Nod-like receptor (NLR) signaling pathway (Gallus gallus)

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2-73p20degradationp10NACHTInflammasome pathwayp20transcriptionCARDNACHTPYDCaspase-1p10NACHTTAB2TAB1IκBαCARDKDPYDNACHTPYDCARDCARDIL-1� and IL-18NALP3RIP2ASCNACHTPYDNod1Nod2PYDK63-linked UbTriDAPNEMOCD40IKBKBDAMPSRelAMDPMAP3K7CARDEPHB2CARDERBB2IPCARDMAPKRCJMB04_19h23MAPK8CARD


Description

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP288(r28883) with a 50% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Shaw MH, Reimer T, Kim YG, Nu�ez G; ''NOD-like receptors (NLRs): bona fide intracellular microbial sensors.''; Curr Opin Immunol, 2008 PubMed Europe PMC Scholia
  2. Mariathasan S, Monack DM; ''Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.''; Nat Rev Immunol, 2007 PubMed Europe PMC Scholia
  3. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE; ''Nod-like proteins in immunity, inflammation and disease.''; Nat Immunol, 2006 PubMed Europe PMC Scholia
  4. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH; ''Nod-like proteins in inflammation and disease.''; J Pathol, 2008 PubMed Europe PMC Scholia
  5. Kufer TA; ''Signal transduction pathways used by NLR-type innate immune receptors.''; Mol Biosyst, 2008 PubMed Europe PMC Scholia
  6. Meylan E, Tschopp J, Karin M; ''Intracellular pattern recognition receptors in the host response.''; Nature, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
119598view14:11, 21 July 2021FinterlyRemoved PublicationXref b3c which contains no information
117032view14:03, 16 May 2021EweitzModified title
87920view12:59, 25 July 2016ElisaOntology Term : 'signaling pathway pertinent to immunity' added !
87917view12:59, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
74232view16:31, 8 April 2014EgonwRemoved a data source where no ID was given.
70188view01:57, 13 July 2013AlexanderPicoModified title
69948view20:36, 11 July 2013MaintBotModified description
69922view19:48, 11 July 2013MaintBotupdating to 2013 schema
40977view22:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
33476view15:06, 30 November 2009MaintBotRemoved group label
31526view21:42, 13 August 2009MaintBotFixed text labels
30368view20:57, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CARDGeneProduct
CD40GeneProduct395385 (Entrez Gene)
DAMPSMetabolite
EPHB2GeneProduct396513 (Entrez Gene)
ERBB2IPGeneProduct431583 (Entrez Gene)
IKBKBGeneProduct426792 (Entrez Gene)
MAP3K7GeneProduct421808 (Entrez Gene)
MAPK8GeneProduct423778 (Entrez Gene)
MAPKGeneProduct
MDPMetabolite
NEMOGeneProduct
RCJMB04_19h23GeneProduct423669 (Entrez Gene)
RelAGeneProduct
TriDAPMetabolite

Annotated Interactions

No annotated interactions
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