Nod-like receptor (NLR) signaling pathway (Bos taurus)

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1-66p20degradationp10NACHTInflammasome pathwayp20transcriptionCARDNACHTPYDCaspase-1p10NACHTTAB2TAB1IκBαCARDKDPYDNACHTPYDCARDCARDIL-1� and IL-18NALP3RIP2ASCNACHTPYDNod1Nod2PYDK63-linked UbTriDAPIKBKGCD40IKBKBDAMPSRelAMDPMAP3K7CARDEPHB2CARDERBB2IPCARDMAPKCHUKMAPK8CARD


Description

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP288(r28883) with a 57% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE; ''Nod-like proteins in immunity, inflammation and disease.''; Nat Immunol, 2006 PubMed Europe PMC Scholia
  2. Mariathasan S, Monack DM; ''Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.''; Nat Rev Immunol, 2007 PubMed Europe PMC Scholia
  3. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH; ''Nod-like proteins in inflammation and disease.''; J Pathol, 2008 PubMed Europe PMC Scholia
  4. Meylan E, Tschopp J, Karin M; ''Intracellular pattern recognition receptors in the host response.''; Nature, 2006 PubMed Europe PMC Scholia
  5. Kufer TA; ''Signal transduction pathways used by NLR-type innate immune receptors.''; Mol Biosyst, 2008 PubMed Europe PMC Scholia
  6. Shaw MH, Reimer T, Kim YG, Nu�ez G; ''NOD-like receptors (NLRs): bona fide intracellular microbial sensors.''; Curr Opin Immunol, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134195view18:24, 16 July 2024EgonwRemoved an empty, unused reference
134191view18:20, 16 July 2024EgonwRemoved template comments
117028view14:02, 16 May 2021EweitzModified title
89539view11:22, 16 September 2016Mkutmonremove redundant ontology tag in GPML
80851view15:28, 30 June 2015Mkutmonhomology conversion
71852view20:13, 18 October 2013MaintBotremoved data source from nodes without identifier
70192view01:59, 13 July 2013AlexanderPicoModified title
69950view20:37, 11 July 2013MaintBotModified description
63476view17:21, 10 May 2013MaintBotupdating gpml
40508view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
33751view23:59, 8 December 2009MaintBotAutomatic update of empty xrefs
32505view12:50, 17 August 2009MaintBotFixed text labels
32195view12:36, 15 August 2009MaintBotFixed text labels
31671view11:42, 14 August 2009MaintBotFixed group labels
31203view19:34, 13 August 2009MaintBotFixed text labels
30601view22:15, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CARDGeneProduct
CD40GeneProduct286849 (Entrez Gene)
CHUKGeneProduct281073 (Entrez Gene)
DAMPSMetabolite
EPHB2GeneProduct535137 (Entrez Gene)
ERBB2IPGeneProduct512866 (Entrez Gene)
IKBKBGeneProduct281854 (Entrez Gene)
IKBKGGeneProduct281855 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPKGeneProduct
MDPMetabolite
RelAGeneProduct508233 (Entrez Gene)
TriDAPMetabolite

Annotated Interactions

No annotated interactions
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