DNA replication (Saccharomyces cerevisiae)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none OriginOrc3Orc2Orc5Orc2Orc3Orc5Orc4Orc1Orc3Orc5Orc4Orc2Cdc6Cdc6Cdt1Cdt1GemininCdc6Cdt1Mcm10Cdt1Phosphorylation of Mcm 2-7 complexDNA polymerase alpha: primase: origin complexDNA polymerase alpha: primase: origin complexCTPUTPRNA PrimerdUTPPhosphorylated Orc1UbiquitinPhosphorylated Cdc6Ubiquitinated Orc1Ubiquitinated Cdc6Degraded by proteasome in cytosolDegraded by proteasome in cytosolRNA primer-DNA primerRNA primer-DNA primerp49p58p70p180RFC36RFC37RFC38RFC40RFC140Mcm 4,6,7 trimer forms and associatesUbiquitinwith the replication forkOrc2Orc3RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerRFC Heteropentamer:RNA primer-DNA primer:RNA primer-DNA primer:origin duplex:PCNAPrimaseDNA PolymeraseaPre-replicative complex2. Activation of the pre-replicative complex3. DNA replication initiationPre-replicative complex1. Assembly of the pre-replicative complexMcm2Mcm3Mcm4Mcm6Mcm7Orc ComplexCdc6Cdt1Mcm2Mcm3Mcm4Mcm6Mcm74. Switching of origins to post-replicative state5. Leading/lagging strand synthesisOrc complexProcessive complexOrc complexOrc complexOrc complexMcm5Mcm5HOMOLOGY MAPPRFA2RPA3RPA4POL1PRI1PRI2DPB2POL2ORC3LORC2ORC5LORC4LORC1LORC6LGMNNCDT1RPL40AMCM6CDC46CDC54MCM3MCM2CDC47MCM10CDK2POL12RFC3RFC2RFC5RFC4RFC1POL30ASKCDC7RFA1CDC45HYS2POLD3POLD4CDC2CDC6UBI4GTPATPdCTPdGTPdATPATPADPATPADPATPName: DNA ReplicationOrganism: Saccharomyces cerevisiae


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Image:Featured.pngReview changes for Featured
Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : transport pathway
 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  3. Marahrens Y, Stillman B; ''A yeast chromosomal origin of DNA replication defined by multiple functional elements.''; Science, 1992 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139038
Featured
Approved
view19:29, 12 May 2025Khanspersupdated fint size and connected unconnected interactions
139035view19:22, 12 May 2025KhanspersModified description
139034view19:20, 12 May 2025KhanspersModified description
117289view10:58, 20 May 2021EweitzModified title
102295view19:29, 17 December 2018KhanspersModified description
78398view10:25, 7 January 2015MaintBotadded missing graphIds
76275view21:24, 25 June 2014KhanspersModified description
76274view21:24, 25 June 2014Khanspersremoved genmapp comments
76273view21:22, 25 June 2014Khanspersoverhaul
71354view18:03, 17 October 2013MaintBotAutomated update of data sources
69761view11:05, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69672view20:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67159view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41916view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
35199view15:38, 11 February 2010ThomasModified description
35198view15:38, 11 February 2010ThomasModified description
35197view15:37, 11 February 2010Thomasadded literature
34367view22:36, 9 December 2009MaintBotAutomatic update of empty xrefs
20699view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:DNA replication Reactome]] moved to [[Pathway:WP13]]: Moved to stable identifier
12692view07:58, 17 May 2008MaintBotautomated metabolite conversion
8540view14:02, 7 January 2008MaintBotAdded to category $category
19420view14:02, 7 January 2008D.KorenUploaded new pathway
8538view14:02, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ADP58-64-0 (CAS)
ASKGeneProduct
ATP1927-31-7 (CAS)
CDC2GeneProduct851456 (Entrez Gene)
CDC45GeneProduct850793 (Entrez Gene)
CDC46GeneProduct850980 (Entrez Gene)
CDC47GeneProduct852501 (Entrez Gene)
CDC54GeneProduct856130 (Entrez Gene)
CDC6GeneProduct853244 (Entrez Gene)
CDC7GeneProduct851545 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct
DPB2GeneProduct856305 (Entrez Gene)
GMNNGeneProduct
GTP2564-35-4 (CAS)
HYS2GeneProduct853462 (Entrez Gene)
MCM10GeneProduct854656 (Entrez Gene)
MCM2GeneProduct852258 (Entrez Gene)
MCM3GeneProduct856680 (Entrez Gene)
MCM6GeneProduct852673 (Entrez Gene)
ORC1LGeneProduct
ORC2GeneProduct852352 (Entrez Gene)
ORC3LGeneProduct
ORC4LGeneProduct
ORC5LGeneProduct
ORC6LGeneProduct
POL12GeneProduct852245 (Entrez Gene)
POL1GeneProduct855621 (Entrez Gene)
POL2GeneProduct855459 (Entrez Gene)
POL30GeneProduct852385 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
PRI1GeneProduct854825 (Entrez Gene)
PRI2GeneProduct853821 (Entrez Gene)
RFA1GeneProduct851266 (Entrez Gene)
RFA2GeneProduct855404 (Entrez Gene)
RFC1GeneProduct854392 (Entrez Gene)
RFC2GeneProduct853531 (Entrez Gene)
RFC3GeneProduct855426 (Entrez Gene)
RFC4GeneProduct854059 (Entrez Gene)
RFC5GeneProduct852383 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RPL40AGeneProduct854658 (Entrez Gene)
UBI4GeneProduct850620 (Entrez Gene)
dATP1927-31-7 (CAS)
dCTP2056-98-6 (CAS)
dGTP2564-35-4 (CAS)

Annotated Interactions

No annotated interactions
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