Trans-sulfuration pathway (Homo sapiens)
From WikiPathways
Description
Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.
Quality Tags
Ontology Terms
Bibliography
- Beger RD, Sun J, Schnackenberg LK.; ''Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity''; doi: 10.1016/j.taap.2009.11.019, 2010 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
5-Methyl-THF | Metabolite | C00440 (Kegg Compound) | |
ADP | Metabolite | C00008 (Kegg Compound) | |
AHCY | GeneProduct | 191 (Entrez Gene) | |
ATP | Metabolite | C00002 (Kegg Compound) | |
CBS | GeneProduct | 875 (Entrez Gene) | |
CSAD | GeneProduct | 51380 (Entrez Gene) | |
CTH | GeneProduct | 1491 (Entrez Gene) | |
DNA, proteins, metabolites | |||
DNMT1 | GeneProduct | 1786 (Entrez Gene) | |
GCLM | GeneProduct | 2730 (Entrez Gene) | |
GOT1 | GeneProduct | 2805 (Entrez Gene) | |
Glutathione | Metabolite | C00051 (Kegg Compound) | |
L-Cysteine | Metabolite | C00097 (Kegg Compound) | |
L-Glutamate | Metabolite | C00025 (Kegg Compound) | |
L-Homocysteine | Metabolite | C00155 (Kegg Compound) | |
L-Methionine | Metabolite | C00073 (Kegg Compound) | |
MAT2B | GeneProduct | 27430 (Entrez Gene) | |
MPST | GeneProduct | 4357 (Entrez Gene) | |
MTR | GeneProduct | 4548 (Entrez Gene) | |
Methylated products | |||
Phosphate | Metabolite | C00009 (Kegg Compound) | |
Pyruvate | Metabolite | C00022 (Kegg Compound) | |
S-Adenosylhomocysteine (SAH) | Metabolite | C00021 (Kegg Compound) | |
S-Adenosylmethionine (SAMe) | Metabolite | C00019 (Kegg Compound) | |
Taurine | Metabolite | C00245 (Kegg Compound) | |
Tetrahydrofolate (THF) | Metabolite | C00101 (Kegg Compound) |
Annotated Interactions
No annotated interactions