Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)

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1, 11, 144, 73, 6, 8, 10, 12...4, 7225, 94, 74, 724, 7mitochondrial intermembrane spacemitochondrial matrixATPubiquinolFatty Acid anion "head-in"Purine nucleotideATPase complexFA anion:UCP dimer "head-in" complexFA anion:UCP dimer "head-out" complexOxygenubiquinoneubiquinoneLong-chain fatty acidubiquinolADPATPase-ATP complexH2OUCP dimerSuccinate dehydrogenase complex (reduced)Complex I - NADH:Ubiquinone oxidoreductaseETF (reduced)Fatty Acid "head-out"Cytochrome c (reduced)Cytochrome c (oxidized)UCP dimerH+Ubiquinol-cytochrome c reductaseFatty Acid "head-in"Cytochrome c oxidaseSuccinate dehydrogenase complex (oxidised)NAD+ubiquinolFADH2Fatty Acid anion "head-out"FADETFDHETFOrthophosphateH+H2ONADHATPase-ADP and Pi complex


Description

Oxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of protons from the mitochonrial matrix, generating a chemiosmotic gradient across the inner mitochondrial membrane. This gradient is used to drive the synthesis of ATP; it can also be bypassed by uncoupling proteins to generate heat, a reaction in brown fat that may be important in regulation of body temperature in newborn children.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114966view16:49, 25 January 2021ReactomeTeamReactome version 75
113410view11:48, 2 November 2020ReactomeTeamReactome version 74
112612view15:59, 9 October 2020ReactomeTeamReactome version 73
101528view11:39, 1 November 2018ReactomeTeamreactome version 66
101063view21:21, 31 October 2018ReactomeTeamreactome version 65
100594view19:55, 31 October 2018ReactomeTeamreactome version 64
100143view16:40, 31 October 2018ReactomeTeamreactome version 63
99693view15:09, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99281view12:45, 31 October 2018ReactomeTeamreactome version 62
93907view13:44, 16 August 2017ReactomeTeamreactome version 61
93481view11:24, 9 August 2017ReactomeTeamreactome version 61
86578view09:21, 11 July 2016ReactomeTeamreactome version 56
83426view11:11, 18 November 2015ReactomeTeamVersion54
81630view13:10, 21 August 2015ReactomeTeamVersion53
77091view08:38, 17 July 2014ReactomeTeamFixed remaining interactions
76797view12:18, 16 July 2014ReactomeTeamFixed remaining interactions
76120view10:18, 11 June 2014ReactomeTeamRe-fixing comment source
75832view11:40, 10 June 2014ReactomeTeamReactome 48 Update
75192view09:40, 9 May 2014AnweshaFixing comment source for displaying WikiPathways description
74837view10:06, 30 April 2014ReactomeTeamReactome46
74431view07:10, 19 April 2014EgonwRelocated an InfoBox.
68937view17:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
45047view19:09, 6 October 2011ThomasOntology Term : 'energy metabolic pathway' added !
42118view21:58, 4 March 2011MaintBotAutomatic update
39928view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
ATPase

complex

ComplexREACT_4862 (Reactome)
ATPase-ADP and

Pi complex

ComplexREACT_2435 (Reactome)
ATPase-ATP

complex

ComplexREACT_3945 (Reactome)
Complex I -

NADH: Ubiquinone oxidoreductase

ComplexREACT_6533 (Reactome)
Cytochrome

c oxidase

ComplexREACT_6661 (Reactome)
Cytochrome c

(oxidized)

ComplexREACT_13953 (Reactome)
Cytochrome c

(reduced)

ComplexREACT_13858 (Reactome)
ETF ComplexREACT_6490 (Reactome)
ETF

(reduced)

ComplexREACT_6568 (Reactome)
ETFDH ProteinQ16134 (UniProt)
FA anion:UCP

dimer "head- out" complex

ComplexREACT_6437 (Reactome)
FA anion:UCP

dimer "head-in" complex

ComplexREACT_6679 (Reactome)
FAD Metabolite16238 (ChEBI)
FADH2 Metabolite17877 (ChEBI)
Fatty Acid

"head-in"

REACT_6592 (Reactome)
Fatty Acid

"head-out"

REACT_6554 (Reactome)
Fatty Acid

anion "head-out"

REACT_6652 (Reactome)
Fatty Acid anion

"head-in"

REACT_6375 (Reactome)
H+ Metabolite15378 (ChEBI)
H2O Metabolite15377 (ChEBI)
Long-chain

fatty acid

15904 (ChEBI)
NAD+ Metabolite15846 (ChEBI)
NADH Metabolite16908 (ChEBI)
Orthophosp

hate

Metabolite18367 (ChEBI)
Oxygen Metabolite15379 (ChEBI)
Purine

nucleotide

REACT_6384 (Reactome)
Succinate

dehydrogenase complex (oxidised)

ComplexREACT_3127 (Reactome)
Succinate

dehydrogenase complex (reduced)

ComplexREACT_6402 (Reactome)
UCP

dimer

ComplexREACT_6463 (Reactome)
Ubiquinol-

cytochrome c reductase

ComplexREACT_6527 (Reactome)
ubiquinol Metabolite17976 (ChEBI)
ubiquinone Metabolite16389 (ChEBI)

Annotated Interactions

No annotated interactions

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