Complement activation, classical pathway (Canis familiaris)
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Proteolytic Cleavage
Cytoplasm
aggregated IgG,
IgM-antigen complex,
polyanions, RNA, DNA
lipopolysaccharides
Prevents Complement Attack
antigen/antibody
complex
Complex
Formation
Ions
C1 complex
Membrane
attack complex
Plasma
Membrane
C4A
C1R
C4B
C1S
MASP1
C6
C9
C8A
C5
C1QC
C3
C1QA
C2
C8B
H2O
C1QB
C7
CD55
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP545(r21826)
with a 76% conversion rate.
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Bibliography
No bibliography
History
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Compare
Revision
Action
Time
User
Comment
118078
view
10:43, 24 May 2021
Eweitz
Modified title
106032
view
11:55, 16 August 2019
MaintBot
HMDB identifier normalization
89188
view
03:55, 23 August 2016
Ariutta
Ontology Term : 'regulatory pathway' added !
89187
view
03:55, 23 August 2016
Ariutta
Ontology Term : 'classical complement pathway' added !
68543
view
22:29, 5 July 2013
MaintBot
Updated to 2013 gpml schema
40699
view
21:51, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33981
view
18:32, 9 December 2009
MaintBot
Automatic update of empty xrefs
32543
view
13:03, 17 August 2009
MaintBot
Fixed text labels
32226
view
12:48, 15 August 2009
MaintBot
Fixed text labels
31724
view
11:56, 14 August 2009
MaintBot
Fixed group labels
31241
view
19:48, 13 August 2009
MaintBot
Fixed text labels
30664
view
22:37, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
C1QA
GeneProduct
478194 (Entrez Gene)
update: C1QA HUMAN
C1QB
GeneProduct
487381 (Entrez Gene)
C1QC
GeneProduct
487382 (Entrez Gene)
update C1QC HUMAN
C1R
GeneProduct
477707 (Entrez Gene)
C1S
GeneProduct
486714 (Entrez Gene)
C2
GeneProduct
C3
GeneProduct
476728 (Entrez Gene)
C4A
GeneProduct
C4B
GeneProduct
C5
GeneProduct
474816 (Entrez Gene)
C6
GeneProduct
479348 (Entrez Gene)
C7
GeneProduct
489221 (Entrez Gene)
C8A
GeneProduct
479556 (Entrez Gene)
C8B
GeneProduct
479555 (Entrez Gene)
C9
GeneProduct
479354 (Entrez Gene)
CD55
GeneProduct
609307 (Entrez Gene)
H2O
Metabolite
HMDB02111 (HMDB)
MASP1
GeneProduct
488121 (Entrez Gene)
Annotated Interactions
No annotated interactions
Views
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Discussion
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View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
No annotated interactions