Type II interferon signaling (IFNG) (Rattus norvegicus)

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Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

HomologyConvert 

This pathway was inferred from Homo sapiens pathway WP619(r28124) with a 94% conversion rate.