Nod-like receptor (NLR) signaling pathway (Pan troglodytes)

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2-76CARDIκBαCARDdegradationASCp20K63-linked UbPYDtranscriptionInflammasome pathwayPYDNALP3p10RIP2KDTAB2CARDNod2NACHTPYDCARDPYDp10p20Nod1IL-1� and IL-18NACHTNACHTNACHTNACHTPYDCaspase-1TAB1CARDRelAMAPKIKBKBMAP3K7IKBKGp50TriDAPCHUKERBB2IPCARDDAMPSCARDCARDMAPK8EPHB2MDP


Description

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP288(r28883) with a 50% conversion rate.

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Bibliography

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  1. kufer t;
  2. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE; ''Nod-like proteins in immunity, inflammation and disease.''; Nat Immunol, 2006 PubMed Europe PMC Scholia
  3. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH; ''Nod-like proteins in inflammation and disease.''; J Pathol, 2008 PubMed Europe PMC Scholia
  4. Meylan E, Tschopp J, Karin M; ''Intracellular pattern recognition receptors in the host response.''; Nature, 2006 PubMed Europe PMC Scholia
  5. Shaw MH, Reimer T, Kim YG, Nu�ez G; ''NOD-like receptors (NLRs): bona fide intracellular microbial sensors.''; Curr Opin Immunol, 2008 PubMed Europe PMC Scholia
  6. Mariathasan S, Monack DM; ''Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.''; Nat Rev Immunol, 2007 PubMed Europe PMC Scholia
  7. Kufer TA; ''Signal transduction pathways used by NLR-type innate immune receptors.''; Mol Biosyst, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117029view14:02, 16 May 2021EweitzModified title
87924view13:00, 25 July 2016ElisaOntology Term : 'signaling pathway pertinent to immunity' added !
87922view13:00, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
71959view23:28, 23 October 2013MaintBotremoved data source from nodes without identifier
70190view01:58, 13 July 2013AlexanderPicoModified title
69936view20:00, 11 July 2013MaintBotupdating to 2013 schema
69935view19:59, 11 July 2013MaintBotModified description
69933view19:59, 11 July 2013MaintBotModified description
41516view01:56, 2 March 2011MaintBotRemoved redundant pathway information and comments
34256view21:49, 9 December 2009MaintBotAutomatic update of empty xrefs
33571view09:47, 1 December 2009MaintBotRemoved group label
31598view22:07, 13 August 2009MaintBotFixed text labels
30483view21:36, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CARDGeneProduct
CHUKGeneProduct450673 (Entrez Gene)
DAMPSMetabolite
EPHB2GeneProduct456613 (Entrez Gene)
ERBB2IPGeneProduct471527 (Entrez Gene)
IKBKBGeneProduct472749 (Entrez Gene)
IKBKGGeneProduct743415 (Entrez Gene)
MAP3K7GeneProduct462888 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MAPKGeneProduct
MDPMetabolite
RelAGeneProduct466665 (Entrez Gene)
TriDAPMetabolite
p50GeneProduct

Annotated Interactions

No annotated interactions
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