Presynaptic depolarization and calcium channel opening (Homo sapiens)

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1cytosolCalciumVoltage Gated Ca2+ ChannelCalcium


Description

The action potential travels down the axon and reaches the pre-synaptic terminal depolarizing the membrane in the pre-synaptic terminal. The depolarization causes the voltage-gated Ca2+ channels to open allowing the influx of Ca2+ that signals the release of neurotransmitter into the synaptic cleft.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Diriong S, Lory P, Williams ME, Ellis SB, Harpold MM, Taviaux S.; ''Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114658view16:12, 25 January 2021ReactomeTeamReactome version 75
113106view11:16, 2 November 2020ReactomeTeamReactome version 74
112340view15:26, 9 October 2020ReactomeTeamReactome version 73
101240view11:13, 1 November 2018ReactomeTeamreactome version 66
100779view20:40, 31 October 2018ReactomeTeamreactome version 65
100322view19:17, 31 October 2018ReactomeTeamreactome version 64
99867view16:00, 31 October 2018ReactomeTeamreactome version 63
99424view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99107view12:39, 31 October 2018ReactomeTeamreactome version 62
94505view09:21, 14 September 2017Mkutmonreactome version 61
86351view09:15, 11 July 2016ReactomeTeamreactome version 56
83053view09:47, 18 November 2015ReactomeTeamVersion54
81360view12:53, 21 August 2015ReactomeTeamVersion53
76829view08:05, 17 July 2014ReactomeTeamFixed remaining interactions
76533view11:50, 16 July 2014ReactomeTeamFixed remaining interactions
75866view09:51, 11 June 2014ReactomeTeamRe-fixing comment source
75566view10:36, 10 June 2014ReactomeTeamReactome 48 Update
74921view13:44, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74565view08:36, 30 April 2014ReactomeTeamReactome46
68994view17:44, 8 July 2013MaintBotUpdated to 2013 gpml schema
45188view10:00, 7 October 2011MartijnVanIerselOntology Term : 'neuron-to-neuron signaling pathways' added !
42023view21:51, 4 March 2011MaintBotAutomatic update
39826view05:51, 21 January 2011MaintBotNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
Calcium Metabolite29108 (ChEBI)
Voltage Gated Ca2+

Channel

REACT_12910 (Reactome)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1800"
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