Nod-like receptor (NLR) signaling (Homo sapiens)

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1, 2, 4-77CARDK63-linked UbCARDtranscriptionNALP3p10TAB2PYDIκBαCaspase-1NACHTIL-1� and IL-18CARDKDNod1TAB1PYDNACHTNACHTInflammasome pathwayPYDCARDPYDp20p10Nod2p20degradationNACHTNACHTPYDASCRIP2IKKbetaERKIKKalphaJNKRelAERBB2IPNEMOCARDCARDMDPp50DAMPSCARDMAPKTAK1CARDTriDAP


Description

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.

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Bibliography

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  1. Mariathasan S, Monack DM; ''Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.''; Nat Rev Immunol, 2007 PubMed Europe PMC Scholia
  2. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH; ''Nod-like proteins in inflammation and disease.''; J Pathol, 2008 PubMed Europe PMC Scholia
  3. Kufer TA; ''Signal transduction pathways used by NLR-type innate immune receptors.''; Mol Biosyst, 2008 PubMed Europe PMC Scholia
  4. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE; ''Nod-like proteins in immunity, inflammation and disease.''; Nat Immunol, 2006 PubMed Europe PMC Scholia
  5. Shaw MH, Reimer T, Kim YG, Nu�ez G; ''NOD-like receptors (NLRs): bona fide intracellular microbial sensors.''; Curr Opin Immunol, 2008 PubMed Europe PMC Scholia
  6. Meylan E, Tschopp J, Karin M; ''Intracellular pattern recognition receptors in the host response.''; Nature, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129691view00:49, 22 May 2024EweitzModified title
125016view18:26, 13 January 2023EgonwNot clear what that ID was and there are many MAPKs in NCBI Gene and HGNC alike
118398view14:10, 27 May 2021Mkutmonremoved unused reference
116892view11:20, 15 May 2021EweitzModified title
80026view22:02, 30 April 2015Zaricorrected ID for RelA
70187view01:56, 13 July 2013AlexanderPicoModified title
69921view19:47, 11 July 2013MaintBotupdating to 2013 schema
67511view11:19, 26 June 2013DdiglesOntology Term : 'NOD-like receptor signaling pathway' added !
46086view02:22, 15 December 2011AllanKuchinskyupdated HGNC IDs
45354view20:39, 7 October 2011KhanspersOntology Term : 'NLR signaling pathway' added !
45353view20:38, 7 October 2011KhanspersModified description
41195view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
32385view16:57, 15 August 2009MaintBotFixed text labels
32028view13:25, 14 August 2009MaintBotFixed group labels
28883view09:41, 10 March 2009Thomasannotated some gene boxes and linked lines
27722view16:25, 14 January 2009Andi1006140109
27720view16:22, 14 January 2009Andi1006140109
27718view16:21, 14 January 2009Andi1006140109
27714view16:17, 14 January 2009Andi1006140109
27712view16:14, 14 January 2009Andi1006Periodical save, work in progress
27706view15:44, 14 January 2009Andi1006Periodical save, work in progress
27701view15:33, 14 January 2009Andi1006Periodical save, work in progress
27697view15:23, 14 January 2009Andi1006Periodical save, work in progress
27695view15:06, 14 January 2009Andi1006Periodical save, work in progress
27691view14:54, 14 January 2009Andi1006more detailed
27677view13:51, 14 January 2009Andi1006Periodical save, work in progress
27673view13:41, 14 January 2009Andi1006Periodical save, work in progress
27666view13:10, 14 January 2009Andi1006Periodical save, work in progress
27663view13:07, 14 January 2009Andi1006more detailed
27661view13:00, 14 January 2009Andi1006Periodical save, work in progress
27657view12:50, 14 January 2009Andi1006Periodical save, work in progress
27655view12:42, 14 January 2009Andi1006more detailed
21285view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:NLR proteins]] moved to [[Pathway:WP288]]: Moved to stable identifier
18694view11:50, 2 September 2008KuferSpecify description
18692view11:45, 2 September 2008KuferModified categories
18690view11:44, 2 September 2008KuferModified description
18688view11:43, 2 September 2008KuferModified description
18686view11:42, 2 September 2008KuferNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CARDGeneProduct
DAMPSMetabolite
ERBB2IPGeneProduct55914 (Entrez Gene)
ERKGeneProduct2048 (Entrez Gene)
IKKalphaGeneProduct1147 (Entrez Gene)
IKKbetaGeneProduct3551 (Entrez Gene)
JNKGeneProduct5599 (Entrez Gene)
MAPKGeneProductMAPK (HGNC)
MDPMetabolite
NEMOGeneProduct8517 (Entrez Gene)
RelAGeneProductRelA (HGNC)
TAK1GeneProduct6885 (Entrez Gene)
TriDAPMetabolite
p50GeneProduct958 (Entrez Gene)

Annotated Interactions

No annotated interactions

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