Retinoblastoma gene in cancer (Homo sapiens)

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321SUV39H1MCM6cell cycle checkpointPCNARBBP4RRM2CKS1BTFAMCDK1CDK1DNA damage response, signal transduction resulting in induction of apoptosisCCND3RPA1TFDP1TLX2RFC3CDC25BSMC3HMGB1ANLNCDKN1BRFC4CDC25AMASP1RABIFCCDC6JNK cascadeDHFRMDM2TYMSCCNE1ORC1POLECCNA2DNMT1PRIM1CDK2WEE1RFC5MCM7GTPBP1RBP1histone H3-K9 methylationregulation of cyclin-dependent protein kinase activityCDC7PRKDCRAF1JUNCBX5SMC2CDK1G1/S transition of mitotic cell cycleCCNE2CCNB1RB1CCNA1BRCA1LY6EDNA replicationM/G1 transition of mitotic cell cycleCHEK1MCM7MAPK13STMN1RPA2CDT1RPA3H2AFZMDM2ABL1MYCSMARCA2POLA1PLK4TTKDNA replication checkpointGeneProductBARD1CCNB2FANCGKIF4AE2F1HMGB2positive regulation of transcription involved in G1/S phase of mitotic cell cycleG2/M transition of mitotic cell cycleCCNE1RPA1ABL1mitotic cell cycleHLTFTOP2ACDC45CCNE1RRM1TFDP2MSH6POLE2MCM3FAF1POLD3PRMT2CCNA2G1/S transition of mitotic cell cycleHDAC1CDK1CDKN1ASP1RAF1PathwaySKP2NPATDCKE2F1TP53MCM4CCND1CDKN1BSMC1ARB1RB1TFDP1E2F1RB1SKP2RB1TFDP1E2F1TFDP1E2F2TFDP1E2F3RB1RB1ZNF655RB1RB1MDM2TFDP1E2F1MDM2RBP1HDAC1TFDP1E2F1RB1RB1TFDP1E2F1RB1RB1RB1RB1SP1RB1RB1JUNTP53E2F1E2F3E2F2SKP2E2F3TFDP1G1/S transition of mitotic cell cycleG1/S transition of mitotic cell cycleHDAC1TFDP1E2F1TFDP1E2F1Rb-E2F complexTFDP1E2F2TFDP1E2F3


Description

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Bibliography

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  1. Welch PJ, Wang JY; ''A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.''; Cell, 1993 PubMed Europe PMC Scholia
  2. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  3. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC Scholia
  4. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L; ''An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  5. Welch PJ, Wang JY; ''Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.''; Mol Cell Biol, 1995 PubMed Europe PMC Scholia
  6. Domínguez R, Famulari A, Vila J; ''[Leukoencephalopathy: the frontier between what is reversible and what is persistent].''; Rev Neurol, 1997 PubMed Europe PMC Scholia
  7. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116593view16:31, 8 May 2021EweitzModified title
113796view11:10, 24 November 2020Finterlysmall graphical update
108145view10:34, 29 November 2019FehrhartOntology Term : 'cancer' added !
108144view10:34, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106493view21:43, 4 September 2019KhanspersModified description
105447view04:57, 8 August 2019KhanspersModified description
102997view14:43, 31 January 2019Mkutmonupdated outdated ensembl ids
98748view01:20, 4 October 2018AlexanderPicoModified title
98747view01:20, 4 October 2018AlexanderPicoModified title
98354view05:35, 24 August 2018EgonwUpdated the MIR21 identifier.
87639view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
84651view22:24, 10 March 2016KhanspersQuick edit to datanode annotation or property
80443view05:49, 23 June 2015KhanspersAdded mir29b targeting of CDK6
80434view20:26, 22 June 2015KhanspersAdded mir21 targeting of MSH6
80433view20:17, 22 June 2015KhanspersAdded mir21 targetinf of E2F1
80430view20:00, 22 June 2015KhanspersAdded mir21 targeting of CDC25A
80174view11:06, 16 May 2015EveloModified title
80173view11:01, 16 May 2015EveloModified description
80172view10:44, 16 May 2015EveloModified description
80171view10:40, 16 May 2015EveloModified description
78573view14:50, 7 January 2015MaintBotadded missing graphIds
76353view18:32, 3 July 2014EgonwRemoved database names when no identifier was given.
76335view22:48, 2 July 2014MaintBotchanged pathway node Xrefs
72248view22:23, 29 October 2013MaintBotchanged xrefs from Gene Ontology to WikiPathways
71096view14:30, 4 October 2013Mkutmonconnected lines
70977view04:49, 19 September 2013JYoungrenSpecify description
70976view04:40, 19 September 2013JYoungrenPeriodical save, work in progress
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70934view23:18, 15 September 2013JYoungrenSpecify description
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ANLNGeneProduct54443 (Entrez Gene)
BARD1GeneProduct580 (Entrez Gene)
BRCA1GeneProduct672 (Entrez Gene)
CBX5GeneProduct23468 (Entrez Gene)
CCDC6GeneProduct8030 (Entrez Gene)
CCNA1GeneProduct8900 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCNB2GeneProduct9133 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDC45GeneProduct8318 (Entrez Gene)
CDC7GeneProduct8317 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDT1GeneProduct81620 (Entrez Gene)
CHEK1GeneProduct1111 (Entrez Gene)
CKS1BGeneProduct1163 (Entrez Gene)
DCKGeneProduct1633 (Entrez Gene)
DHFRGeneProduct1719 (Entrez Gene)
DNA damage response, signal transduction resulting in induction of apoptosisPathwayGO:0008630 (GeneOntology)
DNA replication checkpointPathwayGO:0000076 (GeneOntology)
DNA replicationPathwayGO:0006260 (GeneOntology)
DNMT1GeneProduct1786 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1869 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
FAF1GeneProduct11124 (Entrez Gene)
FANCGGeneProduct2189 (Entrez Gene)
G1/S transition of mitotic cell cyclePathwayGO:0000082 (GeneOntology)
G2/M transition of mitotic cell cyclePathwayGO:0000086 (GeneOntology)
GTPBP1GeneProduct9567 (Entrez Gene)
GeneProductGeneProduct
H2AFZGeneProduct3015 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
HLTFGeneProduct6596 (Entrez Gene)
HMGB1GeneProduct3146 (Entrez Gene)
HMGB2GeneProduct3148 (Entrez Gene)
JNK cascadePathwayGO:0007254 (GeneOntology)
JUNGeneProduct3725 (Entrez Gene)
KIF4AGeneProduct24137 (Entrez Gene)
LY6EGeneProduct4061 (Entrez Gene)
M/G1 transition of mitotic cell cyclePathwayGO:0000216 (GeneOntology)
MAPK13GeneProduct5603 (Entrez Gene)
MASP1GeneProduct5648 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MSH6GeneProduct2956 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NPATGeneProduct4863 (Entrez Gene)
ORC1GeneProduct4998 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
PLK4GeneProduct10733 (Entrez Gene)
POLA1GeneProduct5422 (Entrez Gene)
POLD3GeneProduct10714 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRKDCGeneProduct5591 (Entrez Gene)
PRMT2GeneProduct3275 (Entrez Gene)
PathwayPathway
RABIFGeneProduct5877 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RBBP4GeneProduct5928 (Entrez Gene)
RBP1GeneProduct5947 (Entrez Gene)
RFC3GeneProduct5983 (Entrez Gene)
RFC4GeneProduct5984 (Entrez Gene)
RFC5GeneProduct5985 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2Protein6118 (Entrez Gene)
RPA3Protein6119 (Entrez Gene)
RRM1GeneProduct6240 (Entrez Gene)
RRM2GeneProduct6241 (Entrez Gene)
Rb-E2F complexPathwayGO:0035189 (GeneOntology)
SKP2GeneProduct6502 (Entrez Gene)
SMARCA2GeneProduct6595 (Entrez Gene)
SMC1AGeneProduct8243 (Entrez Gene)
SMC2GeneProduct10592 (Entrez Gene)
SMC3GeneProduct9126 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
SUV39H1GeneProduct6839 (Entrez Gene)
TFAMGeneProduct7019 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TLX2GeneProduct3196 (Entrez Gene)
TOP2AGeneProduct7153 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TTKGeneProduct7272 (Entrez Gene)
TYMSGeneProduct7298 (Entrez Gene)
WEE1GeneProduct7465 (Entrez Gene)
ZNF655Protein79027 (Entrez Gene)
cell cycle checkpointPathwayGO:0000075 (GeneOntology)
histone H3-K9 methylationPathwayGO:0051567 (GeneOntology)
mitotic cell cyclePathwayGO:0000278 (GeneOntology)
positive regulation of transcription involved in G1/S phase of mitotic cell cyclePathwayGO:0071931 (GeneOntology)
regulation of cyclin-dependent protein kinase activityPathwayGO:0000079 (GeneOntology)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2446"
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