Glucocorticoid effect on target gene expression (Rattus norvegicus)
From WikiPathways
Description
This pathway provides a clear view of the effects of Glucocorticoids on target gene expression when binding to the GR (glucocorticoid receptor). Inhibiting and activiting effects are given as a result of target gene activation.
It summarizes the article of Pelaia et al, 2002, which explains the pathway very detailed.
Quality Tags
Ontology Terms
Bibliography
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- Smith DF, Toft DO; ''Steroid receptors and their associated proteins.''; Mol Endocrinol, 1993 PubMed Europe PMC Scholia
- Glass CK, Rosenfeld MG; ''The coregulator exchange in transcriptional functions of nuclear receptors.''; Genes Dev, 2000 PubMed Europe PMC Scholia
- Riccardi C, Cifone MG, Migliorati G; ''Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes.''; Cell Death Differ, 1999 PubMed Europe PMC Scholia
- Flower RJ, Rothwell NJ; ''Lipocortin-1: cellular mechanisms and clinical relevance.''; Trends Pharmacol Sci, 1994 PubMed Europe PMC Scholia
- Ito K, Barnes PJ, Adcock IM; ''Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
- Adcock IM, Ito K; ''Molecular mechanisms of corticosteroid actions.''; Monaldi Arch Chest Dis, 2000 PubMed Europe PMC Scholia
- Dong C, Davis RJ, Flavell RA; ''MAP kinases in the immune response.''; Annu Rev Immunol, 2002 PubMed Europe PMC Scholia
- Barnes PJ, Adcock IM; ''NF-kappa B: a pivotal role in asthma and a new target for therapy.''; Trends Pharmacol Sci, 1997 PubMed Europe PMC Scholia
- Bertorelli G, Bocchino V, Olivieri D; ''Heat shock protein interactions with the glucocorticoid receptor.''; Pulm Pharmacol Ther, 1998 PubMed Europe PMC Scholia
- Pelaia G, Vatrella A, Cuda G, Maselli R, Marsico SA; ''Molecular mechanisms of corticosteroid actions in chronic inflammatory airway diseases.''; Life Sci, 2003 PubMed Europe PMC Scholia
- Barnes PJ; ''Therapeutic strategies for allergic diseases.''; Nature, 1999 PubMed Europe PMC Scholia
- Ayer DE; ''Histone deacetylases: transcriptional repression with SINers and NuRDs.''; Trends Cell Biol, 1999 PubMed Europe PMC Scholia
- Barnes PJ, Pedersen S, Busse WW; ''Efficacy and safety of inhaled corticosteroids. New developments.''; Am J Respir Crit Care Med, 1998 PubMed Europe PMC Scholia
- Mitchell PJ, Tjian R; ''Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.''; Science, 1989 PubMed Europe PMC Scholia
- Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB; ''Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.''; Nature, 1991 PubMed Europe PMC Scholia
- Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C; ''Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB.''; Blood, 2001 PubMed Europe PMC Scholia
- Barnes PJ; ''Cytokine modulators as novel therapies for asthma.''; Annu Rev Pharmacol Toxicol, 2002 PubMed Europe PMC Scholia
- Bickel M, Cohen RB, Pluznik DH; ''Post-transcriptional regulation of granulocyte-macrophage colony-stimulating factor synthesis in murine T cells.''; J Immunol, 1990 PubMed Europe PMC Scholia
- Nightingale KP, Wellinger RE, Sogo JM, Becker PB; ''Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin.''; EMBO J, 1998 PubMed Europe PMC Scholia
- McKay LI, Cidlowski JA; ''Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways.''; Endocr Rev, 1999 PubMed Europe PMC Scholia
- Pelaia G, Marsico SA; ''Regulation of beta 2-adrenergic receptors and the implications for bronchial asthma: an update.''; Monaldi Arch Chest Dis, 1994 PubMed Europe PMC Scholia
- Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, Mueller M, Gaestel M, Resch K, Holtmann H; ''The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.''; EMBO J, 1999 PubMed Europe PMC Scholia
- Newton R, Seybold J, Kuitert LM, Bergmann M, Barnes PJ; ''Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
- Barnes PJ; ''Beta-adrenergic receptors and their regulation.''; Am J Respir Crit Care Med, 1995 PubMed Europe PMC Scholia
- Umland SP, Schleimer RP, Johnston SL; ''Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma.''; Pulm Pharmacol Ther, 2002 PubMed Europe PMC Scholia
- Pelaia G, Vatrella A, Calabrese C, Mazzarella G, Marsico SA; ''New perspectives in asthma treatment.''; Allergy, 2000 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Anti-Inflammatory Proteins | GeneProduct | ||
COX-2 | GeneProduct | ENSRNOG00000030371 (Ensembl) | |
DNA unwinding | Pathway | ||
GILZ | GeneProduct | ENSRNOG00000013786 (Ensembl) | |
GITR | GeneProduct | 500598 (Entrez Gene) | |
Glucocorticoid Receptor | GeneProduct | 24413 (Entrez Gene) | |
Glucocorticoids | Metabolite | ||
Hsp70 | GeneProduct | ENSRNOG00000016596 (Ensembl) | |
Hsp90aa1 | GeneProduct | ENSRNOG00000007219 (Ensembl) | |
Hsp90ab1 | GeneProduct | ENSRNOG00000019834 (Ensembl) | |
IkB-alpha | GeneProduct | ENSRNOG00000007390 (Ensembl) | |
MAP kinase pathway | Pathway | ||
Nf-kB, etc | GeneProduct | ENSRNOG00000023258 (Ensembl) | |
Nf-kB | GeneProduct | ENSRNOG00000023258 (Ensembl) | |
Rras | GeneProduct | ENSRNOG00000037247 (Ensembl) | |
adhesion molecules | GeneProduct | ||
beta2 adrenergic receptor | GeneProduct | ENSRNOG00000019217 (Ensembl) | |
chemokines | GeneProduct | ||
cytokines | GeneProduct | ||
lipid mediators | GeneProduct | ||
lipocortin-1 | GeneProduct | ENSRNOG00000017469 (Ensembl) | |
mediator-synthesizing enzymes | GeneProduct | ||
p59 | GeneProduct | 260321 (Entrez Gene) | |
phospholipase A2 | GeneProduct | ENSRNOG00000002657 (Ensembl) |
Annotated Interactions
No annotated interactions