Non-homologous end joining (Pan troglodytes)

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Q6UIL6_PANTRRAD50PRKDCXRCC4PRKDCNHEJ1Q6UIL6_PANTRQ6UIL6_PANTRNHEJ1PRKDCXRCC6XRCC6Q6UIL6_PANTRXRCC6Q6UIL6_PANTRPRKDCLigase VMRE11ANbs1 ?Q6UIL6_PANTRXRCC6XRCC6XRCC6XRCC6PRKDCQ6UIL6_PANTRXRCC6Q6UIL6_PANTRPRKDCQ6UIL6_PANTRPRKDCXRCC4XRCC6Ligase VQ6UIL6_PANTRXRCC6PRKDC


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 91% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
87951view13:06, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87950view13:06, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
69216view18:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
58897view04:46, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41518view01:56, 2 March 2011MaintBotRemoved redundant pathway information and comments
35398view09:52, 12 February 2010MartijnVanIerselModified description
33528view09:34, 1 December 2009MaintBotRemoved group label
30430view21:19, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Ligase VGeneProduct
MRE11AGeneProductENSPTRG00000004184 (Ensembl)
NHEJ1GeneProduct742646 (Entrez Gene)
NHEJ1GeneProductENSPTRG00000034481 (Ensembl)
Nbs1 ?GeneProduct
PRKDCGeneProductENSPTRG00000020229 (Ensembl)
Q6UIL6_PANTRGeneProductENSPTRG00000012896 (Ensembl)
RAD50GeneProductENSPTRG00000017218 (Ensembl)
XRCC4GeneProductENSPTRG00000017054 (Ensembl)
XRCC6GeneProductENSPTRG00000022548 (Ensembl)

Annotated Interactions

No annotated interactions
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