Nod-like receptor (NLR) signaling pathway (Danio rerio)

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1-4, 6, 76p10transcriptionCARDNACHTCaspase-1p10IκBαCARDdegradationPYDASCp20TAB1RIP2K63-linked UbCARDNod1NACHTNACHTPYDCARDPYDp20IL-1� and IL-18KDNALP3NACHTPYDNod2NACHTPYDInflammasome pathwayTAB2zgc:152984p50zgc:172209RelAchukMDPikbkbTriDAPCARDCARDCARDCARDLOC562176ikbkgMAPKDAMPSmap3k7


Description

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP288(r28883) with a 50% conversion rate.

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Bibliography

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  1. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE; ''Nod-like proteins in immunity, inflammation and disease.''; Nat Immunol, 2006 PubMed Europe PMC Scholia
  2. Meylan E, Tschopp J, Karin M; ''Intracellular pattern recognition receptors in the host response.''; Nature, 2006 PubMed Europe PMC Scholia
  3. Shaw MH, Reimer T, Kim YG, Nu�ez G; ''NOD-like receptors (NLRs): bona fide intracellular microbial sensors.''; Curr Opin Immunol, 2008 PubMed Europe PMC Scholia
  4. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH; ''Nod-like proteins in inflammation and disease.''; J Pathol, 2008 PubMed Europe PMC Scholia
  5. kufer t;
  6. Mariathasan S, Monack DM; ''Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.''; Nat Rev Immunol, 2007 PubMed Europe PMC Scholia
  7. Kufer TA; ''Signal transduction pathways used by NLR-type innate immune receptors.''; Mol Biosyst, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116894view11:22, 15 May 2021EweitzModified title
87916view12:59, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
87914view12:59, 25 July 2016ElisaOntology Term : 'signaling pathway pertinent to immunity' added !
71975view00:25, 24 October 2013MaintBotremoved data source from nodes without identifier
70186view01:56, 13 July 2013AlexanderPicoModified title
69947view20:35, 11 July 2013MaintBotModified description
69923view19:49, 11 July 2013MaintBotupdating to 2013 schema
40789view22:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
34179view21:21, 9 December 2009MaintBotAutomatic update of empty xrefs
32333view13:29, 15 August 2009MaintBotFixed text labels
31943view12:58, 14 August 2009MaintBotFixed group labels
31375view20:38, 13 August 2009MaintBotFixed text labels
31071view01:29, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CARDGeneProduct
DAMPSMetabolite
LOC562176GeneProduct562176 (Entrez Gene)
MAPKGeneProduct
MDPMetabolite
RelAGeneProduct415099 (Entrez Gene)
TriDAPMetabolite
chukGeneProduct393287 (Entrez Gene)
ikbkbGeneProduct563560 (Entrez Gene)
ikbkgGeneProduct541530 (Entrez Gene)
map3k7GeneProduct553788 (Entrez Gene)
p50GeneProduct
zgc:152984GeneProduct566811 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)

Annotated Interactions

No annotated interactions
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