Estrogen metabolism (Pan troglodytes)

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1, 2, 478773736733337736733775333676837433788DNA adductsDNA adductsDNA adductsDNA adducts4-hydroxy-estradiol-sulfateSuperoxide4-hydroxyestrone-3-glucuronide4-Methoxyestradiol2-hydroxyestradiol-3-glucuronideCOMTUGT2B7UGT1A1Oxygen2-MethoxyestradiolEstradiol-3,4-semiquinoneQ9TU62_PANTRQ9TU62_PANTREstrone-3-glucuronideQ9TU62_PANTRQ9TU62_PANTRSuperoxide4-MethoxyestroneUGT1A1UGT1A1NQO14-hydroxyestradiol4-Methoxyestradiol-3-glucuronideCYP1B14-Hydroxyestradiol-3-glucuronideEstrone-2,3-semiquinoneUGT2B7Q9TU62_PANTREstradiol-2,3-quinone2-hydroxy-estradiol-sulfateEstradiol-17-glucuronideEstroneGSTA1OxygenUGT1A9SULT1A1STS4-Methoxyestrone-3-glucuronideEstrone sulfateCOMTCYP1A1UGT2B7Q9N256_PANTRB1NL93_PANTR2-MethoxyestroneOxygen2-HydroxyestroneCOMTUGT1A9Estrone-3,4-semiquinone2-Methoxyestrone 3-glucuronide2-hydroxy-estradiol-2-glucuronideSULT1E1UGT1A1Estradiol sulfateQ9TU62_PANTRSULT1A1EstradiolQ9N256_PANTRCYP1A1UGT1A1Estradiol-3-glucuronideEstrone-2,3-quinone2-Methoxyestradiol-3-glucuronide2-Hydroxyestrone-3-glucuronideSuperoxideQ9TU62_PANTRNQO1Q9TU62_PANTR2-HydroxyestradiolUGT1A1UGT1A3SuperoxideOxygen4-hydroxyestroneUGT2B7Q9TU62_PANTRGSTM1SULT1A1B1NL93_PANTREstradiol-2,3-semiquinoneEstradiol-3,4-quinoneARSEARSD4-hydroxy-estradiol-4-glucuronideEstrone-3,4-quinoneQ9TU62_PANTR16a-HydroxyestroneEstrone-17-glucuronideCOMT


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP697(r30275) with a 77% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Raftogianis R, Creveling C, Weinshilboum R, Weisz J; ''Estrogen metabolism by conjugation.''; J Natl Cancer Inst Monogr, 2000 PubMed Europe PMC Scholia
  2. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL; ''Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.''; Breast Cancer Res, 2005 PubMed Europe PMC Scholia
  3. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG; ''Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.''; Proc Natl Acad Sci U S A, 1997 PubMed Europe PMC Scholia
  4. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL; ''Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.''; Carcinogenesis, 2003 PubMed Europe PMC Scholia
  5. Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL; ''Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.''; Chem Biol Interact, 2004 PubMed Europe PMC Scholia
  6. Guillemette C, Belanger A, Lepine J; ''Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.''; Breast Cancer Res, 2004 PubMed Europe PMC Scholia
  7. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM; ''Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  8. Lakhani NJ, Sarkar MA, Venitz J, Figg WD; ''2-Methoxyestradiol, a promising anticancer agent.''; Pharmacotherapy, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106940view13:40, 17 September 2019MaintBotHMDB identifier normalization
88027view13:33, 25 July 2016SusanOntology Term : 'steroid metabolic pathway' added !
77609view08:05, 30 September 2014Mkutmonconnected lines
74172view14:55, 2 April 2014EgonwUpdated the PubChem-compound data source.
69275view18:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
58912view04:48, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41584view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
34312view22:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33586view09:51, 1 December 2009MaintBotRemoved group label
30504view21:43, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
16a-HydroxyestroneMetaboliteHMDB00335 (HMDB)
2-HydroxyestradiolMetaboliteHMDB00338 (HMDB)
2-Hydroxyestrone-3-glucuronideMetabolite
2-HydroxyestroneMetaboliteHMDB00343 (HMDB)
2-Methoxyestradiol-3-glucuronideMetabolite
2-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
2-Methoxyestrone 3-glucuronideMetaboliteHMDB04482 (HMDB)
2-MethoxyestroneMetaboliteHMDB00010 (HMDB)
2-hydroxy-estradiol-2-glucuronideMetabolite
2-hydroxy-estradiol-sulfateMetabolite
2-hydroxyestradiol-3-glucuronideMetabolite
4-Hydroxyestradiol-3-glucuronideMetabolite
4-Methoxyestradiol-3-glucuronideMetabolite
4-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
4-MethoxyestroneMetabolite
4-Methoxyestrone-3-glucuronideMetabolite
4-hydroxy-estradiol-4-glucuronideMetabolite
4-hydroxy-estradiol-sulfateMetabolite
4-hydroxyestradiolMetabolite
4-hydroxyestroneMetabolite
4-hydroxyestrone-3-glucuronideMetabolite
ARSDGeneProduct
ARSEGeneProductENSPTRG00000021629 (Ensembl)
B1NL93_PANTRGeneProductENSPTRG00000019460 (Ensembl)
COMTGeneProductENSPTRG00000014070 (Ensembl)
CYP1A1GeneProductENSPTRG00000007280 (Ensembl)
CYP1B1GeneProductENSPTRG00000011843 (Ensembl)
EstradiolMetabolite
Estradiol sulfateMetabolite
Estradiol-17-glucuronideMetabolite
Estradiol-2,3-quinoneMetabolite
Estradiol-2,3-semiquinoneMetabolite
Estradiol-3,4-quinoneMetabolite
Estradiol-3,4-semiquinoneMetabolite
Estradiol-3-glucuronideMetaboliteHMDB06224 (HMDB)
Estrone sulfateMetaboliteHMDB01425 (HMDB)
Estrone-17-glucuronideMetaboliteHMDB04483 (HMDB)
Estrone-2,3-quinoneMetabolite148381 (PubChem)
Estrone-2,3-semiquinoneMetabolite
Estrone-3,4-quinoneMetabolite114862 (PubChem)
Estrone-3,4-semiquinoneMetabolite
Estrone-3-glucuronideMetaboliteHMDB04483 (HMDB)
EstroneMetaboliteHMDB00145 (HMDB)
GSTA1GeneProductENSPTRG00000032454 (Ensembl)
GSTM1GeneProductENSPTRG00000001061 (Ensembl)
NQO1GeneProductENSPTRG00000008284 (Ensembl)
OxygenMetaboliteHMDB01377 (HMDB)
Q9N256_PANTRGeneProductENSPTRG00000007281 (Ensembl)
Q9TU62_PANTRGeneProductENSPTRG00000013058 (Ensembl)
STSGeneProduct465478 (Entrez Gene)
SULT1A1GeneProductENSPTRG00000022685 (Ensembl)
SULT1E1GeneProductENSPTRG00000016118 (Ensembl)
SuperoxideMetaboliteHMDB02168 (HMDB)
UGT1A1GeneProduct449596 (Entrez Gene)
UGT1A3GeneProduct
UGT1A9GeneProduct741990 (Entrez Gene)
UGT2B7GeneProductENSPTRG00000031178 (Ensembl)

Annotated Interactions

No annotated interactions
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