Complement activation, classical pathway (Gallus gallus)
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Cytoplasm
aggregated IgG,
IgM-antigen complex,
polyanions, RNA, DNA
lipopolysaccharides
Complex
Formation
Ions
Plasma
Membrane
Proteolytic Cleavage
C1 complex
Prevents Complement Attack
antigen/antibody
complex
Membrane
attack complex
C8A
C1QA
C8B
C1QB
C1R
C4B
C2
C7
C5
H2O
MASP1
C4A
DAF
C1S
C6
C9
C3
C1QC
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP545(r21826)
with a 76% conversion rate.
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Bibliography
No bibliography
History
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Compare
Revision
Action
Time
User
Comment
118080
view
10:43, 24 May 2021
Eweitz
Modified title
106107
view
12:01, 16 August 2019
MaintBot
HMDB identifier normalization
89190
view
03:55, 23 August 2016
Ariutta
Ontology Term : 'regulatory pathway' added !
89189
view
03:55, 23 August 2016
Ariutta
Ontology Term : 'classical complement pathway' added !
68815
view
17:16, 8 July 2013
MaintBot
Updated to 2013 gpml schema
40950
view
22:53, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33438
view
14:57, 30 November 2009
MaintBot
Removed group label
31495
view
21:31, 13 August 2009
MaintBot
Fixed text labels
30320
view
20:43, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
C1QA
GeneProduct
419504 (Entrez Gene)
update: C1QA HUMAN
C1QB
GeneProduct
428197 (Entrez Gene)
C1QC
GeneProduct
419503 (Entrez Gene)
update C1QC HUMAN
C1R
GeneProduct
418295 (Entrez Gene)
C1S
GeneProduct
418294 (Entrez Gene)
C2
GeneProduct
419574 (Entrez Gene)
C3
GeneProduct
396370 (Entrez Gene)
C4A
GeneProduct
C4B
GeneProduct
C5
GeneProduct
417122 (Entrez Gene)
C6
GeneProduct
431585 (Entrez Gene)
C7
GeneProduct
427187 (Entrez Gene)
C8A
GeneProduct
429111 (Entrez Gene)
C8B
GeneProduct
424669 (Entrez Gene)
C9
GeneProduct
DAF
GeneProduct
H2O
Metabolite
HMDB02111 (HMDB)
MASP1
GeneProduct
407088 (Entrez Gene)
Annotated Interactions
No annotated interactions
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