IL-6 Signaling Pathway (Pan troglodytes)

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AutophosphorylationEndosomeDReceptorDeacetylationDCY->EN(Protein-Protein interaction)DephosphorylationUbiquitinationDeubiquitinationDEnzyme complexInhibitionAccession Number: NetPath 18DNucleusMolecule in the pathwayComplex formationPlasma membraneDCY->NUDSumoylationPhosphorylationEarly EndosomesReactions through unknown mechanisms/moleculesDemethylationPalmitoylationCY->NUDMolecular associationPMProteins in a complex interactionEndoplasmic reticulumDGene SymbolGlycosylationDMethylationECDCY->NUDGolgi apparatusNUERDControlDActivationENMTGODTranslocationCytoplasmLigandCY->NUDesumoylationCY->NUCYExtracellularProteolytic cleavageCY->NUAcetylationRecruitmentMitochondrionSTAT3NLKLYNPPP2R3BPIK3R1CASP9PXNPPP2CBJAK2BTKFOXO4PPP2CASTAT3FESFYNGAB1EIF2ASTAT1PPP2R1AIL6RSGKSTAT5AMAPK3HNF1AEIF4ESTAT1CASP3PPP2R5BHCKSTAT3MAP2K6PTK2MAP2K2PPP2R5DSOCS3NFKB1MAPK8CDK9MAP2K1STAT1HRASSHC1CREBBPARRAC1STAT3EP300CEBPBCDK5STAT3STAT3AKT1RPS6KB1STAT3MAPK14ERBB3PTK2BPTPN11STAT3PPP2R1BFOXO3APPP2R4FOSPRKCDMAP3K7PPP2R3AGAB2PPP2R5EGSK3BCDK5R1STAT1JAK1CEBPBMAPKAPK2MAPTFGRDAXXPPP2R2BSTAT5BTYK2RAF1BMXPPP2R5CVAV1NCOA1GRB2SOS1JUNTECIL6STRPS6KA2NFKB1BADSGKPLCG1PPP2R5AIL6STIL6IL6PPP2R2CPIK3R2MAP3K7MAP2K4HSPB1INPPL1PPP2R2ACD40MAP3K4RB1FOXO1ERBB2LOC464259MAPK1IL6RMAPK14EIF4EBP1HSP90AA1INPP5D


Description

No description

Comments

GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP364(r28142) with a 79% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
86940view13:08, 15 July 2016MkutmonOntology Term : 'interleukin-6 signaling pathway' added !
69253view18:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
41560view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
34290view22:01, 9 December 2009MaintBotAutomatic update of empty xrefs
31564view21:56, 13 August 2009MaintBotFixed text labels
30427view21:18, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene)
ARGeneProduct747460 (Entrez Gene)
BADGeneProduct
BMXGeneProduct
BTKGeneProduct465759 (Entrez Gene)
CASP3GeneProduct461669 (Entrez Gene)
CASP9GeneProduct456457 (Entrez Gene)
CD40GeneProduct
CDK5GeneProduct463891 (Entrez Gene)
CDK5R1GeneProduct747897 (Entrez Gene)
CDK9GeneProduct464755 (Entrez Gene)
CEBPBGeneProduct469969 (Entrez Gene)
CREBBPGeneProduct467891 (Entrez Gene)
DAXXGeneProduct462613 (Entrez Gene)
EIF2AGeneProduct470965 (Entrez Gene)
EIF4EGeneProduct468435 (Entrez Gene)
EIF4EBP1GeneProduct464114 (Entrez Gene)
EP300GeneProduct458862 (Entrez Gene)
ERBB2GeneProduct
ERBB3GeneProduct451980 (Entrez Gene)
FESGeneProduct453654 (Entrez Gene)
FGRGeneProduct739516 (Entrez Gene)
FOSGeneProduct453047 (Entrez Gene)
FOXO1GeneProduct467352 (Entrez Gene)
FOXO3AGeneProduct
FOXO4GeneProduct473659 (Entrez Gene)
FYNGeneProduct462944 (Entrez Gene)
GAB1GeneProduct461516 (Entrez Gene)
GAB2GeneProduct748918 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
GSK3BGeneProduct470896 (Entrez Gene)
HCKGeneProduct458163 (Entrez Gene)
HNF1AGeneProduct744121 (Entrez Gene)
HRASGeneProduct466302 (Entrez Gene)
HSP90AA1GeneProduct743883 (Entrez Gene)
HSPB1GeneProduct463488 (Entrez Gene)
IL6GeneProduct463288 (Entrez Gene)
IL6RGeneProduct469506 (Entrez Gene)
IL6STGeneProduct461866 (Entrez Gene)
INPP5DGeneProduct470683 (Entrez Gene)
INPPL1GeneProduct451403 (Entrez Gene)
JAK1GeneProduct743373 (Entrez Gene)
JAK2GeneProduct464979 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
LOC464259GeneProduct464259 (Entrez Gene)
LYNGeneProduct472771 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAP2K2GeneProduct456390 (Entrez Gene)
MAP2K4GeneProduct455065 (Entrez Gene)
MAP2K6GeneProduct468310 (Entrez Gene)
MAP3K4GeneProduct
MAP3K7GeneProduct462888 (Entrez Gene)
MAPK14GeneProduct450161 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MAPKAPK2GeneProduct744091 (Entrez Gene)
MAPTGeneProduct450177 (Entrez Gene)
NCOA1GeneProduct459068 (Entrez Gene)
NFKB1GeneProduct461406 (Entrez Gene)
NLKGeneProduct739132 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PLCG1GeneProduct458253 (Entrez Gene)
PPP2CAGeneProduct471633 (Entrez Gene)
PPP2CBGeneProduct464100 (Entrez Gene)
PPP2R1AGeneProduct468983 (Entrez Gene)
PPP2R1BGeneProduct466778 (Entrez Gene)
PPP2R2AGeneProduct464068 (Entrez Gene)
PPP2R2BGeneProduct462170 (Entrez Gene)
PPP2R2CGeneProduct461101 (Entrez Gene)
PPP2R3AGeneProduct460715 (Entrez Gene)
PPP2R3BGeneProduct
PPP2R4GeneProduct464784 (Entrez Gene)
PPP2R5AGeneProduct457716 (Entrez Gene)
PPP2R5BGeneProduct
PPP2R5CGeneProduct453170 (Entrez Gene)
PPP2R5DGeneProduct462705 (Entrez Gene)
PPP2R5EGeneProduct452962 (Entrez Gene)
PRKCDGeneProduct
PTK2GeneProduct464422 (Entrez Gene)
PTK2BGeneProduct464073 (Entrez Gene)
PTPN11GeneProduct748225 (Entrez Gene)
PXNGeneProduct452303 (Entrez Gene)
RAC1GeneProduct
RAF1GeneProduct460182 (Entrez Gene)
RB1GeneProduct452715 (Entrez Gene)
RPS6KA2GeneProduct
RPS6KB1GeneProduct468426 (Entrez Gene)
SGKGeneProduct
SHC1GeneProduct457351 (Entrez Gene)
SOCS3GeneProduct454921 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
STAT3GeneProduct454682 (Entrez Gene)
STAT5AGeneProduct454681 (Entrez Gene)
STAT5BGeneProduct454679 (Entrez Gene)
TECGeneProduct461343 (Entrez Gene)
TYK2GeneProduct455703 (Entrez Gene)
VAV1GeneProduct455647 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP858"
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