TNF-alpha NF-kB signaling pathway (Canis familiaris)

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Proteins in a complex interactionCY ->NU(Protein-protein interaction)LigandMethylationCY ->NUExtracellularPhosphorylationDeubiquitinationAutophosphorylationPlasma membraneEndosomeCY ->NUProteolytic cleavageCYENEnzyme complexDemethylationDGolgi apparatusMitochondrionCY ->NUAcetylationPalmitoylationMolecule in the pathwayERGlycosylationECDesumoylationDeacetylationMTGOTranslocationNUActivationControlMolecular associationReaction through unknown mechanisms/moleculesCY ->NUSumoylationInhibitionUbiquitinationDephosphorylationPMEndoplasmic reticulumRecruitmentNucleusCytoplasmAccession Number: NetPath 9; cellmap:9ReceptorIQGAP2NFKBIANR2C2CSNK2A2RPS11RPS6KA5GTF2INFKB2PSMC3RNF216RIPK1MAP3K7IP3CHUKBIRC3NFKB1RELAYWHAGTBK1TRAF6TRAF2BAG4RIPK3RELARPS6KB1FADDLOC480907MAP2K5RELTRAF2TRAF1YWHABTXLNATNFSMARCB1DPF2CAPN3CREBBPCDC34CASP2AKT2CSNK2A1PFDN2SMARCE1USP11TNFTNFMAP3K7IP2Gene SymbolSMARCC2TNFAIP3NFKBIBRNF25MAP3K7IP1TNFYWHAQRIPK1GLG1LOC480438TNFRSF1ARELBKPNA6RPL6DAPSRCYWHAZTNFRSF8POLR1AKTN1AZI2IKBKAPTNFRSF1BCFLARLOC487309PEG3IKBKELOC612286BIRC3NR2C2CRADDNSMAFMAP3K3BCL3CASP7TRAF4PAPOLAAKT1PRKCZCASP10G3BP2UBCH5CHIST3H3CYLDCAV1TRADDFBXW11NFKBIERPL8PKN1POLR1CBTRCPSMD6LOC475035NFKBIASMARCA4PTPN11CHUKPIAS3RASAL2POLR2LALPLMCCNFKB1TRAF5TNFCOPS3GeneTIFAFLNAMAP3K1GeneBCL7AFBLGNB2L1MAP3K14RELUBE2ITNFRSF1BYWHAEPRKACATRAF3GAB1PMLTNFRSF1ATRAF4PPP2CATANKTBK1PSMD3AKAP8MCM7FAF1EIF4A3COMMD1RELARPL30SKP1TNFRSF11AGSK3BTRAF1CASP3CDC37SUMO1PSMD13NKIRAS2MAP3K3IKBKGTRAF2TRAIPHSPB1ZFAND5PSMD12RELBACTL6AHSP90AB1CASP8TNIP2RPL4MAP3K8IKBKGRIPK2WDR68POLR2HCD3EAPPSMC1PSMB5PSMD1TNFRSF1AKPNA3MCM5LOC486122DDX3XMTIF2FANCD2PDCD2TRPC4APSTAT1TNFYWHAHCUL1NFKB1MAP3K2KCNQ1POLR1DTRADDPOLR1BPSMD7PSMC2PTK2IKBKBRELANALP4GeneLRPPRCUSP2UNC5CLUBE2D2GeneRPS13NKIRAS1POLR1EMARK2TNFRSF1BCASP8AP2FKBP5BIRC2TNIP1CSNK2BKPNA2NFKBIZNFKBIASMARCC1PEBP1BIRC2


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 87% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118009view11:31, 23 May 2021EweitzModified title
108149view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87779view11:09, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87778view11:08, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68568view22:53, 5 July 2013MaintBotUpdated to 2013 gpml schema
40726view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
34005view18:39, 9 December 2009MaintBotAutomatic update of empty xrefs
32256view12:58, 15 August 2009MaintBotFixed text labels
31777view12:10, 14 August 2009MaintBotFixed group labels
31281view20:02, 13 August 2009MaintBotFixed text labels
30732view23:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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ZFAND5GeneProduct476324 (Entrez Gene)

Annotated Interactions

No annotated interactions
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