000002642 (SGD)
LYS9GeneProductS000005333 (SGD)
NADH53-84-9 (CAS)
NADPH2646-71-1 (CAS)
acetyl-CoA72-89-9 (CAS)

Annotated Interactions

No annotated interactions
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